Anti-Human CD14 Recombinant Antibody (18D11) (CAT#: TAB-1583CL)
This anti-CD 14 antibody can be used in research, diagnostic, and therapeutic applications.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FC
Figure 1 Functional characterization of anti-human CD14 Ab r18D11.
(A) Binding of increasing concentrations of r18D11 (△), raNIP (□), 18D11 F(ab)′2 (▲) or a control F(ab)′2 (■) to monocytes was determined by the ability of the Abs to displace 10 μg/ml of the original clone 18D11 mIgG1 from its CD14 binding site in human whole blood. Mean fluorescence intensity derived from a PE-conjugated anti-mouse IgG Ab was measured using flow cytometry. Fluorescence intensity in presence of original clone 18D11 alone was set to 100%. (B-D) Release of the proinflammatory cytokines IL-1β (B), TNF (C), and IL-6 (D) from human whole blood was induced with 100 ng/ml ultrapure LPS from E. coli O111:B4 in the presence of increasing concentrations of r18D11 (△) or the original clone 18D11 (▲). raNIP (□) and mIgG1 isotype control (■) (10 μg/ml) served as negative controls. (E) Monocyte oxidative burst was measured with flow cytometry after adding the different Ab preparations to human whole blood. Data are given as mean and SEM (n = 3 independent experiments). *p < 0.05 as compared with the negative PBS control.
Lau, C., Gunnarsen, K. S., Høydahl, L. S., Andersen, J. T., Berntzen, G., Pharo, A.,... & Nielsen, E. W. (2013). Chimeric anti-CD14 IGG2/4 hybrid antibodies for therapeutic intervention in pig and human models of inflammation. The Journal of Immunology, 191(9), 4769-4777.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 18D11
- Applications
- FC
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry.
Target
- Alternative Names
- CD14; CD14 molecule; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein
- Gene ID
- 929
- UniProt ID
- P08571
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1589CL | Anti-Human CD14 Recombinant Antibody (scFv2F9) | WB, FC, Block | Human antibody |
| TAB-1589CL-S(P) | Anti-Human CD14 Recombinant Antibody scFv Fragment (scFv2F9) | WB, FC, Block | Human antibody |
| TAB-1589CL-F(E) | Anti-Human CD14 Recombinant Antibody Fab Fragment (scFv2F9) | WB, FC, Block | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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