Anti-HIV-1 gp41 Recombinant Antibody (M66.6) (CAT#: MRO-040LC)
This product is a recombinant human anti-HIV-1 monoclonal antibody. M66.6 specifically binds to gp41 membrane-proximal external region and can be potentially used in the treatment of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
Specific Inquiry
Neut
Figure 1. Residues of the m66.6 CDR L1 were swapped into the CDR L1 of m66 as listed, and the resulting variants tested for HIV-1 neutralization.
Ofek, G., Zirkle, B., Yang, Y., Zhu, Z., McKee, K., Zhang, B., ... & Mascola, J. R. (2014). Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66. 6. Journal of virology, 88(5), 2426-2441.
ELISA
Figure 2. Similar binding of m66.6 and 2F5 to the membrane-proximal external region (MPER) peptide SP62 and gp140-JRFL as measured by ELISA.
Zhu, Z., Qin, H. R., Chen, W., Zhao, Q., Shen, X., Schutte, R., ... & Fouda, G. G. (2011). Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of virology, 85(21), 11401-11408.
ELISA
Figure 1 Competition assay of 3A5a scFv and 2F5 IgG for binding to SP62 peptide.
Li, D., Liu, J., Zhang, L., Xu, T., Chen, J., Wang, L., & Zhao, Q. (2015). N-terminal residues of an HIV-1 gp41 membrane-proximal external region antigen influence broadly neutralizing 2F5-like antibodies. Virologica Sinica, 30(6), 449-456.
Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human antibody
- Specificity
- HIV-1
- Clone
- M66.6
- Applications
- ELISA
- Related Disease
- AIDS
Applications
- Application Notes
- The HIV-1 gp41 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP41; gp41; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
ScFv Antibody Products
Human Antibody Products
MHC Tetramer Products for Virology
IgM Antibody Products
IgG Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-185 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8062); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-186 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5); Fab Fragment | WB, Neut, FuncS | Human Fab |
| PFBL-187 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC176); Fab Fragment | Neut, FuncS | Human Fab |
| PFBL-188 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC315); Fab Fragment | Neut, FuncS | Human Fab |
| PFBL-189 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone m66); Fab Fragment | Neut, FuncS | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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