Afuco™ Anti-Human CD48 ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-124CL)
Anti-CD48 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This is an antibody directed against the CD48 antigen has a strong anti-tumour effect in an animal model. The anti-tumour effect has been demonstrated in an animal model where treatment of mice containing tumour cells with an anti-CD48 antibody gave long term survival (cures) over those treated with a control antibody.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55146/1674_C10_33_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55146/1674_C10_33_selected.jpg
Figure 2 High expression in tonsil.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/ihc_selected.jpg
Figure 3 Low expression in cerebral cortex.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_B_7_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_B_7_5_val_selected.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_9_8.jpg
(Germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_9_8.jpg
Figure 5 Tonsil
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_4_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_4_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117091-CD48
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117091-CD48
Specifications
- Host Species
- Mouse
- Derivation
- Chimeric (human/mouse)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- CD48; CD48 molecule; BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102; CD48 antigen; TCT.1; BCM1 surface antigen; SLAM family member 2; leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); signaling lymphocytic activation molecule 2
- Gene ID
- 962
- UniProt ID
- A0A087X1S7
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CD48"
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-132CL | Anti-Human CD48 Recombinant Antibody | ELISA, Inhib, FuncS | Antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-304LC | Human Anti-CD48 Recombinant Antibody (TAB-304LC) | ELISA, FuncS | Human IgG4 |
| TAB-305LC | Mouse Anti-CD48 Recombinant Antibody (TAB-305LC) | ELISA | Mouse IgG |
| TAB-306LC | Human Anti-CD48 Recombinant Antibody (TAB-306LC) | ELISA | Human IgG |
| TAB-304LC-S(P) | Human Anti-CD48 Recombinant Antibody (TAB-304LC-S(P)); scFv Fragment | ELISA | Human scFv |
| TAB-305LC-S(P) | Mouse Anti-CD48 Recombinant Antibody (TAB-305LC-S(P)); scFv Fragment | ELISA | Mouse scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-307LC | Mouse Anti-CD48 Recombinant Antibody (TAB-307LC) | ELISA, Cyt, CDC | Mouse IgG2a |
| TAB-307LC-S(P) | Mouse Anti-CD48 Recombinant Antibody; scFv Fragment (TAB-307LC-S(P)) | ELISA | Mouse scFv |
| TAB-307LC-F(E) | Mouse Anti-CD48 Recombinant Antibody; Fab Fragment (TAB-307LC-F(E)) | ELISA | Mouse Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-390CQ | Hamster Anti-CD48 Recombinant Antibody (clone HM48-1) | FC, IP, Costim, Block | Hamster IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0566 | Hi-Affi™ Rabbit Anti-CD48 Recombinant Antibody (clone DS566AB) | WB, IHC, ICC, IP | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1325LY-S(P) | Human Anti-CD48 Recombinant Antibody; scFv Fragment (HPAB-1325LY-S(P)) | ELISA | Human scfv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1325LY-F(E) | Human Anti-CD48 Recombinant Antibody; Fab Fragment (HPAB-1325LY-F(E)) | ELISA | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1648CQ | Mouse Anti-CD48 Recombinant Antibody (clone OX78) | IP, Block, FC | Mouse IgG2a |
| FAMAB-1650CQ | Mouse Anti-CD48 Recombinant Antibody (clone OX45) | Block, FC | Mouse IgG1 |
| ZG-0135U | Rabbit Anti-CD48 Recombinant Antibody (clone 7E1) | ELISA, WB | Rabbit IgG |
| VS3-XY357 | Mouse Anti-CD48 Recombinant Antibody, FITC (clone 4A156-4H9) | FC, IF | Mouse IgG1 |
| VS3-XY358 | Mouse Anti-CD48 Recombinant Antibody, PE (clone 4A156-4H9) | FC, IF | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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