Anti-Human LOXL2 Recombinant Antibody (Simtuzumab)
CAT#: TAB-890
Recombinant humanized antibody expressed in CHO binding to human LOXL2. Simtuzumab is a humanized monoclonal antibody designed for the treatment of fibrosis. It binds to LOXL2 and acts as an immunomodulator.













Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- undefined
- Derivation
- Humanized
- Type
- IgG4 - kappa
- Species Reactivity
- Human
- Applications
- Inhib, Agonist
- CAS
- 1318075-13-6
- Generic Name
- Simtuzumab
- MW
- 147.5 kDa
- Related Disease
- Myelofibrosis
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Applications
- Application Notes
- The LOXL2 ADCC antibody has been reported in applications of Inhibition, Agonist.
Inhib: 1, 10, and 50 μg/ml.
Agonist: 50 μg/ml.
Target
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-890, RRID: AB_3112015)
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Biosimilar Overview
Please refer to Simtuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Simtuzumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
See other products for "Simtuzumab"
Afuco™ Anti-LOXL2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-890)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human LOXL2. It is a humanized monoclonal antibody designed for the treatment of fibrosis. It binds to LOXL2 and acts as an immunomodulator.
DrugMonitor™ Anti-Simtuzumab Antibody (VS-1224-YC1091)Simtuzumab has been explored in trials for the treatment of myelofibrosis, pancreatic cancer, colorectal cancer, and idiopathic pulmonary fibrosis. The DrugMonitor™ Anti-Simtuzumab Antibody (VS-1224-YC1091) is an anti-drug antibody (ADA) against Simtuzumab. This drug-based antibody is raised in mice immunized with the Simtuzumab. The anti-Simtuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Simtuzumab in samples.
See other products for "LOXL2"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0412ZL | Rabbit anti-Human LOXL2 Antibody | ICC, IF, FACS, WB | |
HPAB-0163-LSX | Mouse Anti-LOXL2 Recombinant Antibody (HPAB-0163-LSX) | ELISA, WB, RIA | Mouse IgG |
MOB-015LC | Recombinant Mouse Anti-LOXL2 Recombinant Antibody (MOB-015LC) | ELISA, FuncS | Mouse IgG |
ZG-0447U | Rabbit Anti-LOXL2 Recombinant Antibody (clone 2E5) | ELISA, WB, IHC, IF, FC | Rabbit IgG |
VS3-FY856 | Recombinant Rabbit Anti-LOXL2 Antibody (clone R09-7J5) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0693CL | Mouse Anti-LOXL2 Recombinant Antibody (TAB-0693CL) | IF, ELISA, FC | Mouse IgG |
TAB-0693CL-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (TAB-0693CL-S(P)) | ELISA, FC | Mouse scFv |
TAB-0693CL-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (TAB-0693CL-F(E)) | ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2075 | Hi-Affi™ Recombinant Rabbit Anti-LOXL2 Monoclonal Antibody (DS2075AB) | ICC, IF, FC, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0160-LSX-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0160-LSX-S(P)) | ELISA | Mouse scFv |
HPAB-0161-LSX-S(P) | Human Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0161-LSX-S(P)) | ELISA, WB, RIA | Human scFv |
HPAB-0162-LSX-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0162-LSX-S(P)) | ELISA, WB, RIA | Mouse scFv |
HPAB-0163-LSX-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0163-LSX-S(P)) | ELISA, WB, RIA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0160-LSX-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0160-LSX-F(E)) | ELISA | Mouse Fab |
HPAB-0161-LSX-F(E) | Human Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0161-LSX-F(E)) | ELISA, WB, RIA | Human Fab |
HPAB-0162-LSX-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0162-LSX-F(E)) | ELISA, WB, RIA | Mouse Fab |
HPAB-0163-LSX-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0163-LSX-F(E)) | ELISA, WB, RIA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-890 | Afuco™ Anti-LOXL2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-890) | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0325-XY1256 | Anti-LOXL2 Immunohistochemistry Kit | IHC | |
VS-0525-XY4072 | Anti-Mouse LOXL2 Immunohistochemistry Kit | IHC | |
VS-0525-XY4071 | Anti-Human LOXL2 Immunohistochemistry Kit | IHC | |
VS-0525-XY4073 | Anti-Rat LOXL2 Immunohistochemistry Kit | IHC |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-FY144 | Human Anti-LOXL2 (clone Simtuzumab) scFv-Fc Chimera | Inhib | Human IgG4, scFv-Fc |
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