Recombinant Human Anti-HCV Antibody Fab Fragment (HC33.4) (CAT#: PABX-071-F (E))
Anti-HCV antibody is a Human of Fab class that binds to an HCV.
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-1.png)
Figure 1 Binding properties of broadly neutralizing HMAbs.
(A) Antibody binding to wt or HVR1 recombinant E2 determined by ELISA. Recombinant H77C E2 cell lysate was captured on GNA-precoated wells. Bound proteins were incubated with each test HMAb at 1 g/ml (x axis), and bound antibody was detected. with antihuman antibody. The y axis shows the mean optical density values for triplicate wells (means from three experiments standard deviations [SD]). (B)Tabulation of difference in binding between HVR1 and wt E2 with calculated P values.
Keck, Z. Y., Girard-Blanc, C., Wang, W., Lau, P., Zuiani, A., Rey, F. A., ... & Foung, S. K. (2016). Antibody response to hypervariable region 1 interferes with broadly neutralizing antibodies to hepatitis C virus. Journal of virology, 90(6), 3112-3122.
-2.png)
Figure 2 SNAPR-values across E1E2 determined using only subtype 1a HCVpp neutralized by HC33.4 or AR4A.
The 8 positions with lowest SNAPR-values for HC33.4 and AR4A are in bold print. Previously defined HC33.4 and AR4A binding epitopes are indicated (blue and pink), as is hypervariable region 1 (HVR1) (gray).
El-Diwany, R., Cohen, V. J., Mankowski, M. C., Wasilewski, L. N., Brady, J. K., Snider, A. E., ... & Bailey, J. R. (2017). Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1. PLoS pathogens, 13(2), e1006235.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- Fab
- Specificity
- Tested positive against native Hepatitis C virus HCV
- Species Reactivity
- Hepatitis C virus
- Clone
- HC33. 4
- Applications
- WB 1:1000-1:5000
ELISA 1:10000-1:20000
Neut (assay dependent)
FuncS (assay dependent)
IHC(P) 1:200-1:2000
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- Hepatitis C virus; HCV; HVC; Flaviviridae
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Single Domain Antibody Products
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-079 | Recombinant Anti-HCV VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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