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CCR5

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Anti-CCR5 Recombinant Antibody Products

  • Anti-Human CCR5 Recombinant Antibody (TAB-10000S)
    • Derivation: Humanized (from mouse)
    • Species Reactivity: Human
    • Type: IgG4
    • Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele.
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