Anti-Human CD52 Recombinant Antibody (ANT1034) (CAT#: TAB-315LC)
This product is a recombinant monoclonal antibody against CD52. This study demonstrates that it binds strongly to CD52-expressing cells and is more effective in directing antibody-dependent and complement-dependent cellular cytotoxicity. It is a humanized antibody with potential use in the treatment studies of chronic lymphocytic leukemia and autoimmune diseases.
Specific Inquiry
FuncS
Figure 1 Kaplan-Meier survival curves for the in vivo assessment of ANT1034 and alemtuzumab.
Antibodies were assessed in the Raji human Burkitt lymphoma SCID mouse model. Antibodies were administered on alternate days for seven doses starting 3 days post-injection of tumour cells. Efficacy was determined by comparing the median times to endpoint (either death, or euthanasia for advanced tumour progression).
Holgate, R. G., Weldon, R., Jones, T. D., & Baker, M. P. (2015). Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity. PLoS One, 10(9), e0138123.
FuncS
Figure 2 CD4+ Episcreen™ T cell proliferation responses to ANT1034, alemtuzumab and chimeric 2E8.
Holgate, R. G., Weldon, R., Jones, T. D., & Baker, M. P. (2015). Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity. PLoS One, 10(9), e0138123.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- ANT1034
- Applications
- ELISA, FC, FuncS
- Related Disease
- Chronic lymphocytic leukaemia, Autoimmune disease
Applications
- Application Notes
- This antibody has been tested for use in Function Assay. Please see the Published Data for further information.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1223z | Mouse Anti-CD52 Recombinant Antibody (clone 20C9) | WB, ELISA, FC, IHC, FuncS | Mouse IgG1, κ |
| MOB-0508CT | Mouse Anti-CD52 Recombinant Antibody (clone IJ297) | FC, IHC-P | Mouse IgG2b |
| FAMAB-0045YC | Rat Anti-CD52 Recombinant Antibody (clone YTH 34.5HL) | ELISA | Rat IgG2a, κ |
| HPAB-0748-FY | Mouse Anti-CD52 Recombinant Antibody (clone HI52) | Inhib | Mouse IgG |
| HPAB-0940WJ | Mouse Anti-CD52 Recombinant Antibody (HPAB-0940WJ) | ELISA, FC | Mouse IgG3 |
Customer Reviews and Q&As
Customer Review
Q&As
prompt delivery and careful support
Quick shipment, and friendly customer support was there to answer any queries I had about the storage buffer.
Effective at Various pHs
When stability was evaluated at several pH levels, it stayed specific and active at all of the values.
User-friendly Aliquoting
The process of aliquotting was easy, and the smaller aliquots did not degrade over an extended period of time.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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