Anti-CD56 (huN901)-SPP-DM1 ADC (IMGN901/Lorvotuzumab mertansine) (CAT#: ADC-L017)

• Antibody Overview
• Humanized IgG1k antibody J2898A (Anti-CD56)

• Clone
• huN901

• Antibody Conjugation
• Humanized

• Linker
• SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)

• Linker Class/Description
• Class: Chemically cleavable linker-Disulfide linker
  Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

• Drug
• DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

• Introduction
• This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants.

• Alternative Names
• CD56; NCAM; MSK39

• Gene ID
• 4684

• UniProt ID
• P13591

• ADC-065LCT
• Anti-CD56 (huN901)-SPP-DM1 ADC

• ADC-002LZY
• Anti-CD56 (clone huN901)-SPP-DM1 ADC

• ADC-165LZY
• Anti-CD56 (clone huN901)-SPP-[3H]DM1 ADC

• ADC-166LZY
• Anti-CD56 (clone huN901)-SMCC-[3H]DM1 ADC

• ADC-167LZY
• Anti-CD56 (clone huN901)-SPDB-[3H]DM1 ADC

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