Anti-Human FGFR1 Recombinant Antibody scFv Fragment (FR1-H7)
CAT#: TAB-052WM-S(P)
Antibody FR1-H7 binds FGFR-1(IIIb) and -1(IIIc) with strong affinities, but does not recognize any of the other FGFRs. Results from kinetic analysis indicated the antibody binds to FGFR-1b and -1c equally well. The KDs of the interactions were determined to be approximately 50 μM for both receptors. This product can be potentially used for antagonizing EGFR-1 or EGFR-4 as a treatment for obesity, diabetes, or a condition related thereto, and methods of reducing food intake.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_9_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AN3-CA, BJ hTERT+)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077782-FGFR1
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Specifications
- Host Species
- Human
- Derivation
- Phage-displayed human Fab library
- Type
- Human Antibody
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- FR1-H7
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Neutralization; Blocking
- Related Disease
- Obesity, diabetes
Target
- Alternative Names
- FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1
- Gene ID
- 2260
- UniProt ID
- P11362
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-052WM | Anti-Human FGFR1 Recombinant Antibody (FR1-H7) | ELISA, Neut | Human Antibody |
| TAB-054WM | Human Anti-FGFR1 Recombinant Antibody (TAB-054WM) | ELISA | Human IgG |
| TAB-054WM-S(P) | Human Anti-FGFR1 Recombinant Antibody; scFv Fragment (TAB-054WM-S(P)) | ELISA | Human scFv |
| TAB-052WM-F(E) | Anti-Human FGFR1 Recombinant Antibody Fab Fragment (FR1-H7) | ELISA, BL, Neut | Human Antibody |
| TAB-054WM-F(E) | Human Anti-FGFR1 Recombinant Antibody; Fab Fragment (TAB-054WM-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-053WM | Mouse Anti-FGFR1 Recombinant Antibody (TAB-053WM) | WB, FC | Mouse IgG |
| TAB-053WM-S(P) | Mouse Anti-FGFR1 Recombinant Antibody; scFv Fragment (TAB-053WM-S(P)) | WB | Mouse scFv |
| TAB-053WM-F(E) | Mouse Anti-FGFR1 Recombinant Antibody; Fab Fragment (TAB-053WM-F(E)) | WB | Mouse Fab |
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| CAT | Product Name | Application | Type |
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| HPAB-0118-FY-F(E) | Human Anti-FGFR1 Recombinant Antibody; Fab Fragment (HPAB-0118-FY-F(E)) | ELISA | Human Fab |
| HPAB-0485LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A7/C6/D9); Fab Fragment | ELISA | Human Fab |
| HPAB-0486LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A9/H10); Fab Fragment | ELISA | Human Fab |
| HPAB-0487LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-B1/E12); Fab Fragment | ELISA | Human Fab |
| HPAB-3044LY-F(E) | Mouse Anti-FGFR1 Recombinant Antibody; Fab Fragment (HPAB-3044LY-F(E)) | ELISA | Mouse Fab |
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| HPAB-0485LY-S(P) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A7/C6/D9); scFv Fragment | ELISA | Human scFv |
| HPAB-0486LY-S(P) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A9/H10); scFv Fragment | ELISA | Human scFv |
| HPAB-0487LY-S(P) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-B1/E12); scFv Fragment | ELISA | Human scFv |
| HPAB-0488LY-S(P) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-C1); scFv Fragment | ELISA | Human scFv |
| HPAB-0489LY-S(P) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-C7); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY35 | Human Anti-FGFR1 (clone FR1-H7) scFv-Fc Chimera | ELISA, Neut | Human IgG1, scFv-Fc |
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