anti-NCAM1 immunotoxin N901 (IgG)-RTA (CAT#: AGTO-L037R)

This immunotoxin was achieved by conjugating/fusing the Anti-NCAM1 monoclonal antibody to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to small-cell lung cancer (SCLC) cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of small-cell lung cancer (SCLC).


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • N901
  • Molecule Class
  • L kappa; IgG1-RTA
  • Toxin Description
  • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Small-cell lung cancer (SCLC)

Target

  • Alternative Names
  • NCAM1; neural cell adhesion molecule 1; CD56; NCAM; MSK39; neural cell adhesion molecule, NCAM; antigen recognized by monoclonal antibody 5.1H11; Small-cell lung cancer; SCLC; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Humanized Antibody

CAT Product Name Application Type
TAB-188 Humanized Anti-NCAM1 Recombinant Antibody (clone Lorvotuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC Humanized (from mouse) IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-L037P anti-NCAM1 immunotoxin N901 (IgG)-PAP Cytotoxicity assay, Functional assay

Blocking Antibody

CAT Product Name Application Type
NEUT-1761CQ Recombinant Mouse Anti-NCAM1 Antibody (MEM188) FC, IHC-Fr, ICC, Separation, BL IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4549 Hi-Affi™ Recombinant Rabbit Anti-NCAM1 Monoclonal Antibody (TH59DS) WB, IF, ICC, FC IgG

Neuroscience Antibody

CAT Product Name Application Type
NS-054CN Mouse Anti-NCAM1 Recombinant Antibody (clone 5A2) ELISA, WB, IP, FC, FuncS Mouse IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-188 Afuco™ Anti-NCAM1 ADCC Recombinant Antibody (Lorvotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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