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anti-NCAM1 immunotoxin N901 (IgG)-PAP (AGTO-L037P)

This immunotoxin was achieved by conjugating/fusing the Anti-NCAM1 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to small-cell lung cancer (SCLC) cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of small-cell lung cancer (SCLC).      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
N901
Molecule Class
L kappa; IgG1-PAP
Toxin Description
Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Small-cell lung cancer (SCLC)
Target
Alternative Names
NCAM1; neural cell adhesion molecule 1; CD56; NCAM; MSK39; neural cell adhesion molecule, NCAM; antigen recognized by monoclonal antibody 5.1H11; Small-cell lung cancer
Entrez Gene ID
4684
UniProt ID
P13591

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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