Recombinant Anti-human CCR5 Intrabody [Tat]

Name: Recombinant Anti-human CCR5 Intrabody [Tat]
SKU: IAB-B039(T)
Rating: 5 (1 reviews)

CAT#: IAB-B039(T)

Recombinant anti-CCR5 intrabody in fusion with HIV Tat works within cells and is directed against human CCR5, expressed in 293T cells. CCR5-intrabody efficiently blocked surface expression of human CCR5 and thus prevented cellular interactions with CCR5-dependent HIV-1 and simian immunodeficiency virus envelope glycoprotein.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5

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Specifications

Immunogen
human chemokine (C-C motif) receptor 5 (gene/pseudogene)

Host Species
rabbit

Type
scFv-Tat

Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.

Species Reactivity
human

Applications
Antibody assay: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies

Product Property

Purity
Purity>95% by SDS-PAGE

Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Target

Alternative Names
CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A

Gene ID
1234

UniProt ID
P51681

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - IAB-B039(T).pdf

MSDS

MSDS - IAB-B039(T).pdf

COA

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