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ASPH

Anti-ASPH Products
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: IF, FACS, FuncS
- Recombinant Anti-human ASPH Antibody (MOB-78)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC, FuncS
- Recombinant Anti-human ASPH Antibody Fab Fragment (MOB-78-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, Nert, FuncS
- Recombinant Anti-human ASPH Antibody scFv Fragment (MOB-78-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, Neut, FuncS
- Recombinant Human Anti-human ASPH Antibody Fab Fragment (MHH-78-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, IHC, FuncS
- Recombinant Human Anti-human ASPH Antibody scFv Fragment (MHH-78-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FC, FuncS
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IF, FC
- Anti-ASPH Immunohistochemistry Kit (VS-0325-XY189)
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- Species Reactivity: Human, Mouse, Rat
- Target: ASPH
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Muller glia cells)
Immune cell specificity
Immune cell enhanced (plasmacytoid DC)
Cell line specificity
Cell line enhanced (U-87 MG)
Interaction
Monomer (By similarity). Isoform 8 interacts with ORAI1 and STIM1. Isoform 4 interacts with CASQ2.
Molecular function
Dioxygenase, Oxidoreductase
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