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    For Research Use Only. Not For Clinical Use.


    Creative Biolabs offers a wide array of high-quality anti-FGFR1 recombinant antibodies, precisely engineered for diverse immunological research. These antibodies are designed for exceptional precision and specificity, allowing researchers to study FGFR1 in various biological processes accurately.

    FGFR1: A Potential Target for Cancer Therapy

    FGFR1 (fibroblast growth factor receptor type 1), a receptor tyrosine kinase essential for normal development and physiology, has been implicated in oncogenesis when aberrantly activated. Amplification of FGFR1 is particularly prevalent in pulmonary squamous cell carcinomas, and preclinical studies have shown its potential as a therapeutic target. Given its high involvement in cancer development, targeting FGFR1 is expected to be an effective approach to cancer treatment.

    Alternative Names

    Fibroblast growth factor receptor 1; FGFR1_HUMAN; heparin-binding growth factor receptor 1; BFGFR; C-FGR; CD331; CEK; FLG; FMS-like gene; FLT2; hydroxyaryl-protein kinase; FMS-like tyrosine kinase 2; N-SAM tyrosine kinase; protein-tyrosine kinase; tyrosyl protein kinase; KAL2.

    Background

    The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
    Protein class

    Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, RAS pathway related proteins, Transporters

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Leydig cells, Fibroblasts, Oligodendrocyte precursor cells)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (AN3-CA, BJ hTERT+)

    Interaction

    Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF5, FGF6, FGF8, FGF10, FGF19, FGF21, FGF22 and FGF23 (in vitro) (PubMed:1697263, PubMed:1722683, PubMed:8663044, PubMed:9655399, PubMed:12181353, PubMed:16597617, PubMed:17623664). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19, FGF21 and FGF23 (PubMed:19966287). Interacts (phosphorylated on Tyr-766) with PLCG1 (via SH2 domains) (PubMed:1656221, PubMed:1379697, PubMed:21765395). Interacts with FRS2 (PubMed:21765395). Interacts with RPS6KA1 (PubMed:15117958). Interacts (via C-terminus) with NEDD4 (via WW3 domain) (PubMed:21765395). Interacts with KL (By similarity). Interacts with SHB (via SH2 domain) (PubMed:12181353). Interacts with GRB10 (PubMed:10454568). Interacts with ANOS1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2 (PubMed:19696444). Interacts with SOX2 and SOX3. Interacts with FLRT1, FLRT2 and FLRT3 (By similarity). Found in a ternary complex with FGF1 and ITGAV:ITGB3 (PubMed:20422052, PubMed:18441324).

    Molecular function

    Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase

    More Types Infomation

    Anti-FGFR1 Recombinant Antibody Products

    Creative Biolabs provides a wide range of recombinant antibodies that target FGFR1 and are specifically designed for reliable identification and neutralization. With a number of formats available, these antibodies exhibit outstanding specificity and affinity, making them useful for a wide range of applications. Whether for study or therapeutic development, Creative Biolabs' anti-FGFR1 antibodies are critical instruments for expanding knowledge in immunology, cancer, and other related areas.

    Table 1. Featured anti-FGFR1 recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    TAB-283CL Human Anti-FGFR1 Recombinant Antibody Human Human IgG WB, IHC
    TAB-052WM Anti-Human FGFR1 Recombinant Antibody (FR1-H7) Human Human Antibody ELISA, Neut
    HPAB-0701-FY Mouse Anti-FGFR1 Recombinant Antibody (clone Ab21) Human, Mouse Mouse IgG1 ELISA
    HPAB-0118-FY Human Anti-FGFR1 Recombinant Antibody Human, Monkey Human IgG1 ELISA
    HPAB-3044LY Mouse Anti-FGFR1 Recombinant Antibody Human Mouse IgG ELISA

    Creative Quality Control

    Creative Biolabs specializes in delivering high-quality anti-FGFR1 recombinant antibodies designed specifically for research applications. With cutting-edge amenities along with robust quality control strategies, we ensure that our products have exceptional specificity and binding affinity. Our team of experienced biotechnology professionals is dedicated to enhancing our methods and providing reliable solutions to support your scientific research and projects.

    Fig.1 ELISA analysis. (Creative Biolabs Original)Fig.1 ELISA analysis of anti-FGFR1 antibody
    (Cat# TAB-052WM, Creative Biolabs).

    Fig.2 WB analysis. (Creative Biolabs Original)Fig.2 WB analysis of anti-FGFR1 antibody
    (Cat# TAB-052WM, Creative Biolabs).

