Recombinant Human Anti-HCV Antibody (HC33.4) (CAT#: PABX-071)

Anti-HCV antibody is a Human antibody of IgG class that binds to an HCV.


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Figure 1 Binding properties of broadly neutralizing HMAbs.

Figure 1 Binding properties of broadly neutralizing HMAbs.

(A) Antibody binding to wt or HVR1 recombinant E2 determined by ELISA. Recombinant H77C E2 cell lysate was captured on GNA-precoated wells. Bound proteins were incubated with each test HMAb at 1 g/ml (x axis), and bound antibody was detected. with antihuman antibody. The y axis shows the mean optical density values for triplicate wells (means from three experiments standard deviations [SD]). (B)Tabulation of difference in binding between HVR1 and wt E2 with calculated P values.

Keck, Z. Y., Girard-Blanc, C., Wang, W., Lau, P., Zuiani, A., Rey, F. A., ... & Foung, S. K. (2016). Antibody response to hypervariable region 1 interferes with broadly neutralizing antibodies to hepatitis C virus. Journal of virology, 90(6), 3112-3122.

Figure 2 SNAPR-values across E1E2 determined using only subtype 1a HCVpp neutralized by HC33.4 or AR4A.

Figure 2 SNAPR-values across E1E2 determined using only subtype 1a HCVpp neutralized by HC33.4 or AR4A.

The 8 positions with lowest SNAPR-values for HC33.4 and AR4A are in bold print. Previously defined HC33.4 and AR4A binding epitopes are indicated (blue and pink), as is hypervariable region 1 (HVR1) (gray).

El-Diwany, R., Cohen, V. J., Mankowski, M. C., Wasilewski, L. N., Brady, J. K., Snider, A. E., ... & Bailey, J. R. (2017). Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1. PLoS pathogens, 13(2), e1006235.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG
  • Specificity
  • Tested positive against native Hepatitis C virus HCV
  • Species Reactivity
  • Hepatitis C virus
  • Clone
  • HC33. 4
  • Applications
  • WB 1:1000-1:5000
    ELISA 1:10000-1:20000
    Neut (assay dependent)
    FuncS (assay dependent)
    IHC(P) 1:200-1:2000

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • Assay-depended

Target

  • Alternative Names
  • Hepatitis C virus; HCV; HVC; Flaviviridae

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone HC33. 4"

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Single-domain Antibody

CAT Product Name Application Type
NABG-079 Recombinant Anti-HCV VHH Single Domain Antibody ELISA, IHC, FC, FuncS Llama VHH

Mouse Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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