Anti-Human LOXL2 Recombinant Antibody (Simtuzumab) (CAT#: TAB-890)
Recombinant humanized antibody expressed in CHO binding to human LOXL2. Simtuzumab is a humanized monoclonal antibody designed for the treatment of fibrosis. It binds to LOXL2 and acts as an immunomodulator.
Specific Inquiry
Inhib
Figure 1 Effects of Simtuzumab on normal myofibroblast differentiation and invasion.
Fibroblast cultures derived from normal lung samples were treated with anti-LOXL2 (1, 10, and 50 μg/ml), BIBF1120 (300 nM) and their respective controls in the absence or presence of CpG (10 nM), IL-13 (10 ng/ml) or TGF-β (20 ng/ml).
Espindola, M. S., Habiel, D. M., Coelho, A. L., Mikels-Vigdal, A., & Hogaboam, C. M. (2019). Targeting Lysyl oxidase-like 2 in Idiopathic Pulmonary Fibrosis. bioRxiv, 813907.
Inhib
Figure 2 Effects of Simtuzumab on IPF myofibroblast differentiation and invasion.
Fibroblast cultures derived from IPF lung samples were treated with anti-LOXL2 (1, 10, and 50 μg/ml), BIBF1120 (300 nM) and their respective controls in the absence or presence of CpG (10 nM), IL-13 (10 ng/ml) or TGF-β (20 ng/ml).
Espindola, M. S., Habiel, D. M., Coelho, A. L., Mikels-Vigdal, A., & Hogaboam, C. M. (2019). Targeting Lysyl oxidase-like 2 in Idiopathic Pulmonary Fibrosis. bioRxiv, 813907.
Agonist
Figure 3 Simtuzumab accelerates cell differentiation in vitro.
Explanted lung cells from normal and IPF lung samples were treated with anti-LOXL2 (50 μg/ml), or IgG for 26 days. Media and treatments were replaced 2x/week until day 26.
Espindola, M. S., Habiel, D. M., Coelho, A. L., Mikels-Vigdal, A., & Hogaboam, C. M. (2019). Targeting Lysyl oxidase-like 2 in Idiopathic Pulmonary Fibrosis. bioRxiv, 813907.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- undefined
- Derivation
- Humanized
- Type
- IgG4 - kappa
- Species Reactivity
- Human
- Applications
- Inhib, Agonist
- CAS
- 1318075-13-6
- Generic Name
- Simtuzumab
- MW
- 147.5 kDa
- Related Disease
- Myelofibrosis
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Applications
- Application Notes
- The LOXL2 ADCC antibody has been reported in applications of Inhibition, Agonist.
Inhib: 1, 10, and 50 μg/ml.
Agonist: 50 μg/ml.
Target
- Alternative Names
- Simtuzumab;1318075-13-6;AB0024;GS-6624;LOXL2;lysyl oxidase-like 2;lysyl oxidase homolog 2;WS9 14;lysyl oxidase related 2;lysyl oxidase-like protein 2;lysyl oxidase-related protein 2;lysyl oxidase-related protein WS9-14;LOR2;WS9-14;
- Gene ID
- 4017
- UniProt ID
- Q9Y4K0
Related Resources
Please refer to Simtuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Simtuzumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Simtuzumab"
Afuco™ Anti-LOXL2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-890)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human LOXL2. It is a humanized monoclonal antibody designed for the treatment of fibrosis. It binds to LOXL2 and acts as an immunomodulator.
DrugMonitor™ Anti-Simtuzumab Antibody (VS-1224-YC1091)Simtuzumab has been explored in trials for the treatment of myelofibrosis, pancreatic cancer, colorectal cancer, and idiopathic pulmonary fibrosis. The DrugMonitor™ Anti-Simtuzumab Antibody (VS-1224-YC1091) is an anti-drug antibody (ADA) against Simtuzumab. This drug-based antibody is raised in mice immunized with the Simtuzumab. The anti-Simtuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Simtuzumab in samples.
See other products for "LOXL2"
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Mouse Antibody Products
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
Fab Antibody Products
IgG Antibody Products
ADCC Enhanced Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0693CL | Mouse Anti-LOXL2 Recombinant Antibody (TAB-0693CL) | IF, ELISA, FC | Mouse IgG |
| TAB-0693CL-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (TAB-0693CL-S(P)) | ELISA, FC | Mouse scFv |
| TAB-0693CL-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (TAB-0693CL-F(E)) | ELISA, FC | Mouse Fab |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-890, RRID: AB_3112015)
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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