Anti-CSPG4 immunotoxin (IgG)-Sap (CAT#: AGTO-G014S)

This immunotoxin was achieved by conjugating/fusing the Anti-CSPG4 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of rhabdomyosarcoma.


Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Molecule Class
  • IgG-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • rhabdomyosarcoma

Target

  • Alternative Names
  • CSPG4; chondroitin sulfate proteoglycan 4; NG2; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG; chondroitin sulfate proteoglycan NG2; melanoma chondroitin sulfate proteoglycan; melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4 (melanoma-associated); saporin; saporin-6; saporin-S11; SAP

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "CSPG4"

Immunotoxin

CAT Product Name Application Type
AGTO-G013E Anti-CSPG4 immunotoxin (scFv)-PE Cytotoxicity assay, Function study
AGTO-G013S Anti-CSPG4 immunotoxin (scFv)-Sap Cytotoxicity assay, Function study
AGTO-G014E Anti-CSPG4 immunotoxin (IgG)-PE Cytotoxicity assay, Function study

Blocking Antibody

CAT Product Name Application Type
NEUT-550CQ Mouse Anti-CSPG4 Recombinant Antibody (clone 9.2.27) EM, Block, IP, FC, ICC, IF Mouse IgG2a

Rabbit Monoclonal Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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