Recombinant Mouse Anti-DENV E protein Antibody (E53) (CAT#: PABW-146)
Recombinant Mouse Antibody (E53) is capable of binding to DENV E protein, expressed in Chinese Hamster Ovary cells (CHO). E53, a highly cross-reactive fusion-loop antibodies, bind to a conserved region of the flavivirus E protein and are generally weakly neutralizing. Because of their cross-reactivity, fusion-loop antibodies generated during a primary DENV infection should bind to partially or mostly immature viruses produced during a secondary infection. Therefore, these fusion-loop antibodies may promote ADE of infection by augmenting attachment and/or entry of partially immature virions. Indeed, it has been shown recently that fusion-loop-specific MAbs promote ADE in animals.
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ELISA
Figure 1 Mouse Anti-DENV E Recombinant Antibody (PABW-146) in ELISA
ELISA analysis of PABW-146 was performed by coating with DENV protein (His tag). Then blocked with BSA and incubated with PABW-146-mIgG2a. The HRP conjugated Anti-Mouse IgG Fc as a secondary antibody (1: 2000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
Specifications
- Immunogen
- DENV E protein
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native DENV E protein
- Species Reactivity
- DENV, WNV
- Clone
- E53
- Applications
- Inhib
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Inhibition.
Target
- Alternative Names
- DENV; Dengue virus; E; E protein
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibodies
Fab Antibodies
ScFv Antibodies
Biparatopic Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-147 | Recombinant Mouse Anti-WNV E protein Antibody (E53) | Neut, Activ | IgG |
| FAMAB-0001YC | Recombinant Human Anti-E protein Antibody (7A) | ELISA, WB, Neut, IP | Human IgG |
| HPAB-M0057-YC | Recombinant Human Anti-E Protein Antibody (Z3L1) | ELISA, FC, Neut | Human IgG |
| HPAB-M0058-YC | Recombinant Human Anti-E Protein Antibody (Z20) | ELISA, FC, Neut | Human IgG |
| HPAB-M0059-YC | Recombinant Human Anti-E Protein Antibody (Z23) | ELISA, FC, Neut | Human IgG |
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For Research Use Only. Not For Clinical Use.
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