Human Anti-CTGF scFv-Fc Chimera (VS-0425-FY95)
CAT#: VS-0425-FY95
This scFv-Fc fusion protein targets CTGF (Connective tissue growth factor), a cytokine involved in fibrosis and tissue repair. By neutralizing CTGF, it can reduce excessive fibrosis and tissue scarring, making it a promising candidate for treating fibrotic diseases such as idiopathic pulmonary fibrosis and cirrhosis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31074/564_D9_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human stomach, upper
Immunohistochemical staining of human stomach, upper shows moderate positivity in plasma and stromal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31075/ihc_selected.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5123/15554_A_9_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5123/15554_B_7_5.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5123/15554_A_8_4.jpg
Normal Tissue
Figure 6 Smooth muscle
Smooth muscle cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5123/15554_B_5_7.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (EFO-21, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118523-CTGF
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Specifications
- Immunogen
- Human CTGF/IGFBP-8 as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CTGF
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Systemic Scleroderma and Renal Fibrosis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Connective Tissue Growth Factor; Hypertrophic Chondrocyte-Specific Protein 24; Insulin-Like Growth Factor-Binding Protein 8; IGF-Binding Protein 8; CCN Family Member 2; IGFBP-8
- Gene ID
- 1490
- UniProt ID
- P29279
- Long Name
- Connective Tissue Growth Factor
- Sequence Similarities
- Belongs to the CCN family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn28, Thr193, and Asn225
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites, 2 O-linked glycans (3 sites)
- Protein Refseq
- NP_001892.2
- Function
- Major connective tissue mitoattractant secreted by vascular endothelial cells.
Promotes proliferation and differentiation of chondrocytes.
Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells.
Enhances fibroblast growth factor-induced DNA synthesis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CTGF"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1576z | Mouse Anti-CTGF Recombinant Antibody (clone 32G9) | ELISA, IHC | Mouse IgG1 |
| HPAB-0181-YC | Human Anti-CTGF Recombinant Antibody (HPAB-0181-YC) | ELISA, FuncS | Human IgG |
| MRO-1793-CN | Rabbit Anti-CTGF Polyclonal Antibody (MRO-1793-CN) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-080MZ | Mouse Anti-CTGF Recombinant Antibody (TAB-080MZ) | ELISA | Mouse IgG |
| TAB-080MZ-S(P) | Mouse Anti-CTGF Recombinant Antibody; scFv Fragment (TAB-080MZ-S(P)) | ELISA | Mouse scFv |
| TAB-080MZ-F(E) | Mouse Anti-CTGF Recombinant Antibody; Fab Fragment (TAB-080MZ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-081MZ | Human Anti-CTGF Recombinant Antibody (TAB-081MZ) | ELISA | Human IgG |
| TAB-082MZ | Human Anti-CTGF Recombinant Antibody (TAB-082MZ) | ELISA | Human IgG |
| TAB-081MZ-S(P) | Human Anti-CTGF Recombinant Antibody; scFv Fragment (TAB-081MZ-S(P)) | ELISA | Human scFv |
| TAB-082MZ-S(P) | Human Anti-CTGF Recombinant Antibody; scFv Fragment (TAB-082MZ-S(P)) | ELISA | Human scFv |
| TAB-443CQ | Anti-Human CTGF Recombinant Antibody (TAB-443CQ) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-119LC | Recombinant Anti-Human CTGF Antibody (Fc glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0181-YC-S(P) | Human Anti-CTGF Recombinant Antibody; scFv Fragment (HPAB-0181-YC-S(P)) | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0181-YC-F(E) | Human Anti-CTGF Recombinant Antibody; Fab Fragment (HPAB-0181-YC-F(E)) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-443CQ | Afuco™ Anti-CTGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-443CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY573 | Anti-CTGF Immunohistochemistry Kit | IHC | |
| VS-0525-XY1759 | Anti-Human CTGF Immunohistochemistry Kit | IHC |
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