Recombinant Human Anti-HCV E2 Antibody (HCV1) (CAT#: PABL-500)
Recombinant Human Antibody (HCV1) is capable of binding to HCV E2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HCV E2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HCV E2 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. Human mAb HCV1 has broad neutralizing activity against HCV isolates from at least four major genotypes and protects in the chimpanzee model from primary HCV challenge. The antibody targets a conserved antigenic site (residues 412-423) on the virus E2 envelope glycoprotein.
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Figure 1 Blocking analysis of HuMAb HCV1 to E2 binding to CD81 LEL.
Varying concentration of HCV1 (blue diamonds) or irrelevant human antibody (red squares) were incubated with a constant concentration of E2660 and subsequently applied to CD81 LEL-coated to ELISA plates. Binding of E2660 to CD81 LEL was detected using an anti-(His)6 antibody and the percent inhibition as compared to no antibody plotted.
Morin, T. J., Broering, T. J., Leav, B. A., Blair, B. M., Rowley, K. J., Boucher, E. N., ... & Ludmerer, S. W. (2012). Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees. PLoS pathogens, 8(8), e1002895.
Specifications
- Immunogen
- HCV E2 envelope glycoprotein
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native HCV E2
- Species Reactivity
- HCV
- Clone
- HCV1
- Applications
- ELISA 1:1000-1:20000
Neut Assay-depended
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- E2; E2 (HCV); HCV E2
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Biparatopic Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-446 | Recombinant Human Anti-HCV E2 Antibody | FC, WB, FuncS | IgG |
| PABL-498 | Recombinant Human Anti-HCV E2 Antibody (C2) | Neut | IgG |
| PABL-499 | Recombinant Human Anti-HCV E2 Antibody (HC33.8) | Neut | IgG |
| PABL-501 | Recombinant Human Anti-HCV E2 Antibody (PABL-501) | ELISA, Neut | IgG |
| PABL-502 | Recombinant Human Anti-HCV E2 Antibody (mAb AP33) | Neut | IgG |
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