Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG1) (CAT#: MRO-026LC)
This product is a recombinant human anti-HIV-1 monoclonal antibody. 4E10-IgG1 specifically binds to gp41 and can be potentially used in the treatment of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Neut
Figure 1. Inhibition of HIV-1 infection in primary macrophages. All three MAbs were IgG; 4E10 served as a positive control, and the nonneutralizing anti-HIV-1 Mab A32 was used as a negative control.
Zhu, Z., Qin, H. R., Chen, W., Zhao, Q., Shen, X., Schutte, R., ... & Fouda, G. G. (2011). Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of virology, 85(21), 11401-11408.
ELISA
Figure 2. Antibody-dependent cell-mediated viral inhibition (ADCVI) of 2F5 and 4E10 in comparison to b12. Supernatant was collected and assayed for p27 by ELISA to measure viral inhibition.
Hessell, A. J., Rakasz, E. G., Tehrani, D. M., Huber, M., Weisgrau, K. L., Landucci, G., ... & Burton, D. R. (2010). Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. Journal of virology, 84(3), 1302-1313.
ELISA
Figure 1 Inhibition of binding of mAb 4E10 to ELISA plates pre-coated with (A) gp41 or (B) peptide 2031 after pre-incubation of mAb 4E10 with either gp41 or peptide 2031.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- HIV-1
- Clone
- 4E10-IgG1
- Applications
- ELISA
- Related Disease
- AIDS
Applications
- Application Notes
- The HIV-1 gp41 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP41; gp41; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-486-S(P) | Recombinant Human Anti-HIV-1 gp41 Antibody scFv Fragment | IF, Neut, FuncS | scFv |
| PSBL-185 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8062); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBL-186 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5); scFv Fragment | WB, Neut, FuncS | Human scFv |
| PSBL-187 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC176); scFv Fragment | Neut, FuncS | Human scFv |
| PSBL-188 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC315); scFv Fragment | Neut, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
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