Recombinant Mouse Anti-DENV E protein Antibody (E53) (CAT#: PABW-146)
Recombinant Mouse Antibody (E53) is capable of binding to DENV E protein, expressed in Chinese Hamster Ovary cells (CHO). E53, a highly cross-reactive fusion-loop antibodies, bind to a conserved region of the flavivirus E protein and are generally weakly neutralizing. Because of their cross-reactivity, fusion-loop antibodies generated during a primary DENV infection should bind to partially or mostly immature viruses produced during a secondary infection. Therefore, these fusion-loop antibodies may promote ADE of infection by augmenting attachment and/or entry of partially immature virions. Indeed, it has been shown recently that fusion-loop-specific MAbs promote ADE in animals.
Specific Inquiry
Inhib
Figure 1 Neutralizing activity of MAbs in cell culture against different preparations of WNV.
E53 was tested for neutralization of C6/36 cell-derived WNV (50 to 125 PFU) by classical PRNT assay on BHK21-15 cells.
Vogt, M. R., Dowd, K. A., Engle, M., Tesh, R. B., Johnson, S., Pierson, T. C., & Diamond, M. S. (2011). Poorly neutralizing cross-reactive antibodies against the fusion loop of West Nile virus envelope protein protect in vivo via Fcγ receptor and complement-dependent effector mechanisms. Journal of virology, 85(22), 11567-11580.
Specifications
- Immunogen
- DENV E protein
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native DENV E protein
- Species Reactivity
- DENV, WNV
- Clone
- E53
- Applications
- Inhib
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Inhibition.
Target
- Alternative Names
- DENV; Dengue virus; E; E protein
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-147 | Recombinant Mouse Anti-WNV E protein Antibody (E53) | Neut, Activ | IgG |
| FAMAB-0001YC | Recombinant Human Anti-E protein Antibody (7A) | ELISA, WB, Neut, IP | Human IgG |
| FAMAB-0114CQ | Recombinant Human Anti-E protein Antibody (E28) | ELISA, Neut, FuncS | Chimeric (mouse/human) IgG1 |
| FAMAB-0115CQ | Recombinant Human Anti-E protein Antibody (E44) | ELISA, Neut, FuncS | Chimeric (mouse/human) IgG1 |
| FAMAB-0116CQ | Recombinant Human Anti-E protein Antibody (E60) | ELISA, Neut, FuncS | Chimeric (mouse/human) IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-153 | Recombinant Mouse Anti-JEV E protein Antibody Fab Fragment (E3.3) | WB, Neut | Fab |
| FAMAB-0001-YC-S(P) | Recombinant Human Anti-E protein Antibody scFv Fragment (7A) | ELISA, WB, Neut, IP | Human scFv |
| HPAB-M0057-YC-S(P) | Recombinant Human Anti-E Protein Antibody scFv Fragment (Z3L1) | ELISA, FC, Neut | Human scFv |
| HPAB-M0058-YC-S(P) | Recombinant Human Anti-E Protein Antibody scFv Fragment (Z20) | ELISA, FC, Neut | Human scFv |
| HPAB-M0059-YC-S(P) | Recombinant Human Anti-E Protein Antibody scFv Fragment (Z23) | ELISA, FC, Neut | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0001-YC-F(E) | Recombinant Human Anti-E protein Antibody Fab Fragment (7A) | ELISA, WB, Neut, IP | Human Fab |
| HPAB-M0057-YC-F(E) | Recombinant Human Anti-E Protein Antibody Fab Fragment (Z3L1) | ELISA, FC, Neut | Human Fab |
| HPAB-M0058-YC-F(E) | Recombinant Human Anti-E Protein Antibody Fab Fragment (Z20) | ELISA, FC, Neut | Human Fab |
| HPAB-M0059-YC-F(E) | Recombinant Human Anti-E Protein Antibody Fab Fragment (Z23) | ELISA, FC, Neut | Human Fab |
| HPAB-M0254-YC-F(E) | Recombinant Humanized Anti-E Protein Antibody Fab Fragment (Z6) | FC, Neut | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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