Mouse Anti-CCR5 (clone MC-1) scFv-Fc Chimera (CAT#: VS-0425-FY15)

• Immunogen
• CHO cells expressing high levels of CCR5.

• Host Species
• Mouse

• Type
• Mouse IgG1, scFv-Fc

• Specificity
• It binds specifically to the first part of the second extracellular loop of human CCR5 and do not cross-react with CCR5 derived from rhesus macaques.

• Species Reactivity
• Human

• Clone
• MC-1

• Applications
• Flow Cytometry

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Flow Cytometry: 5 μg/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• C-C Motif Chemokine Receptor 5 (Gene/Pseudogene); Chemokine (C-C Motif) Receptor 5; HIV-1 Fusion Coreceptor; CC-CKR-5; ChemR13; CMKBR5; CCR-5; Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene); C-C Motif Chemokine Receptor 5 A159A; Chemokine Recptor CCR5 Delta32

• Gene ID
• 1234

• UniProt ID
• P51681

• Long Name
• C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Sulfated on at least 2 of the N-terminal tyrosines.
  Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
  O-glycosylated, but not N-glycosylated.
  Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated.
  Also sialylated glycans present which contribute to chemokine binding.
  Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
  Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
  Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
  Glycosylation at Ser6 and Ser7
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 2 sites

• Protein Refseq
• NP_000570.1; NP_001093638.1; NP_001381712.1

• Function
• Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
  May play a role in the control of granulocytic lineage proliferation or differentiation.
  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

• TAB-1540CL
• Anti-Human CCR5 Recombinant Antibody (MC-1)

• TAB-1540CL-S(P)
• Anti-Human CCR5 Recombinant Antibody scFv Fragment (MC-1)

• TAB-1540CL-F(E)
• Anti-Human CCR5 Recombinant Antibody Fab Fragment (MC-1)

Select a product category from the dropdown menu below to view related products.