    Customer Reviews

    Excellent
    Sh***y
    Mouse Anti-FGFR1 Recombinant Antibody (clone 20H8) (MOB-1638z)
    I've tried anti-FGFR1 antibodies from several other vendors, but Creative Biolabs' products have consistently outperformed them in terms of both quality and cost-effectiveness. Their antibodies are highly sensitive and specific, allowing me to detect even low levels of FGFR1 in my samples. Additionally, their pricing is competitive, making them a great value for the money. I've been a loyal customer of Creative Biolabs for years, and I would highly recommend their anti-FGFR1 antibodies to anyone looking for a reliable and affordable option.
    16/Apr/2022
    Excellent
    Sc***s
    Human Anti-FGFR1 Recombinant Antibody (clone SEEDbody A08) (HPAB-N0346-YC)
    Not only are Creative Biolabs' anti-FGFR1 antibodies top-notch, but their technical support is also exceptional. When I had a question about optimizing my experimental protocol, their team was quick to respond and provided me with valuable advice. They obviously understand their goods and are always prepared to go above and above to assist researchers achieve. I'm quite pleased with my experience with Creative Biolabs.
    27/Sep/2023
    Excellent
    We***r
    Human Anti-FGFR1 Recombinant Antibody (HPAB-0118-FY) (HPAB-0118-FY)
    Creative Biolabs' anti-FGFR1 recombinant antibodies routinely outperformed my expectations in the area of efficacy and reliability. The high specificity and affinity of the antibody have enabled me to obtain reproducible and accurate results in my experiments. I have complete confidence in the quality and consistency of Creative Biolabs' products.
    11/Mar/2024

    Anti-FGFR1 Recombinant Antibody Production

    Creative Biolabs employs a novel recombinant antibody production technology particularly tailored for the synthesis of anti-FGFR1 antibodies. Our cutting-edge genetic engineering technologies enable the flexible synthesis of high-quality antibodies, ensuring a constant and reliable supply to support your various research purposes.

    Featured Anti-FGFR1 Recombinant Antibody Production Platforms Fig.3 Milligram-scale. (Creative Biolabs Original)
    Fig.3 Milligram-scale anti-FGFR1 recombinant antibody production.

    Fig.4 Gram-scale. (Creative Biolabs Original)Fig.4 Gram-scale anti-FGFR1 recombinant antibody production.

    Anti-FGFR1 Recombinant Antibody Modalities

    Creative Biolabs provides a comprehensive selection of high-quality anti-FGFR1 recombinant antibodies in a variety of forms to address the unique demands of scientists worldwide.

    Fig.5 FGFR1 antibody production and modalities. (Creative Biolabs Original)Fig.5 Full-length anti-FGFR1 recombinant antibody production and modalities.

    FGFR1-Targeted Drug Information

    Public Drug Information Targeting FGFR1

    Table 2. Public drug targeting FGFR1.

    Company Research Phase Classification Condition
    RemeGen (Originator) Phase III Fc Fusion Proteins
    Polypeptides, from 41 AA     		Diabetic macular edema
    Retinopathy, diabetic
    Wet macular degeneration (exudative)
    Merck & Co
    Merck & Co. (Merck & Co)
    NGM Biopharmaceuticals (Originator)     		Phase II Agonist Antibodies
    Humanized Monoclonal Antibodies     		Diabetes type 2
    Non-alcoholic steatohepatitis (NASH)
    Obesity
    Amgen (Originator)
    Five Prime Therapeutics (Amgen)
    GlaxoSmithKline (GSK)
    GSK
    Human Genome Sciences (GSK)     		Phase II Cancer Immunotherapy
    Fc Fusion Proteins
    Polypeptides, from 41 AA     		Cancer
    Cancer, breast
    Cancer, endometrium
    Cancer, lung (non-small cell) (NSCLC) (squamous cell carcinoma)
    Cancer, ovary
    Cancer, solid tumor
    Mesothelioma, malignant
    Merck & Co (Originator)
    Thomas Jefferson University (Originator)     		Phase II Acidic Fibroblast Growth Factor (aFGF; FGF-1)
    Polypeptides, from 41 AA
    Recombinant proteins     		Lesion, skin
    Restenosis, arterial
    Phage Pharmaceuticals (Originator) Phase I Acidic Fibroblast Growth Factor (aFGF; FGF-1)
    Polypeptides, from 41 AA
    Recombinant proteins     		Ear Disorders
    Ulcer foot, diabetic
    Chugai Pharmaceutical
    Genentech (Originator)     		Discontinued Bispecific Antibodies
    Monoclonal Antibodies     		Diabetes type 2
    Insulin resistance
    Non-alcoholic steatohepatitis (NASH)
    Novo Nordisk (Originator) Preclinical Fibroblast Growth Factors (FGF)
    Polypeptides, from 41 AA
    Recombinant proteins     		Non-alcoholic fatty liver disease (NAFLD)
    Fifth Peoples' Hospital of Shanghai (Originator) Preclinical MicroRNA
    Single-stranded oligoribonucleotide (RNA)     		Cancer, lung (non-small cell) (NSCLC)
    EMD Serono (Originator)
    Ligand (Originator)
    Merck KGaA (Originator)     		Preclinical Cancer Immunotherapy
    Human Monoclonal Antibodies     		Cancer, lung
    AstraZeneca (Originator) Preclinical Bispecific Antibodies
    Human Monoclonal Antibodies     		Valvular heart disorders

    (Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

    Creative Biolabs is a leading provider of high-quality anti-FGFR1 recombinant antibodies. Our products are designed for precision and specificity, making them appropriate for a variety of research applications. Contact our scientific team to discuss your specific needs and explore how our anti-FGFR1 antibodies can contribute to your research goals.

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