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    Recombinant Anti-human CCR5 Intrabody [Tat]

    CAT#: IAB-B039(T)

    Recombinant anti-CCR5 intrabody in fusion with HIV Tat works within cells and is directed against human CCR5, expressed in 293T cells. CCR5-intrabody efficiently blocked surface expression of human CCR5 and thus prevented cellular interactions with CCR5-dependent HIV-1 and simian immunodeficiency virus envelope glycoprotein.

    Gene Expression
    ❮
    Figure 1 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, U-266/84)
    ❯

    Specifications

    • Immunogen
    • human chemokine (C-C motif) receptor 5 (gene/pseudogene)
    • Host Species
    • rabbit
    • Type
    • scFv-Tat
    • Cell Penetrating Peptide
    • TAT
      TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
    • Species Reactivity
    • human
    • Applications
    • Antibody assay: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies

    Product Property

    • Purity
    • Purity>95% by SDS-PAGE
    • Storage
    • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

    Target

    • Alternative Names
    • CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A
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    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - IAB-B039(T).pdf

    MSDS

    MSDS - IAB-B039(T).pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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