anti-NCAM1 immunotoxin N901 (IgG)-PAP (CAT#: AGTO-L037P)
This immunotoxin was achieved by conjugating/fusing the Anti-NCAM1 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to small-cell lung cancer (SCLC) cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of small-cell lung cancer (SCLC).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/if_selected.jpg
Figure 2 Cerebral cortex
(Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_B_9_5.jpg
(Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_B_9_5.jpg
Figure 3 Colon
(Peripheral nerve/ganglion
Staining:
High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_A_8_3.jpg
(Peripheral nerve/ganglion
Staining:
High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_A_8_3.jpg
Figure 4 Soft tissue
(Peripheral nerve
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_B_1_7.jpg
(Peripheral nerve
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_B_1_7.jpg
Figure 5 RNA cell line category: Cell line enhanced (HEL, RH-30, SCLC-21H, SH-SY5Y, U-138 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000149294-NCAM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000149294-NCAM1
Figure 5 RNA cell line category: Cell line enhanced (HEL, RH-30, SCLC-21H, SH-SY5Y, U-138 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000149294-NCAM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000149294-NCAM1
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- N901
- Molecule Class
- L kappa; IgG1-PAP
- Toxin Description
- Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Small-cell lung cancer (SCLC)
Target
- Alternative Names
- NCAM1; neural cell adhesion molecule 1; CD56; NCAM; MSK39; neural cell adhesion molecule, NCAM; antigen recognized by monoclonal antibody 5.1H11; Small-cell lung cancer; SCLC; Pokeweed Antiviral Protein; Pokeweed; PAP
- Gene ID
- 4684
- UniProt ID
- P13591
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1164z | Mouse Anti-NCAM1 Recombinant Antibody (clone 19C11) | ELISA, FC, ICC, IF, IHC, WB | Mouse IgG1, κ |
| MOB-0287MZ | Recombinant Mouse Anti-Human Neural Cell Adhesion Molecule 1 Antibody (clone 124D4) | IHC | Mouse antibody |
| MRO-1756-CN | Rabbit Anti-NCAM1 Polyclonal Antibody (MRO-1756-CN) | WB, IF | Rabbit IgG |
| HPAB-N0187-YC | Human Anti-NCAM1 Recombinant Antibody (clone Promiximab) | ELISA, FC, WB, FuncS | Human IgG |
| FAMAB-1226CQ | Human Anti-NCAM1 Recombinant Antibody (clone NCAM12.19) | ELISA | Human IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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