Anti-HCV antibody is a Human antibody of IgG class that binds to an HCV.
Figure 1 Binding properties of broadly neutralizing HMAbs.
(A) Antibody binding to wt or HVR1 recombinant E2 determined by ELISA. Recombinant H77C E2 cell lysate was captured on GNA-precoated wells. Bound proteins were incubated with each test HMAb at 1 g/ml (x axis), and bound antibody was detected. with antihuman antibody. The y axis shows the mean optical density values for triplicate wells (means from three experiments standard deviations [SD]). (B)Tabulation of difference in binding between HVR1 and wt E2 with calculated P values.
Keck, Z. Y., Girard-Blanc, C., Wang, W., Lau, P., Zuiani, A., Rey, F. A., ... & Foung, S. K. (2016). Antibody response to hypervariable region 1 interferes with broadly neutralizing antibodies to hepatitis C virus. Journal of virology, 90(6), 3112-3122.
Figure 2 SNAPR-values across E1E2 determined using only subtype 1a HCVpp neutralized by HC33.4 or AR4A.
The 8 positions with lowest SNAPR-values for HC33.4 and AR4A are in bold print. Previously defined HC33.4 and AR4A binding epitopes are indicated (blue and pink), as is hypervariable region 1 (HVR1) (gray).
El-Diwany, R., Cohen, V. J., Mankowski, M. C., Wasilewski, L. N., Brady, J. K., Snider, A. E., ... & Bailey, J. R. (2017). Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1. PLoS pathogens, 13(2), e1006235.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-444 | Recombinant Anti-HCV Antibody | ELISA, WB, IF, FuncS | IgG |
PABZ-057 | Recombinant Mouse Anti-HCV Antibody (19D9D6) | ELISA | IgG |
HPAB-0043LY | Recombinant Mouse Anti-HCV Antibody (PA-29) | WB | |
HPAB-0802-FY | Recombinant Anti-HCV Antibody (AOT3) | E | |
HPAB-0803-FY | Recombinant Anti-HCV Antibody (C11-3) | E |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-444-S(P) | Recombinant Anti-HCV Antibody scFv Fragment | WB, IHC, FuncS | scFv |
HPAB-0232-FY-S(P) | Recombinant Human Anti-HCV Antibody scFv Fragment (TRN1007) | WB, F, N | Human scFv |
FAMAB-0024WJ-S(P) | Human Anti-HCV Recombinant Antibody (clone B12.F8); scFv Fragment | ELISA, IF, IHC | Human scFv |
FAMAB-0025WJ-S(P) | Human Anti-HCV Recombinant Antibody (clone CM3.B6); scFv Fragment | ELISA, IF, IHC | Human scFv |
FAMAB-0026WJ-S(P) | Human Anti-HCV Recombinant Antibody (clone E6.D10); scFv Fragment | ELISA, IF, IHC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NABG-079 | Recombinant Anti-HCV VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-444-F(E) | Recombinant Human Anti-HCV Antibody Fab Fragment | ELISA, WB, IP, FuncS | Fab |
PFBZ-057 | Recombinant Mouse Anti-HCV Antibody Fab Fragment (19D9D6) | ELISA | IgG |
HPAB-1118LY-F(E) | Humanized Anti-HCV Antibody Fab Fragment (CBL021) | ELISA, FC | |
HPAB-0232-FY-F(E) | Recombinant Human Anti-HCV Antibody Fab Fragment (TRN1007) | WB, F, N | Human Fab |
HPAB-0233-FY-F(E) | Recombinant Human Anti-HCV Antibody Fab Fragment (TRN1009) | WB, E, N | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-344CL | Human Anti-HCV Recombinant Antibody (TAB-344CL) | FuncS | Human IgG |
PABX-079 | Recombinant Human Anti-Hepatitis C virus Antibody (AP33) | WB, ELISA, FuncS | IgG |
PABX-071-F (E) | Recombinant Human Anti-HCV Antibody Fab Fragment (HC33.4) | WB, ELISA, Neut, FuncS | Fab |
PABX-079-F (E) | Recombinant Human Anti-Hepatitis C virus Antibody Fab Fragment (AP33) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-071-S (P) | Recombinant Human Anti-HCV Antibody scFv Fragment (HC33.4) | WB, ELISA, Neut, FuncS | scFv |
PABX-079-S (P) | Recombinant Human Anti-Hepatitis C virus Antibody scFv Fragment (AP33) | WB, ELISA, FuncS | scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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