Anti-Human CD52 Recombinant Antibody (ANT1034)
CAT#: TAB-315LC
This product is a recombinant monoclonal antibody against CD52. This study demonstrates that it binds strongly to CD52-expressing cells and is more effective in directing antibody-dependent and complement-dependent cellular cytotoxicity. It is a humanized antibody with potential use in the treatment studies of chronic lymphocytic leukemia and autoimmune diseases.
Published Data
Gene Expression
FuncS
Figure 1 Kaplan-Meier survival curves for the in vivo assessment of ANT1034 and alemtuzumab.
Antibodies were assessed in the Raji human Burkitt lymphoma SCID mouse model. Antibodies were administered on alternate days for seven doses starting 3 days post-injection of tumour cells. Efficacy was determined by comparing the median times to endpoint (either death, or euthanasia for advanced tumour progression).
Holgate, R. G., Weldon, R., Jones, T. D., & Baker, M. P. (2015). Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity. PLoS One, 10(9), e0138123.
FuncS
Figure 2 CD4+ Episcreen™ T cell proliferation responses to ANT1034, alemtuzumab and chimeric 2E8.
Holgate, R. G., Weldon, R., Jones, T. D., & Baker, M. P. (2015). Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity. PLoS One, 10(9), e0138123.
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RNA Expression
Figure 1 RNA cell line category: Group enriched (Daudi, REH, U-266/84, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169442-CD52
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- ANT1034
- Applications
- ELISA, FC, FuncS
- Related Disease
- Chronic lymphocytic leukaemia, Autoimmune disease
Applications
- Application Notes
- This antibody has been tested for use in Function Assay. Please see the Published Data for further information.
Target
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prompt delivery and careful support
Quick shipment, and friendly customer support was there to answer any queries I had about the storage buffer.
Effective at Various pHs
When stability was evaluated at several pH levels, it stayed specific and active at all of the values.
User-friendly Aliquoting
The process of aliquotting was easy, and the smaller aliquots did not degrade over an extended period of time.
Q&As
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How should I use the antibody so that it doesn't get contaminated?
A: Use sterile procedures and personal protective equipment when handling the antibody to prevent contamination and guarantee accuracy in applications.
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Are there any particulars to be aware of when utilizing the antibody in research?
A: Yes, to guarantee accurate and repeatable findings, strictly adhere to procedures, prevent cross-contamination, and maintain suitable storage conditions.
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Can animals be treated with the antibody?
A: A portion of the antibody may be utilized in veterinary settings, but it's crucial to select formulations that have been especially created and examined for usage with animals.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone ANT1034"
- CAT
- Product Name
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Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1223z | Mouse Anti-CD52 Recombinant Antibody (clone 20C9) | WB, ELISA, FC, IHC, FuncS | Mouse IgG1, κ |
| MOB-0508CT | Mouse Anti-CD52 Recombinant Antibody (clone IJ297) | FC, IHC-P | Mouse IgG2b |
| HPAB-1835-FY | Human Anti-CD52 Recombinant Antibody (clone 4D9) | ELISA | Human IgG |
| HPAB-1836-FY | Human Anti-CD52 Recombinant Antibody (clone 5E3) | ELISA | Human IgG |
| FAMAB-1070CQ | Human Anti-CD52 Recombinant Antibody (clone HI186) | IHC-P, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-311LC | Humanized Anti-Human CD52 Recombinant Antibody | ELISA | Humanized antibody |
| TAB-311LC-S(P) | Humanized Anti-Human CD52 Recombinant Antibody scFv Fragment | ELISA | Humanized antibody |
| TAB-315LC-S(P) | Anti-Human CD52 Recombinant Antibody scFv Fragment (ANT1034) | FC, ELISA | Humanized antibody |
| TAB-311LC-F(E) | Humanized Anti-Human CD52 Recombinant Antibody Fab Fragment | ELISA | Humanized antibody |
| TAB-315LC-F(E) | Anti-Human CD52 Recombinant Antibody Fab Fragment (ANT1034) | FC, ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-312LC | Anti-Human CD52 Recombinant Antibody (CF1D12) | FuncS | |
| TAB-313LC | Mouse Anti-CD52 Recombinant Antibody (TAB-313LC) | ELISA, FC | Mouse IgG |
| TAB-312LC-S(P) | Anti-Human CD52 Recombinant Antibody scFv Fragment (CF1D12) | ELISA | |
| TAB-313LC-S(P) | Mouse Anti-CD52 Recombinant Antibody; scFv Fragment (TAB-313LC-S(P)) | FC, ELISA | Mouse scFv |
| TAB-312LC-F(E) | Anti-Human CD52 Recombinant Antibody Fab Fragment (CF1D12) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-314LC | Human Anti-CD52 Recombinant Antibody (TAB-314LC) | FC, ELISA | Chimeric (mouse/human) IgG1 |
| TAB-314LC-S(P) | Mouse Anti-CD52 Recombinant Antibody; scFv Fragment (TAB-314LC-S(P)) | FC, ELISA | Mouse scFv |
| TAB-314LC-F(E) | Human Anti-CD52 Recombinant Antibody; Fab Fragment (TAB-314LC-F(E)) | FC, ELISA | Chimeric (mouse/human) Fab |
| TAB-469CQ | Anti-Canine CD52 Recombinant Antibody (Tamtuvetmab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-038LC | Recombinant Anti-Human CD52 Antibody (Fab glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0568 | Hi-Affi™ Rabbit Anti-CD52 Recombinant Antibody (clone DS568AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-469CQ | Afuco™ Anti-CD52 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-469CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0748-FY-F(E) | Mouse Anti-CD52 Recombinant Antibody (clone HI52); scFv Fragment | Inhib | Mouse scFv |
| HPAB-0387-FY-S(P) | Human Anti-CD52 Recombinant Antibody; scFv Fragment (HPAB-0387-FY-S(P)) | WB | Human scFv |
| HPAB-0940WJ-S(P) | Mouse Anti-CD52 Recombinant Antibody; scFv Fragment (HPAB-0940WJ-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0941WJ-S(P) | Mouse Anti-CD52 Recombinant Antibody; scFv Fragment (HPAB-0941WJ-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0942WJ-S(P) | Mouse Anti-CD52 Recombinant Antibody; scFv Fragment (HPAB-0942WJ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0748-FY-S(P) | Mouse Anti-CD52 Recombinant Antibody (clone HI52); Fab Fragment | Inhib | Mouse Fab |
| HPAB-0107-WJ-F(E) | Human Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0107-WJ-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0398-YJ-F(E) | Human Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0398-YJ-F(E)) | ELISA, Inhib, Immunocontraception | Human Fab |
| HPAB-0387-FY-F(E) | Human Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0387-FY-F(E)) | WB | Humanized Fab |
| HPAB-1835-FY-S(P) | Human Anti-CD52 Recombinant Antibody (clone 4D9); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC121 | Human Anti-CD52 Recombinant Antibody Hexamer (VS-0924-YC121), CDC Enhanced | ELISA, FC, CDC | Antibody hexamer |
| VS-0924-YC122 | Mouse Anti-CD52 Recombinant Antibody Hexamer (VS-0924-YC122), CDC Enhanced | Inhib, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY57 | Human Anti-CD52 (clone HI52) scFv-Fc Chimera | Inhib, ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC140 | Recombinant Anti-CD52 Vesicular Antibody, EV Displayed (VS-0425-YC140) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1197 | Anti-CD52 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1198 | Anti-Human CD52 Immunohistochemistry Kit | IHC |
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