Recombinant Anti-human CCR5 Intrabody [Tat] (CAT#: IAB-B039(T))
Recombinant anti-CCR5 intrabody in fusion with HIV Tat works within cells and is directed against human CCR5, expressed in 293T cells. CCR5-intrabody efficiently blocked surface expression of human CCR5 and thus prevented cellular interactions with CCR5-dependent HIV-1 and simian immunodeficiency virus envelope glycoprotein.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
Figure 1 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
Specifications
- Immunogen
- human chemokine (C-C motif) receptor 5 (gene/pseudogene)
- Host Species
- rabbit
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Antibody assay: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies
Product Property
- Purity
- Purity>95% by SDS-PAGE
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
- Alternative Names
- CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A
- Gene ID
- 1234
- UniProt ID
- P51681
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CCR5"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-078 | Recombinant Anti-mouse Ccr5 VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B039(A) | Recombinant Anti-human CCR5 Intrabody [(D-Arg)9] | PCA, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B039(G) | Recombinant Anti-human CCR5 Intrabody [+36 GFP] | FACS, ELISA, IF, FuncS | scFv-(+36GFP) |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-10000S | Anti-Human CCR5 Recombinant Antibody | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG4 |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-345 | Mouse Anti-CCR5 Recombinant Antibody (clone RoAb13) | Block, ELISA, FC | Mouse IgG |
| HPAB-0131CQ | Mouse Anti-CCR5 Recombinant Antibody (HPAB-0131CQ) | ELISA, FC | Mouse IgG |
| HPAB-0695-YJ | Rabbit Anti-CCR5 Recombinant Antibody (ST6) | ELISA, Block | Rabbit IgG |
| HPAB-0696-YJ | Human Anti-CCR5 Recombinant Antibody (ST6/34) | ELISA, Block | Humanized IgG |
| HPAB-1578WJ | Mouse Anti-CCR5 Recombinant Antibody (clone ST6/34) | ELISA, WB | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-345 | Mouse Anti-CCR5 Recombinant Antibody (clone RoAb13); Fab Fragment | Block, ELISA, FC | Mouse Fab |
| PFBC-446 | Mouse Anti-CCR5 Recombinant Antibody (clone 4B08); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1659-FY-S(P) | Human Anti-CCR5 Recombinant Antibody; scFv Fragment (HPAB-1659-FY-S(P)) | ELISA | Human scFv |
| HPAB-0695-YJ-F(E) | Rabbit Anti-CCR5 Recombinant Antibody (ST6); Fab Fragment | ELISA, Block | Rabbit Fab |
| HPAB-0696-YJ-F(E) | Human Anti-CCR5 Recombinant Antibody (ST6/34); Fab Fragment | ELISA, Block | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1531CL | Human Anti-CCR5 Recombinant Antibody (TAB-1531CL) | FuncS | Human IgG4 |
| TAB-1531CL-F(E) | Human Anti-CCR5 Recombinant Antibody; Fab Fragment (TAB-1531CL-F(E)) | FuncS | Human Fab |
| TAB-1532CL-F(E) | Human Anti-CCR5 Recombinant Antibody; Fab Fragment (TAB-1532CL-F(E)) | FuncS | Human Fab |
| TAB-1533CL-F(E) | Anti-Human CCR5 Recombinant Antibody Fab Fragment (15.186.35) | ELISA, WB | Human antibody |
| TAB-1534CL-F(E) | Anti-Human CCR5 Recombinant Antibody Fab Fragment (15.150.11) | ELISA, WB | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1535CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1535CL-S(P)) | ELISA, FC | Mouse scFv |
| TAB-1536CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1536CL-S(P)) | ELISA | Mouse scFv |
| TAB-1537CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1537CL-S(P)) | ELISA | Mouse scFv |
| TAB-1538CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1538CL-S(P)) | ELISA | Mouse scFv |
| TAB-1539CL-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (TAB-1539CL-S(P)) | ELISA | Mouse scFv |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-106LC | Recombinant Anti-Human CCR5 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-267CQ | Mouse Anti-CCR5 Recombinant Antibody (clone 45523.111) | FC, IHC-P, Neut | Mouse IgG2b |
| NEUT-268CQ | Mouse Anti-CCR5 Recombinant Antibody (clone CBL472) | FC, CyTOF, ICC, Neut | Mouse IgG2b |
| NEUT-269CQ | Mouse Anti-CCR5 Recombinant Antibody (clone MM0681-7D32) | FC, IHC-P, Neut | Mouse IgG2 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0047-YC-S(P) | Human Anti-CCR5 Recombinant Antibody (clone huPR0140); scFv Fragment | Block | Humanized scFv |
| HPAB-0131CQ-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (HPAB-0131CQ-S(P)) | ELISA, FC | Mouse scFv |
| PSBC-446 | Mouse Anti-CCR5 Recombinant Antibody (clone 4B08); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1038-FY-F(E) | Human Anti-CCR5 Recombinant Antibody (clone 36F11); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-1578WJ-S(P) | Mouse Anti-CCR5 Recombinant Antibody; scFv Fragment (clone ST6/34) | ELISA, WB | Mouse scFv |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-017CN | Mouse Anti-CCR5 Recombinant Antibody (clone PA14) | ELISA, WB, FC | Mouse IgG1 |
| NS-017CN-F(E) | Mouse Anti-CCR5 Recombinant Antibody (clone PA14); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| NS-017CN-S(P) | Mouse Anti-CCR5 Recombinant Antibody (clone PA14); scFv Fragment | ELISA, WB, FC | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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