Recombinant Human Anti-HCV Antibody scFv Fragment (HC33.4)
CAT#: PABX-071-S (P)
Anti-HCV antibody (HC33.4) is a human of scFv class that binds to an HCV.
Published Data
-1.png)
Figure 1 Binding properties of broadly neutralizing HMAbs.
(A) Antibody binding to wt or HVR1 recombinant E2 determined by ELISA. Recombinant H77C E2 cell lysate was captured on GNA-precoated wells. Bound proteins were incubated with each test HMAb at 1 g/ml (x axis), and bound antibody was detected. with antihuman antibody. The y axis shows the mean optical density values for triplicate wells (means from three experiments standard deviations [SD]). (B)Tabulation of difference in binding between HVR1 and wt E2 with calculated P values.
Keck, Z. Y., Girard-Blanc, C., Wang, W., Lau, P., Zuiani, A., Rey, F. A., ... & Foung, S. K. (2016). Antibody response to hypervariable region 1 interferes with broadly neutralizing antibodies to hepatitis C virus. Journal of virology, 90(6), 3112-3122.
-2.png)
Figure 2 SNAPR-values across E1E2 determined using only subtype 1a HCVpp neutralized by HC33.4 or AR4A.
The 8 positions with lowest SNAPR-values for HC33.4 and AR4A are in bold print. Previously defined HC33.4 and AR4A binding epitopes are indicated (blue and pink), as is hypervariable region 1 (HVR1) (gray).
El-Diwany, R., Cohen, V. J., Mankowski, M. C., Wasilewski, L. N., Brady, J. K., Snider, A. E., ... & Bailey, J. R. (2017). Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1. PLoS pathogens, 13(2), e1006235.
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- scFv
- Specificity
- Tested positive against native NGF
- Species Reactivity
- Hepatitis C virus
- Clone
- HC33. 4
- Applications
- WB 1:1000-1:5000
ELISA 1:10000-1:20000
Neut (assay dependent)
FuncS (assay dependent)
IHC(P) 1:200-1:2000
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- Hepatitis C virus; HCV; HVC; Flaviviridae
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-444 | Recombinant Human Anti-HCV Antibody | IF, Neut, FuncS | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-344CL | Human Anti-HCV Recombinant Antibody (TAB-344CL) | FuncS | Human IgG |
| PABX-071 | Recombinant Human Anti-HCV Antibody (HC33.4) | WB, ELISA, Neut, FuncS | IgG |
| PABX-079 | Recombinant Human Anti-Hepatitis C virus Antibody (AP33) | WB, ELISA, FuncS | IgG |
| PABX-071-F (E) | Recombinant Human Anti-HCV Antibody Fab Fragment (HC33.4) | WB, ELISA, Neut, FuncS | Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-079-S (P) | Recombinant Human Anti-Hepatitis C virus Antibody scFv Fragment (AP33) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
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| HPAB-1119LY-F(E) | Humanized Anti-HCV Antibody Fab Fragment (CBL022) | ELISA, FC | |
| HPAB-1120LY-F(E) | Humanized Anti-HCV Antibody Fab Fragment (CBL023) | ELISA, FC | |
| HPAB-1121LY-F(E) | Humanized Anti-HCV Antibody Fab Fragment (CBL024) | ELISA, FC | |
| HPAB-1178-FY-S(P) | Human Anti-HCV Recombinant Antibody scFv Fragment (HPAB-1178-FY-S(P)) | ELISA | Human scFv |
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