Mouse Anti-HBEGF Recombinant Antibody (clone HB-20)
CAT#: HPAB-0092-LS
The antibody is used for the treatment of pancreatic cancer, liver cancer, esophageal cancer, melanomacancpreferabal.
Published Data
Gene Expression
ELISA
Figure 1 The binding activity of antibodies HA-20, HB-20, and HC-15 to active-form HB-EGF;
FC
Figure 2 Histograms that show the binding activity of antibodies HA-20, HB-20, and HC-15 to proHB-EGF.
Inhib
Figure 3 The inhibition of binding of HB-EGF to EGFR by antibodies HA-20, HB-20, and HC-15.
Inhib
Figure 4 Compares the inhibition of the growth of EGFR_Ba/F3 cells by antibodies HA-20, HB-20, and HC-15.
FuncS
Figure 5 The inhibition of growth of the ovarian cancer cell line RMG-1 by the antibodies HA-20, HB-20, and HC-15 in a medium containing 8% FCS;
FuncS
Figure 6 The internalization-mediated activity of the HA-20, HB-20, and HC-15 antibodies to induce cell death in SKOV-3 cells (original cell line) and HB-EGF_SKOV3 cells (high HB-EGF-expressing SKOV-3 cells).
FC
Figure 7 The binding activity of the HA-20, HB-20, and HC-15 antibodies for the HB-EGF on ES-2 cells.
FuncS
Figure 8 The internalization-mediated cell death inducing activity of HA-20, HB-20, and HC-15, on ES-2 ovarian cancer cells.
FC
Figure 9 The FACS analysis of the binding activity exhibited by various anti-HB-EGF antibodies for HB-EGF overexpressed in Ba/F3 cells; the fluorescence intensity is expressed on the vertical axis as the G-mean value.
ADCC
Figure 10 The ADCC activity exhibited by various anti-HB-EGF antibodies on HB-EGF_Ba/F3 cells (upper) and the CDC activity exhibited by various anti-HB-EGF antibodies on HB-EGF_Ba/F3 cells (lower); the vertical axis shows the amount of chromium released from the cells due to ADCC-mediated or CDC-mediated cytotoxicity.
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Normal Tissue
Figure 1 IHC staining of human heart muscle
Immunohistochemical staining of human heart muscle shows strong cytoplasmic positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53243/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53243/120132_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53243/120132_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53243/120132_A_9_5.jpg
Normal Tissue
Figure 5 Heart muscle
Cardiomyocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53243/120132_B_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HBF TERT88, JURKAT, TIME, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000113070-HBEGF
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Specifications
- Immunogen
- HBEGF
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human HBEGF
- Species Reactivity
- Human
- Clone
- HB-20
- Applications
- Inhib, FC, ELISA, ADCC, FuncS
- Related Disease
- Pancreatic cancer, liver cancer, esophageal cancer, melanoma
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Inhibition, Flow Cytometry, Enzyme-linked Immunosorbent Assay, ADCC, Functional Assay.
Target
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Related Diseases
Bladder Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Name
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-340CL | Anti-Human HBEGF Recombinant Antibody (KHK2866) | FuncS | Antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-895CQ | Mouse Anti-HBEGF Recombinant Antibody (clone MM0324-3R44) | WB, Neut | Mouse IgG2 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0119-YC-S(P) | Mouse Anti-HBEGF Recombinant Antibody (clone 2F7); scFv Fragment | ELISA, FC, WB, Neut | Mouse scFv |
| HPAB-0593-CN-S(P) | Mouse Anti-HBEGF Recombinant Antibody; scFv Fragment (HPAB-0593-CN-S(P)) | WB, ELISA, FC, Neut | Mouse scFv |
| HPAB-0594-CN-S(P) | Human Anti-HBEGF Recombinant Antibody; scFv Fragment (HPAB-0594-CN-S(P)) | WB, ELISA, FC, Neut | Humanized scFv |
| HPAB-0091-LS-S(P) | Mouse Anti-HBEGF Recombinant Antibody (clone HA-20); scFv Fragment | Inhib, FC, ELISA | Mouse scFv |
| HPAB-0092-LS-S(P) | Mouse Anti-HBEGF Recombinant Antibody (clone HB-20); scFv Fragment | Inhib, FC, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0119-YC-F(E) | Mouse Anti-HBEGF Recombinant Antibody (clone 2F7); Fab Fragment | ELISA, FC, WB, Neut | Mouse Fab |
| HPAB-0593-CN-F(E) | Human Anti-HBEGF Recombinant Antibody; Fab Fragment (HPAB-0593-CN-F(E)) | WB, ELISA, FC, Neut | Human Fab |
| HPAB-0594-CN-F(E) | Human Anti-HBEGF Recombinant Antibody; Fab Fragment (HPAB-0594-CN-F(E)) | WB, ELISA, FC, Neut | Humanized Fab |
| HPAB-0091-LS-F(E) | Mouse Anti-HBEGF Recombinant Antibody (clone HA-20); Fab Fragment | Inhib, FC, ELISA | Mouse Fab |
| HPAB-0092-LS-F(E) | Mouse Anti-HBEGF Recombinant Antibody (clone HB-20); Fab Fragment | Inhib, FC, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC629 | Recombinant Anti-HBEGF Vesicular Antibody, EV Displayed (VS-0425-YC629) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY3071 | Anti-HBEGF Immunohistochemistry Kit | IHC |
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