Afuco™ Anti-LOXL2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-890)
CAT#: AFC-TAB-890
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human LOXL2. It is a humanized monoclonal antibody designed for the treatment of fibrosis. It binds to LOXL2 and acts as an immunomodulator.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36257/847_B2_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56542/985_A11_1_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows moderate positivity in exocrine cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36257/752_B2_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_A_9_3.jpg
Normal Tissue
Figure 7 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_A_8_4.jpg
Normal Tissue
Figure 8 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_A_4_6.jpg
Normal Tissue
Figure 9 Placenta
Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25848/56663_A_3_7.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, TIME, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134013-LOXL2
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- FC, IP, ELISA, Neut, FuncS
- Conjugate
- Unconjugated
- Generic Name
- Simtuzumab
- Related Disease
- Myelofibrosis
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Biosimilar Overview
Please refer to Simtuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Simtuzumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Simtuzumab"
Anti-Human LOXL2 Recombinant Antibody (Simtuzumab)Recombinant humanized antibody expressed in CHO binding to human LOXL2. Simtuzumab is a humanized monoclonal antibody designed for the treatment of fibrosis. It binds to LOXL2 and acts as an immunomodulator.
DrugMonitor™ Anti-Simtuzumab Antibody (VS-1224-YC1091)Simtuzumab has been explored in trials for the treatment of myelofibrosis, pancreatic cancer, colorectal cancer, and idiopathic pulmonary fibrosis. The DrugMonitor™ Anti-Simtuzumab Antibody (VS-1224-YC1091) is an anti-drug antibody (ADA) against Simtuzumab. This drug-based antibody is raised in mice immunized with the Simtuzumab. The anti-Simtuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Simtuzumab in samples.
See other products for "LOXL2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-890 | Anti-Human LOXL2 Recombinant Antibody (Simtuzumab) | Inhib, Agonist | IgG4 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0693CL | Mouse Anti-LOXL2 Recombinant Antibody (TAB-0693CL) | IF, ELISA, FC | Mouse IgG |
| TAB-0693CL-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (TAB-0693CL-S(P)) | ELISA, FC | Mouse scFv |
| TAB-0693CL-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (TAB-0693CL-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2075 | Hi-Affi™ Recombinant Rabbit Anti-LOXL2 Monoclonal Antibody (DS2075AB) | ICC, IF, FC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0160-LSX | Mouse Anti-LOXL2 Recombinant Antibody (HPAB-0160-LSX) | ELISA | Mouse IgG |
| HPAB-0161-LSX | Human Anti-LOXL2 Recombinant Antibody (HPAB-0161-LSX) | ELISA, WB, RIA | Human IgG |
| HPAB-0162-LSX | Mouse Anti-LOXL2 Recombinant Antibody (HPAB-0162-LSX) | ELISA, WB, RIA | Mouse IgG |
| MRO-0937-CN | Recombinant Rabbit Anti-LOXL2 Monoclonal Antibody (JU32-53) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0447U | Rabbit Anti-LOXL2 Recombinant Antibody (clone 2E5) | ELISA, WB, IHC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0160-LSX-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0160-LSX-S(P)) | ELISA | Mouse scFv |
| HPAB-0161-LSX-S(P) | Human Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0161-LSX-S(P)) | ELISA, WB, RIA | Human scFv |
| HPAB-0162-LSX-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0162-LSX-S(P)) | ELISA, WB, RIA | Mouse scFv |
| HPAB-0163-LSX-S(P) | Mouse Anti-LOXL2 Recombinant Antibody; scFv Fragment (HPAB-0163-LSX-S(P)) | ELISA, WB, RIA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0160-LSX-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0160-LSX-F(E)) | ELISA | Mouse Fab |
| HPAB-0161-LSX-F(E) | Human Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0161-LSX-F(E)) | ELISA, WB, RIA | Human Fab |
| HPAB-0162-LSX-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0162-LSX-F(E)) | ELISA, WB, RIA | Mouse Fab |
| HPAB-0163-LSX-F(E) | Mouse Anti-LOXL2 Recombinant Antibody; Fab Fragment (HPAB-0163-LSX-F(E)) | ELISA, WB, RIA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1256 | Anti-LOXL2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4072 | Anti-Mouse LOXL2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4071 | Anti-Human LOXL2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4073 | Anti-Rat LOXL2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY144 | Human Anti-LOXL2 (clone Simtuzumab) scFv-Fc Chimera | Inhib | Human IgG4, scFv-Fc |
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