Recombinant Human Antibody (8066) is capable of binding to HIV-1 gp41, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp41 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp41 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody is broadly neutralizing across a wide panel of B and C type HIV-1 viruses.
Figure 1 Western blot analysis under non-reducing conditions of gp41-derived constructs reacting with the monovalent Fab mF-8066.
(A) NCCG-gp41, N35CCG-N13, N34CCG, 6-HB and 5-helix. (B) Single and (C) double alanine scanning mutants of 6-HB involving solvent exposed N-HR residues that lie in the shallow groove between the two C-HR helices.
Gustchina, E., Louis, J. M., Frisch, C., Ylera, F., Lechner, A., Bewley, C. A., & Clore, G. M. (2009). Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naive human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth. Virology, 393(1), 112-119.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-486-S(P) | Recombinant Anti-HIV-1 gp41 Antibody scFv Fragment | FC, WB, FuncS | scFv |
MRO-4167CQ-S(P) | Monkey Anti-HIV-1 gp41 Recombinant Antibody (clone DH570); scFv Fragment | ELISA, Neut, FC | Monkey scFv |
MRO-4168CQ-S(P) | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 102-135); scFv Fragment | ELISA, WB | Mouse scFv |
PABJ-0150-S(P) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone N6 FR3-03); scFv Fragment | ELISA, Neut | Human scFv |
PABJ-0179-S(P) | Human Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PABJ-0179-S(P)) | ELISA, Neut, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-486 | Recombinant Human Anti-HIV-1 gp41 Antibody | ELISA, IP, FuncS | IgG |
MRO-842CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1911) | WB | Mouse IgG2a |
MRO-843CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 191) | WB | Mouse IgG2 |
MRO-844CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 10E9) | WB, RIPA, ELISA, IF | Mouse IgG1 |
MRO-845CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 10F6) | ELISA, WB, IP, IF | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-555 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8066); Fab Fragment | Neut | Human Fab |
PFBL-556 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 11f10); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
PFBL-557 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 6a7); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
PFBL-558 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone mAb1281); Fab Fragment | ELISA, Neut | Human Fab |
PFBL-559 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone NC-1); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-025LC | Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG3) | ELISA | Human antibody |
MRO-026LC | Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG1) | ELISA | Human antibody |
MRO-040LC | Anti-HIV-1 gp41 Recombinant Antibody (M66.6) | ELISA | Human antibody |
MRO-074LC | Anti-HIV-1 gp41 Recombinant Antibody (W) | ELISA | Human antibody |
MRO-077LC | Anti-HIV-1 gp41 Recombinant Antibody (3D6) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC746 | A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer | FCM |
There are currently no Customer reviews or questions for PABL-558. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.