What is an "scFv" and what are its advantages?

An scFv, or single-chain variable fragment, is a small, recombinant antibody format. It consists of the variable regions of the heavy (VH) and light (VL) chains of an antibody, joined by a flexible peptide linker. Its main advantages are its small size (which can be useful for certain assays) and its production in systems like E. coli, which this one is.

What applications is this anti-CD14 scFv validated for?

This recombinant human scFv antibody is specifically validated for use in WB. It is designed to target human CD14, a key co-receptor in the innate immune system, which is widely studied in immunology research for its role in recognizing bacterial lipopolysaccharide (LPS).

Anti-Human CD14 Recombinant Antibody scFv Fragment (ZCH-7-2F9)

CAT#: TAB-1587CL-S(P)

This murine anti-human acceptor antibody can be used as a drug in treatment of acute monocytic leukemia.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line SiHa

Immunofluorescent staining of human cell line SiHa shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1887/1183_E12_3_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1887/159971_B_8_5.jpg

Normal Tissue Figure 3 Colon

Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1887/159971_A_7_3.jpg

Normal Tissue Figure 4 Testis

Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1887/159971_A_4_6.jpg

Normal Tissue Figure 5 Lymph node

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1887/159971_A_9_8.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (A549, CACO-2, SiHa)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000170458-CD14

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Specifications

Immunogen
Leukemia cells

Host Species
Mouse

Specificity
Human

Clone
ZCH-7-2F9

Related Disease
Acute monocytic leukemia

Target

Alternative Names
CD14; CD14 molecule; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein

Gene ID
929

UniProt ID
P08571

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Breast cancer biomarkers at key points during disease progression

Good CD14 scFv

This product is a human scFv specific for human CD14. We use it in a custom WB setup, and it works well for this application. The E. coli expression system means it's a simple, non-glycosylated fragment, which is perfectly suitable for a binding assay like ours.

Great for WB

We needed a small antibody fragment for our CD14 research. This is a human antibody fragment validated for WB. It's a good, specific reagent for detecting human CD14 in this format. The small size and human origin are key benefits.

Q&As

What is an "scFv" and what are its advantages?

A: An scFv, or single-chain variable fragment, is a small, recombinant antibody format. It consists of the variable regions of the heavy (VH) and light (VL) chains of an antibody, joined by a flexible peptide linker. Its main advantages are its small size (which can be useful for certain assays) and its production in systems like E. coli, which this one is.
What applications is this anti-CD14 scFv validated for?

A: This recombinant human scFv antibody is specifically validated for use in WB. It is designed to target human CD14, a key co-receptor in the innate immune system, which is widely studied in immunology research for its role in recognizing bacterial lipopolysaccharide (LPS).

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-1587CL-S(P).pdf

MSDS

MSDS - TAB-1587CL-S(P).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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