Recombinant humanized antibody expressed in CHO binding to human LOXL2. Simtuzumab is a humanized monoclonal antibody designed for the treatment of fibrosis. It binds to LOXL2 and acts as an immunomodulator.
Figure 1 Effects of Simtuzumab on normal myofibroblast differentiation and invasion.
Fibroblast cultures derived from normal lung samples were treated with anti-LOXL2 (1, 10, and 50 μg/ml), BIBF1120 (300 nM) and their respective controls in the absence or presence of CpG (10 nM), IL-13 (10 ng/ml) or TGF-β (20 ng/ml).
Espindola, M. S., Habiel, D. M., Coelho, A. L., Mikels-Vigdal, A., & Hogaboam, C. M. (2019). Targeting Lysyl oxidase-like 2 in Idiopathic Pulmonary Fibrosis. bioRxiv, 813907.
Figure 2 Effects of Simtuzumab on IPF myofibroblast differentiation and invasion.
Fibroblast cultures derived from IPF lung samples were treated with anti-LOXL2 (1, 10, and 50 μg/ml), BIBF1120 (300 nM) and their respective controls in the absence or presence of CpG (10 nM), IL-13 (10 ng/ml) or TGF-β (20 ng/ml).
Espindola, M. S., Habiel, D. M., Coelho, A. L., Mikels-Vigdal, A., & Hogaboam, C. M. (2019). Targeting Lysyl oxidase-like 2 in Idiopathic Pulmonary Fibrosis. bioRxiv, 813907.
Figure 3 Simtuzumab accelerates cell differentiation in vitro.
Explanted lung cells from normal and IPF lung samples were treated with anti-LOXL2 (50 μg/ml), or IgG for 26 days. Media and treatments were replaced 2x/week until day 26.
Espindola, M. S., Habiel, D. M., Coelho, A. L., Mikels-Vigdal, A., & Hogaboam, C. M. (2019). Targeting Lysyl oxidase-like 2 in Idiopathic Pulmonary Fibrosis. bioRxiv, 813907.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-LOXL2 ADCC Recombinant Antibody (Simtuzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human LOXL2. Simtuzumab is a humanized monoclonal antibody designed for the treatment of fibrosis. It binds to LOXL2 and acts as an immunomodulator.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0412ZL | Rabbit anti-Human LOXL2 Antibody | ICC/IF, FACS, WB | |
HPAB-0160-LSX | Mouse Anti-LOXL2 Recombinant Antibody (HPAB-0160-LSX) | ELISA | Mouse IgG |
HPAB-0161-LSX | Human Anti-LOXL2 Recombinant Antibody (HPAB-0161-LSX) | ELISA, WB, RIA | Human IgG |
HPAB-0162-LSX | Mouse Anti-LOXL2 Recombinant Antibody (HPAB-0162-LSX) | ELISA, WB, RIA | Mouse IgG |
HPAB-0163-LSX | Mouse Anti-LOXL2 Recombinant Antibody (HPAB-0163-LSX) | ELISA, WB, RIA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0693CL | Mouse Anti-LOXL2 Recombinant Antibody (TAB-0693CL) | IF, ELISA, FC | Mouse IgG |
TAB-0693CL-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (TAB-0693CL-S(P)) | ELISA, FC | Mouse scFv |
TAB-0693CL-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (TAB-0693CL-F(E)) | ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2075 | Hi-Affi™ Recombinant Rabbit Anti-LOXL2 Monoclonal Antibody (DS2075AB) | ICC/IF, FC, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0160-LSX-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0160-LSX-S(P)) | ELISA | Mouse scFv |
HPAB-0161-LSX-S(P) | Human Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0161-LSX-S(P)) | ELISA, WB, RIA | Human scFv |
HPAB-0162-LSX-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0162-LSX-S(P)) | ELISA, WB, RIA | Mouse scFv |
HPAB-0163-LSX-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0163-LSX-S(P)) | ELISA, WB, RIA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0160-LSX-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0160-LSX-F(E)) | ELISA | Mouse Fab |
HPAB-0161-LSX-F(E) | Human Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0161-LSX-F(E)) | ELISA, WB, RIA | Human Fab |
HPAB-0162-LSX-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0162-LSX-F(E)) | ELISA, WB, RIA | Mouse Fab |
HPAB-0163-LSX-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0163-LSX-F(E)) | ELISA, WB, RIA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-890 | Afuco™ Anti-LOXL2 ADCC Recombinant Antibody (Simtuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
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