Recombinant Mouse Anti-DENV E protein Antibody (E53) (CAT#: PABW-146)
Recombinant Mouse Antibody (E53) is capable of binding to DENV E protein, expressed in Chinese Hamster Ovary cells (CHO). E53, a highly cross-reactive fusion-loop antibodies, bind to a conserved region of the flavivirus E protein and are generally weakly neutralizing. Because of their cross-reactivity, fusion-loop antibodies generated during a primary DENV infection should bind to partially or mostly immature viruses produced during a secondary infection. Therefore, these fusion-loop antibodies may promote ADE of infection by augmenting attachment and/or entry of partially immature virions. Indeed, it has been shown recently that fusion-loop-specific MAbs promote ADE in animals.
Specific Inquiry
ELISA
Figure 1 Mouse Anti-DENV E Recombinant Antibody (PABW-146) in ELISA
ELISA analysis of PABW-146 was performed by coating with DENV protein (His tag). Then blocked with BSA and incubated with PABW-146-mIgG2a. The HRP conjugated Anti-Mouse IgG Fc as a secondary antibody (1: 2000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
Specifications
- Immunogen
- DENV E protein
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native DENV E protein
- Species Reactivity
- DENV, WNV
- Clone
- E53
- Applications
- Inhib
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Inhibition.
Target
- Alternative Names
- DENV; Dengue virus; E; E protein
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0001-YC-S(P) | Recombinant Human Anti-E protein Antibody scFv Fragment (7A) | ELISA, WB, Neut, IP | Human scFv |
| FAMAB-0111CQ-S(P) | Recombinant Human Anti-E protein Antibody scFv Fragment (82.11) | ELISA, Neut | Human scFv |
| FAMAB-0112CQ-S(P) | Recombinant Human Anti-E protein Antibody scFv Fragment (87.1) | ELISA, Neut | Human scFv |
| FAMAB-0113CQ-S(P) | Recombinant Mouse Anti-E protein Antibody scFv Fragment (E18) | ELISA, Neut | Mouse scFv |
| FAMAB-0114CQ-S(P) | Recombinant Mouse Anti-E protein Antibody scFv Fragment (E28) | ELISA, Neut | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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