Anti-Human CTGF Recombinant Antibody (FG-3019) (CAT#: TAB-194CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human CTGF. FG-3019 is an investigational therapeutic antibody to inhibit the activity of connective tissue growth factor (CTGF), a common factor in chronic fibrotic and proliferative disorders characterized by persistent and excessive scarring that can lead to organ dysfunction and failure. The clinical studies of FG-3019 in idiopathic pulmonary fibrosis, pancreatic cancer, and liver fibrosis show that, it has been well tolerated, with no apparent safety signals, in more than ten clinical studies and more than 340 treated patients to date.
Specific Inquiry
WB
Figure 1 Recombinant human CTGF was analyzed by western blot using FG-3019 antibodies.
FG-3019 specifically bound CTGF without crossreacting with CYR61 or NOV.
Wang, Q., Usinger, W., Nichols, B., Gray, J., Xu, L., Seeley, T. W., ... & Lin, A. (2011). Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease. Fibrogenesis & tissue repair, 4(1), 4.
IHC
Figure 2 Hepatic and renal fibrosis in mice receiving transforming growth factor (TGF)-band connective tissue growth factor (CTGF) is ameliorated by FG-3019 treatment.
All agents were administered daily for 20 days beginning one day after birth. Arrowsindicate regions of robust capsular fibrosis inhibited by FG-3019 treatment. Representative images are shown (all haematoxylin and eosin,original magnification × 200).
Wang, Q., Usinger, W., Nichols, B., Gray, J., Xu, L., Seeley, T. W., ... & Lin, A. (2011). Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease. Fibrogenesis & tissue repair, 4(1), 4.
IF
Figure 3 Influence of neutralizing CTGF-specific mAb on CTGF-expressing cells in vitro and in vivo.
TUNEL of paraffin-embedded tumor sections of CTGF-expressing (CE8) xenografts treated with either CTGF-specific mAb FG-3019 were used to assess the influence of CTGF antibody on apoptosis (green, TUNEL-positive apoptotic cells; ×200 magnification).
Dornhöfer, N., Spong, S., Bennewith, K., Salim, A., Klaus, S., Kambham, N., ... & Höckel, M. (2006). Connective tissue growth factor–specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer research, 66(11), 5816-5827.
IHC
Figure 4 Influence of neutralizing CTGF-specific mAb on CTGF-expressing cells in vitro and in vivo.
CD31 staining of paraffin-embedded tumor sections of CTGF-expressing (CE8) xenografts treated with either CTGF-specific mAb FG-3019 or vehicle, were used to assess blood vessel density (brown-green, endothelial cells, ×100 magnification).
Dornhöfer, N., Spong, S., Bennewith, K., Salim, A., Klaus, S., Kambham, N., ... & Höckel, M. (2006). Connective tissue growth factor–specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer research, 66(11), 5816-5827.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- WB, IHC, IF
- Related Disease
- Idiopathic pulmonary fibrosis
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- Store at -20°C. Open under aseptic conditions.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Immunohistochemistry and Immunofluorescence.
Target
- Alternative Names
- CTGF; connective tissue growth factor; CCN2; NOV2; HCS24; IGFBP8; IBP-8; IGFBP-8; CCN family member 2; IGF-binding protein 8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8
- Gene ID
- 1490
- UniProt ID
- P29279
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
Mouse Antibody
Human Antibody
Fc Glycosylation
scFv Fragment Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1576z | Mouse Anti-CTGF Recombinant Antibody (clone 32G9) | ELISA, IHC | Mouse IgG1 |
| HPAB-0181-YC | Human Anti-CTGF Recombinant Antibody (HPAB-0181-YC) | ELISA, FuncS | Human IgG |
| MRO-1793-CN | Rabbit Anti-CTGF Polyclonal Antibody (MRO-1793-CN) | WB, IF, IHC | Rabbit IgG |
Customer Reviews and Q&As
Customer Review
Q&As
-
Reliable and Robust
This recombinant antibody is incredibly reliable and holds up well under various conditions. It's robust enough for multiple cycles of use. -
Good Value
Considering the robust performance and the cost, this antibody is a good value. It has saved us resources while improving our data quality. -
Optimal Concentration
The concentration provided is just right for several types of assays. We appreciate not having to dilute or concentrate it ourselves.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-194CL, RRID: AB_3111864)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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