Mouse Anti-CCR5 (clone MC-1) scFv-Fc Chimera
CAT#: VS-0425-FY15
This product features a single-chain variable fragment (scFv) antibody, fused to an Fc domain, designed for highly specific targeting of human CCR5. This antibody exhibits high specificity for the initial segment of the second extracellular loop of human CCR5, with no cross-reactivity observed against rhesus macaque CCR5.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
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Specifications
- Immunogen
- CHO cells expressing high levels of CCR5.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- It binds specifically to the first part of the second extracellular loop of human CCR5 and do not cross-react with CCR5 derived from rhesus macaques.
- Species Reactivity
- Human
- Clone
- MC-1
- Applications
- Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow Cytometry: 5 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- C-C Motif Chemokine Receptor 5 (Gene/Pseudogene); Chemokine (C-C Motif) Receptor 5; HIV-1 Fusion Coreceptor; CC-CKR-5; ChemR13; CMKBR5; CCR-5; Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene); C-C Motif Chemokine Receptor 5 A159A; Chemokine Recptor CCR5 Delta32
- Gene ID
- 1234
- UniProt ID
- P51681
- Long Name
- C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Sulfated on at least 2 of the N-terminal tyrosines.
Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
O-glycosylated, but not N-glycosylated.
Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated.
Also sialylated glycans present which contribute to chemokine binding.
Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
Glycosylation at Ser6 and Ser7
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- NP_000570.1; NP_001093638.1; NP_001381712.1
- Function
- Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
May play a role in the control of granulocytic lineage proliferation or differentiation.
Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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