Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG3)
CAT#: MRO-025LC
This product is a recombinant human anti-HIV-1 monoclonal antibody. 4E10-IgG3 specifically binds to gp41 and can be potentially used in the treatment of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
Published Data
Neut
Figure 1. Inhibition of HIV-1 infection in primary macrophages. All three MAbs were IgG; 4E10 served as a positive control, and the nonneutralizing anti-HIV-1 Mab A32 was used as a negative control.
Zhu, Z., Qin, H. R., Chen, W., Zhao, Q., Shen, X., Schutte, R., ... & Fouda, G. G. (2011). Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of virology, 85(21), 11401-11408.
ELISA
Figure 2. Antibody-dependent cell-mediated viral inhibition (ADCVI) of 2F5 and 4E10 in comparison to b12. Supernatant was collected and assayed for p27 by ELISA to measure viral inhibition.
Hessell, A. J., Rakasz, E. G., Tehrani, D. M., Huber, M., Weisgrau, K. L., Landucci, G., ... & Burton, D. R. (2010). Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. Journal of virology, 84(3), 1302-1313.
ELISA
Figure 1 Binding of 2F5 and 4E10 to peptides 2030, 2031, and gp160. Serial twofold dilutions of peptides were coated overnight on ELISA plates before incubation with constant amounts of 4E10 or 2F5 (100 ng/ml).
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Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- HIV-1
- Clone
- 4E10-IgG3
- Applications
- ELISA
- Related Disease
- AIDS
Applications
- Application Notes
- The HIV-1 gp41 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 4E10-IgG3"
- CAT
- Product Name
See other products for "HIV-1 gp41"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-486-F(E) | Recombinant Human Anti-HIV-1 gp41 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| MRO-4045CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (MRO-4045CQ-F(E)) | ELISA | Human Fab |
| MRO-4046CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (MRO-4046CQ-F(E)) | Neut | Human Fab |
| MRO-4047CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (MRO-4047CQ-F(E)) | Neut | Human Fab |
| MRO-4048CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 126-50); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-185 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8062) | WB, ELISA, FuncS | Human IgG |
| PABL-186 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5) | WB, Neut, FuncS | Human IgG |
| PABL-187 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC176) | Neut, FuncS | Human IgG |
| PABL-188 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC315) | Neut, FuncS | Human IgG |
| PABL-189 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone m66) | Neut, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-185 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8062); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBL-186 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5); scFv Fragment | WB, Neut, FuncS | Human scFv |
| PSBL-187 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC176); scFv Fragment | Neut, FuncS | Human scFv |
| PSBL-188 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC315); scFv Fragment | Neut, FuncS | Human scFv |
| PSBL-189 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone m66); scFv Fragment | Neut, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-026LC | Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG1) | ELISA | Human antibody |
| MRO-040LC | Anti-HIV-1 gp41 Recombinant Antibody (M66.6) | ELISA | Human antibody |
| MRO-025LC-F(E) | Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (4E10-IgG3) | ELISA | Human antibody |
| MRO-026LC-F(E) | Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (4E10-IgG1) | ELISA | Human antibody |
| MRO-040LC-F(E) | Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (M66.6) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC746 | A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-4063CQ | Human Anti-HIV-1 gp41 Recombinant Antibody (MRO-4063CQ) | FC | Human IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY129 | Human Anti-HIV-1 gp41 (clone A2) scFv-Fc Chimera | Neut, ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-XY41 | Human Anti-HIV-1 gp41 Vaccinal Antibody (VS-0625-XY41) | ELISA | Human IgG |
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