Anti-Human HBEGF Recombinant Antibody (KHK2866) (CAT#: TAB-340CL)
Recombinant Humanized monoclonal antibody expressed in CHO binding to Human HBEGF. This is a monoclonal antibody targeting anti-heparin-binding EGF-like growth factor (HB-EGF), was being developed for the treatment of dvanced solid tumors and ovarian cancer.
Specific Inquiry
FuncS
Figure 1 Mean serum KHK2866 concentration-time profiles during cycle 1.
Arrows indicate time of weekly dose administration. Error bars indicate standard deviation of the mean. Note: post-dose determination of serum KHK2866 was not performed following the second and third dose except for trough values immediately prior to dose administration indicated at day 14 and 21 time points.
Sarantopoulos, J., Mita, M. M., Birrer, M. J., Cranmer, L. D., Campos, L. T., Zhang, X., ... & Camacho, L. H. (2016). Phase 1 study of monotherapy with khk2866, an anti-heparin-binding epidermal growth factor-like growth factor monoclonal antibody, in patients with advanced cancer. Targeted oncology, 11(3), 317-327.
Specifications
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- FuncS
- Related Disease
- Solid Tumors
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Applications
- Application Notes
- This antibody has been reported for use in Function Assay.
Target
- Alternative Names
- HBEGF; heparin-binding EGF-like growth factor; DTR; DTS; DTSF; HEGFL; proheparin-binding EGF-like growth factor; heparin-binding epidermal growth factor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (hepari
- Gene ID
- 1839
- UniProt ID
- Q99075
Related Resources
Bladder Cancer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "HBEGF"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1493z | Mouse Anti-HBEGF Recombinant Antibody (clone 25C6) | WB, IHC, Neut | Mouse IgG1 |
| MOB-2309MZ | Recombinant Mouse Anti-Human HBEGF Antibody (clone 5H20), Biotin-Conjugated | ICC/IF, IP, WB | Mouse antibody |
| HPAB-0119-YC | Mouse Anti-HBEGF Recombinant Antibody (clone 2F7) | ELISA, FC, WB, Neut | Mouse IgG |
| HPAB-0593-CN | Human Anti-HBEGF Recombinant Antibody (HPAB-0593-CN) | WB, ELISA, FC, Neut | Chimeric (mouse/human) IgG1 |
| VS3-FY656 | Recombinant Rabbit Anti-HBEGF Antibody (clone R08-9C2) | WB | Rabbit IgG |
Mouse Antibody
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-015CT | Anti-Human HB-EGF Recombinant Antibody | ELISA, Inhibition, FC | Humanized antibody |
| TAB-015CT-S(P) | Anti-Human HB-EGF Recombinant Antibody scFv Fragment | ELISA, Inhibition, FC | Humanized antibody |
| TAB-015CT-F(E) | Anti-Human HB-EGF Recombinant Antibody Fab Fragment | ELISA, Inhibition, FC | Humanized antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-895CQ | Mouse Anti-HBEGF Recombinant Antibody (clone MM0324-3R44) | WB, Neut | Mouse IgG2 |
| NEUT-896CQ | Mouse Anti-HBEGF Recombinant Antibody (clone CBL069) | WB, Neut | Mouse IgG2 |
| NEUT-897CQ | Mouse Anti-HBEGF Recombinant Antibody (clone CBL271) | WB, Neut, ELISA | Mouse IgG2a |
| NEUT-898CQ | Mouse Anti-HBEGF Recombinant Antibody (clone CBL374) | Neut, WB | Mouse IgG2a |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0119-YC-S(P) | Mouse Anti-HBEGF Recombinant Antibody (clone 2F7); scFv Fragment | ELISA, FC, WB, Neut | Mouse scFv |
| HPAB-0593-CN-S(P) | Mouse Anti-HBEGF Recombinant Antibody; scFv Fragment (HPAB-0593-CN-S(P)) | WB, ELISA, FC, Neut | Mouse scFv |
| HPAB-0594-CN-S(P) | Human Anti-HBEGF Recombinant Antibody; scFv Fragment (HPAB-0594-CN-S(P)) | WB, ELISA, FC, Neut | Humanized scFv |
| HPAB-0091-LS-S(P) | Mouse Anti-HBEGF Recombinant Antibody (clone HA-20); scFv Fragment | Inhib, FC, ELISA | Mouse scFv |
| HPAB-0092-LS-S(P) | Mouse Anti-HBEGF Recombinant Antibody (clone HB-20); scFv Fragment | Inhib, FC, ELISA | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0593-CN-F(E) | Human Anti-HBEGF Recombinant Antibody; Fab Fragment (HPAB-0593-CN-F(E)) | WB, ELISA, FC, Neut | Human Fab |
| HPAB-0594-CN-F(E) | Human Anti-HBEGF Recombinant Antibody; Fab Fragment (HPAB-0594-CN-F(E)) | WB, ELISA, FC, Neut | Humanized Fab |
| HPAB-0091-LS-F(E) | Mouse Anti-HBEGF Recombinant Antibody (clone HA-20); Fab Fragment | Inhib, FC, ELISA | Mouse Fab |
| HPAB-0092-LS-F(E) | Mouse Anti-HBEGF Recombinant Antibody (clone HB-20); Fab Fragment | Inhib, FC, ELISA | Mouse Fab |
| HPAB-0094-LS-F(E) | Mouse Anti-HBEGF Recombinant Antibody (clone 8d71c81e9); Fab Fragment | ELISA, Inhib, WB, FC | Mouse Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0387-YC | Recombinant Camelid Anti-HBEGF Single Domain Antibody (M/YC-25) | ELISA | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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