Anti-HIV-1 gp41 Recombinant Antibody (M66.6)
CAT#: MRO-040LC
This product is a recombinant human anti-HIV-1 monoclonal antibody. M66.6 specifically binds to gp41 membrane-proximal external region and can be potentially used in the treatment of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
Published Data
Neut
Figure 1. Residues of the m66.6 CDR L1 were swapped into the CDR L1 of m66 as listed, and the resulting variants tested for HIV-1 neutralization.
Ofek, G., Zirkle, B., Yang, Y., Zhu, Z., McKee, K., Zhang, B., ... & Mascola, J. R. (2014). Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66. 6. Journal of virology, 88(5), 2426-2441.
ELISA
Figure 2. Similar binding of m66.6 and 2F5 to the membrane-proximal external region (MPER) peptide SP62 and gp140-JRFL as measured by ELISA.
Zhu, Z., Qin, H. R., Chen, W., Zhao, Q., Shen, X., Schutte, R., ... & Fouda, G. G. (2011). Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of virology, 85(21), 11401-11408.
ELISA
Figure 1 Competition assay of 3A5a scFv and 2F5 IgG for binding to SP62 peptide.
Li, D., Liu, J., Zhang, L., Xu, T., Chen, J., Wang, L., & Zhao, Q. (2015). N-terminal residues of an HIV-1 gp41 membrane-proximal external region antigen influence broadly neutralizing 2F5-like antibodies. Virologica Sinica, 30(6), 449-456.
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Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human antibody
- Specificity
- HIV-1
- Clone
- M66.6
- Applications
- ELISA
- Related Disease
- AIDS
Applications
- Application Notes
- The HIV-1 gp41 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone M66.6"
- CAT
- Product Name
See other products for "HIV-1 gp41"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-185 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8062) | WB, ELISA, FuncS | Human IgG |
| PABL-186 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5) | WB, Neut, FuncS | Human IgG |
| PABL-187 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC176) | Neut, FuncS | Human IgG |
| PABL-188 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC315) | Neut, FuncS | Human IgG |
| PABL-189 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone m66) | Neut, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-185 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8062); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-186 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5); Fab Fragment | WB, Neut, FuncS | Human Fab |
| PFBL-187 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC176); Fab Fragment | Neut, FuncS | Human Fab |
| PFBL-188 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC315); Fab Fragment | Neut, FuncS | Human Fab |
| PFBL-189 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone m66); Fab Fragment | Neut, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-555 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8066); scFv Fragment | Neut | Human scFv |
| PSBL-556 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 11f10); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| PSBL-557 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 6a7); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| PSBL-558 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone mAb1281); scFv Fragment | ELISA, Neut | Human scFv |
| PSBL-559 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone NC-1); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-074LC | Anti-HIV-1 gp41 Recombinant Antibody (W) | ELISA | Human antibody |
| MRO-093LC | Anti-HIV-1 gp41 Recombinant Antibody (clone 43) | ELISA | Human antibody |
| MRO-025LC-F(E) | Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (4E10-IgG3) | ELISA | Human antibody |
| MRO-026LC-F(E) | Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (4E10-IgG1) | ELISA | Human antibody |
| MRO-040LC-F(E) | Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (M66.6) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC746 | A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-4063CQ | Human Anti-HIV-1 gp41 Recombinant Antibody (MRO-4063CQ) | FC | Human IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY129 | Human Anti-HIV-1 gp41 (clone A2) scFv-Fc Chimera | Neut, ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-XY41 | Human Anti-HIV-1 gp41 Vaccinal Antibody (VS-0625-XY41) | ELISA | Human IgG |
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