Human Anti-CCR5 Recombinant Antibody (clone huPR0140)
CAT#: HPAB-0047-YC
The CC-chemokine receptor CCR5 is the major co-receptor for macrophage-tropic (R5) strains, and plays a crucial role in the sexual transmission of HIV-1 (4, 5, 21, 36). T cell line-tropic (X4) viruses use CXCR4 to enter target cells, and usually, but not always, emerge late in disease progression or as a consequence of virus propagation in tissue culture. Anti-CCR5 monoclonal antibodies have also shown the importance of the extracellular loops for viral entry
Published Data
Gene Expression
Figure 1 pro 140 serum concentrations following a single intrawennous injection in HIV-infected invidulas
Provides PRO 140 serum concentrations following a single intravenous injection in HIV-infected individuals,and shows differences between 0.5 mg/kg (rep resented by a square),2 mg/kg (represented by a triangle, and 5 mg/kg (represented by a diamond) amounts.
Figure 2 emax analysis of antiviral data generated with IV and SC PRO 140, measure as Logo change in HIV-1 RNA versus AUC, mg * day/mL
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
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Specifications
- Immunogen
- Immunized with L1.2-CCR5+ cells
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Human CCR5
- Species Reactivity
- Human
- Clone
- huPR0140
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene); HIV-1 Fusion Coreceptor; CC-CKR-5; ChemR13; CMKBR5; CCR-5; C-C Motif Chemokine Receptor 5 A159A; Chemokine (C-C Motif) Receptor 5; Chemokine Receptor CCR5; CD195 Antigen; C-C CKR-5; CCCKR5; IDDM22; CD195; CKR-5; CKR5
- Gene ID
- 1234
- UniProt ID
- P51681
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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