Anti-CD-138 (nBT062)-SPDB-DM4 ADC (BT-062/indatuximab ravtansine) (CAT#: ADC-L011)

• Antibody Overview
• chimeric anti-CD-138 monoclonal antibody, IgG4k

• Clone
• nBT062

• Antibody Conjugation
• Chimeric murine/human

• Linker
• SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)

• Linker Class/Description
• Class: Chemically cleavable Linker-Disulfide Linker
  Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

• Drug
• DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

• Introduction
• The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.

• Alternative Names
• SDC; CD138; SYND1; syndecan

• Gene ID
• 6382

• UniProt ID
• P18827

• ADC-015LCT
• Anti-CD138 (nBT062)-SPDB-DM4 ADC

• ADC-016LCT
• Anti-CD138 (nBT062)-SPP-DM1 ADC

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