Recombinant Mouse Antibody (H5M9) is capable of binding to IAV HA, expressed in Chinese Hamster Ovary cells (CHO).
Figure 1 Neutralization activity of H5M9 to H5N1 viruses with wild-type VN1194 HA and its escape mutant D53N.
Neutralization activities were evaluated by plaque reduction neutralization assays using MDCK cells, which showed that D53N mutation confers resistance to H5M9.
Zhu, X., Guo, Y. H., Jiang, T., Wang, Y. D., Chan, K. H., Li, X. F.,... & Qin, C. F. (2013). A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin. Journal of virology, 87(23), 12619-12635.
Figure 2 Flow cytometry histograms of antibody H5M9 binding to wild-type or mutant VN1194 HA proteins from yeast surface display.
Zhu, X., Guo, Y. H., Jiang, T., Wang, Y. D., Chan, K. H., Li, X. F.,... & Qin, C. F. (2013). A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin. Journal of virology, 87(23), 12619-12635.
Figure 3 Prophylactic and therapeutic efficacy of H5M9 against lethal H5N1 infection in mice.
(A) Survival curves (left) and body weight loss (right) of BALB/c mice that received 2 or 20 mg/kg of H5M9 on 24 h before intranasal infection with 10 MLD 50 (50% mouse lethal doses) of VN1194 virus. (B) Survival curves (left) and body weight loss (right) of mice that received 2 or 20 mg/kg of H5M9 on 24 h postinfection with 10 MLD 50 of VN11904 virus.
Zhu, X., Guo, Y. H., Jiang, T., Wang, Y. D., Chan, K. H., Li, X. F.,... & Qin, C. F. (2013). A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin. Journal of virology, 87(23), 12619-12635.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-203 | Recombinant Human Anti-IAV HA Antibody (3.1) | WB, ELISA, FuncS | IgG |
PABL-204 | Recombinant Human Anti-IAV HA Antibody (39.29) | Neut, FuncS | IgG |
PABL-205 | Recombinant Human Anti-IAV HA Antibody (1957) | WB, Neut, FuncS | IgG |
PABL-206 | Recombinant Human Anti-IAV HA Antibody (1F1) | WB, ELISA, FuncS | IgG |
PABL-207 | Recombinant Human Anti-IAV HA Antibody (5J8) | FuncS | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-479 | Recombinant Human Anti-H1N1 HA Antibody Fab Fragment (CH65) | WB, ELISA, FuncS | Fab |
PFBL-480 | Recombinant Human Anti-H1N1 HA Antibody Fab Fragment (CH67) | Neut | Fab |
PFBL-481 | Recombinant Human Anti-H1N1 HA Antibody Fab Fragment (I2) | Neut | Fab |
PFBL-482 | Recombinant Mouse Anti-H1N1 HA Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
PFBL-484 | Recombinant Human Anti-H2N2 HA Antibody Fab Fragment (2G1 ) | Neut | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBC-233 | Recombinant Human Anti-H3N2 HA Antibody Fab Fragment (F045-092) | Neut | Fab |
HPAB-0929WJ-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (10F7) | ELISA | Mouse scFv |
HPAB-0930WJ-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (4D1) | ELISA | Mouse scFv |
HPAB-0931WJ-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (8H5) | ELISA | Mouse scFv |
HPAB-S0058-YC-S(P) | Mouse Anti-HA Recombinant Antibody (clone HC19); scFv Fragment | Neut | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-268CT | Anti-IAV HA Recombinant Antibody (D6-1) | WB, FC, IP | Human antibody |
MRO-269CT | Anti-IAV HA Recombinant Antibody (IgA 59) | WB, Neut | Human antibody |
MRO-270CT | Anti-IAV HA Recombinant Antibody (IgA 119) | WB, Neut | Human antibody |
MRO-271CT | Anti-IAV HA Recombinant Antibody (IgA 340) | WB, Neut | Human antibody |
MRO-272CT | Anti-IAV HA Recombinant Antibody (IgG 134) | WB, Neut | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-307CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (8982) | WB, ELISA | |
MRO-308CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (8153) | WB, ELISA | |
PABX-068-F (E) | Recombinant Mouse Anti-Hemagglutinin(HA) Antibody Fab Fragment (1F1) | WB, ELISA, FuncS | Fab |
PABX-069-F (E) | Recombinant Mouse Anti-Hemagglutinin(HA) Antibody Fab Fragment (S139/1 ) | ELISA, Neut, FuncS | Fab |
PABX-070-F (E) | Recombinant Mouse Anti-HA1 Antibody Fab Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-070-S (P) | Recombinant Mouse Anti-HA1 Antibody scFv Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4209 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI287DS) | ELISA, ICC/IF, IF, FC | IgG |
MOR-4210 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI288DS) | ELISA, ICC/IF, IF, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN0123 | APC-B*07:02/Influenza Hemagglutinin (IPSIQSRGL) MHC Tetramer | FCM | |
MHC-CN0124 | PE-B*07:02/Influenza Hemagglutinin (IPSIQSRGL) MHC Tetramer | FCM | |
MHC-YF182 | DRB1*01:01/Influenza HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF183 | DRB1*04:01/Influenza HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF1498 | BV421-DRB1*04:02/Human HA (PKYVKQNTLKLAT) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1169-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1169-FY) | Neut | Llama VHH |
HPAB-1170-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1170-FY) | Neut | Llama VHH |
HPAB-1171-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1171-FY) | Neut | Llama VHH |
HPAB-1172-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1172-FY) | Neut | Llama VHH |
HPAB-1173-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1173-FY) | Neut | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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