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  • Afuco™ Anti-Human F11R ADCC Recombinant Antibody, ADCC Enhanced

Afuco™ Anti-Human F11R ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-241CL)

Anti-F11R ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. The anti-JAM-A antibodies are capable of inhibiting the proliferation of tumor cells in vitro and/or in vivo and using for the treatment of cancer.

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  • Conjugation:
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  • Gene Expression
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  • COA
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions & microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/if_selected.jpg
Figure 2 IF staining of human cell line CACO-2
Figure 2 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/1026_E7_1_red_green.jpg
Figure 3 IF staining of human cell line MCF7
Figure 3 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to microtubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43616/965_H10_1_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_B_8_5.jpg
Figure 5 Colon
Figure 5 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_9_3.jpg
Figure 6 Liver
Figure 6 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_8_4.jpg
Figure 7 Kidney
Figure 7 Kidney
(Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%
Proximal tubules (cell body)
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_7_5.jpg
Figure 8 Testis
Figure 8 Testis
(Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_6_6.jpg
Figure 9 Skin
Figure 9 Skin
(Epidermal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_B_4_8.jpg
Figure 10 Lymph node
Figure 10 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61700/138414_A_8_8.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (HaCaT, OE19, SuSa)
Figure 11 RNA cell line category: Cell line enhanced (HaCaT, OE19, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000158769-F11R

Specifications

  • Host Species
  • Humanized
  • Derivation
  • Humanized
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
  • Storage
  • Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.

Target

  • Alternative Names
  • F11R; F11 receptor; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; junctional adhesion molecule A; platelet F11 receptor; platelet adhesion molecule 1; junctional adhesion molecule 1

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT Product Name Application Type
NAB-914-VHH Recombinant Anti-Human F11R VHH Single Domain Antibody ICC, FC, WB, FUNC Llama VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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