Recombinant Human Anti-HCV E2 Antibody (HCV1)
CAT#: PABL-500
Recombinant Human Antibody (HCV1) is capable of binding to HCV E2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HCV E2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HCV E2 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. Human mAb HCV1 has broad neutralizing activity against HCV isolates from at least four major genotypes and protects in the chimpanzee model from primary HCV challenge. The antibody targets a conserved antigenic site (residues 412-423) on the virus E2 envelope glycoprotein.
Published Data
Figure 1 Blocking analysis of HuMAb HCV1 to E2 binding to CD81 LEL.
Varying concentration of HCV1 (blue diamonds) or irrelevant human antibody (red squares) were incubated with a constant concentration of E2660 and subsequently applied to CD81 LEL-coated to ELISA plates. Binding of E2660 to CD81 LEL was detected using an anti-(His)6 antibody and the percent inhibition as compared to no antibody plotted.
Morin, T. J., Broering, T. J., Leav, B. A., Blair, B. M., Rowley, K. J., Boucher, E. N., ... & Ludmerer, S. W. (2012). Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees. PLoS pathogens, 8(8), e1002895.
❮
❯
Specifications
- Immunogen
- HCV E2 envelope glycoprotein
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native HCV E2
- Species Reactivity
- HCV
- Clone
- HCV1
- Applications
- ELISA 1:1000-1:20000
Neut Assay-depended
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- E2; E2 (HCV); HCV E2
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for PABL-500. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone HCV1"
- CAT
- Product Name
See other products for "HCV E2 protein"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-446 | Recombinant Human Anti-HCV E2 Antibody | FC, WB, FuncS | IgG |
| HPAB-0234-FY | Recombinant Human Anti-HCV E2 Antibody (HPAB-0234-FY) | E, N | Human IgG |
| HPAB-1125-CN | Recombinant Human Anti-HCV E2 Antibody (MRCT10.1) | WB, ELISA, IF | Human IgG1, κ |
| HPAB-1126-CN | Recombinant Human Anti-HCV E2 Antibody (MRCT10.V79) | WB, ELISA, IF | Human IgG1, κ |
| VS-0423-XY36 | Human Anti-HCV E2 Recombinant Antibody (clone 8D6) | ELISA, IHC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-492 | Mouse Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (PSBL-492) | ELISA, Neut | Mouse scFv |
| PSBL-493 | Recombinant Mouse Anti-HCV E2 Antibody scFv Fragment (AP33) | ELISA | scFv |
| PSBL-494 | Recombinant Human Anti-HCV E2 Antibody scFv Fragment (AR3C) | Neut | scFv |
| PSBL-495 | Recombinant Human Anti-HCV E2 Antibody scFv Fragment (C2) | Neut | scFv |
| PSBC-282 | Recombinant Human Anti-HCV E2 Antibody scFv Fragment (HC26AM) | ELISA, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-476LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-476LC) | ELISA, Inhib | Chimeric (mouse/human) IgG |
| MRO-476LC-S(P) | Mouse Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (MRO-476LC-S(P)) | ELISA | Mouse scFv |
| MRO-476LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-476LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-477LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-477LC) | ELISA | Humanized IgG1, κ |
| MRO-478LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-478LC) | ELISA | Humanized IgG1, κ |
| MRO-477LC-S(P) | Human Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (MRO-477LC-S(P)) | ELISA | Humanized scFv |
| MRO-478LC-S(P) | Human Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (MRO-478LC-S(P)) | ELISA | Humanized scFv |
| MRO-479LC-S(P) | Human Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (MRO-479LC-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-437LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (503) | ELISA | Human antibody |
| MRO-438LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (108) | ELISA | Human antibody |
| MRO-467LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (7F2) | ELISA | Human antibody |
| MRO-485LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (AB 68) | ELISA | Human antibody |
| MRO-488LC-S(P) | Anti-HCV E2 Recombinant Antibody scFv Fragment (CBH-4D) | ELISA, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1191LC | Anti-HCV E2 Recombinant Antibody (MRO-1191LC) | ELISA, Inhib | Mouse Antibody |
| MRO-1192LC | Anti-HCV E2 Recombinant Antibody (H6D3) | ELISA, Inhib, WB | Mouse Antibody |
| MRO-1191LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (MRO-1191LC-F(E)) | ELISA | Mouse Antibody |
| MRO-1192LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (H6D3) | ELISA | Mouse Antibody |
| MRO-1193LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (E3D8) | ELISA | Mouse Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC428 | PE-A*24:02/HCV E2 (EYVLLLFLL) MHC Tetramer | FCM | |
| MHC-LC429 | APC-A*24:02/HCV E2 (EYVLLLFLL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0065LC | Recombinant Mouse Anti-HCV E2 protein Antibody (JS-81) | ELISA | IgG1 |
| EPAF-1294LC | Recombinant Human Anti-HCV E2 protein Antibody (4c2) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0195CQ-F(E) | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (HPAB-0195CQ-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0196CQ-F(E) | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (HPAB-0196CQ-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0234-FY-F(E) | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (HPAB-0234-FY-F(E)) | E, N | Human Fab |
| HPAB-0084-WJ-F(E) | Mouse Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (HPAB-0084-WJ-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0085-WJ-F(E) | Mouse Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (HPAB-0085-WJ-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY82 | AbPlus™ Anti-HCV E2 Magnetic Beads (AP33) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC96 | Recombinant Anti-HCV E2 Protein (AA 412-423 x AA 434-446) Biparatopic Antibody, Tandem scFv (Clone mAb24 x Clone HC26AM) | ELISA, Neut | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-XY18 | Human Anti-HCV E2 Vaccinal Antibody (VS-0625-XY18) | ELISA, IF, Neut | Human IgG |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, Neut, FuncS
Application: ELISA, Inhib, FC
Application: WB, IHC, ELISA, FC
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, PD, Activ, PK, Stim
Application: FC, IHC, Cyt, FuncS
Application: WB, IHC-Fr, IHC-P, ICC, IF
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
