Recombinant Mouse Anti-IAV HA Antibody (H5M9) (CAT#: PABL-220)

Recombinant Mouse Antibody (H5M9) is capable of binding to IAV HA, expressed in Chinese Hamster Ovary cells (CHO).


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  • Published Data
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Figure 1 Neutralization activity of H5M9 to H5N1 viruses with wild-type VN1194 HA and its escape mutant D53N.

Figure 1 Neutralization activity of H5M9 to H5N1 viruses with wild-type VN1194 HA and its escape mutant D53N.

Neutralization activities were evaluated by plaque reduction neutralization assays using MDCK cells, which showed that D53N mutation confers resistance to H5M9.

Zhu, X., Guo, Y. H., Jiang, T., Wang, Y. D., Chan, K. H., Li, X. F.,... & Qin, C. F. (2013). A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin. Journal of virology, 87(23), 12619-12635.

Figure 2 Flow cytometry histograms of antibody H5M9 binding to wild-type or mutant VN1194 HA proteins from yeast surface display.

Figure 2 Flow cytometry histograms of antibody H5M9 binding to wild-type or mutant VN1194 HA proteins from yeast surface display.

Zhu, X., Guo, Y. H., Jiang, T., Wang, Y. D., Chan, K. H., Li, X. F.,... & Qin, C. F. (2013). A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin. Journal of virology, 87(23), 12619-12635.

Figure 3 Prophylactic and therapeutic efficacy of H5M9 against lethal H5N1 infection in mice.

Figure 3 Prophylactic and therapeutic efficacy of H5M9 against lethal H5N1 infection in mice.

(A) Survival curves (left) and body weight loss (right) of BALB/c mice that received 2 or 20 mg/kg of H5M9 on 24 h before intranasal infection with 10 MLD 50 (50% mouse lethal doses) of VN1194 virus. (B) Survival curves (left) and body weight loss (right) of mice that received 2 or 20 mg/kg of H5M9 on 24 h postinfection with 10 MLD 50 of VN11904 virus.

Zhu, X., Guo, Y. H., Jiang, T., Wang, Y. D., Chan, K. H., Li, X. F.,... & Qin, C. F. (2013). A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin. Journal of virology, 87(23), 12619-12635.


Specifications

  • Immunogen
  • Influenza a virus Hemagglutinin
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • IgG
  • Specificity
  • Tested positive against native IAV HA
  • Species Reactivity
  • IAV
  • Clone
  • H5M9
  • Applications
  • Neut, FC, WB, FuncS

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • The antibody was validated for Neutralization, Flow Cytometry and Function Assay. For details, refer to Published Data.

Target

  • Alternative Names
  • HA; hemagglutinin; haemagglutinin

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Human Antibody

Humanized Antibody

CAT Product Name Application Type
PABX-070-S (P) Recombinant Mouse Anti-HA1 Antibody scFv Fragment (Fab17/9) WB, ELISA, Neut, FuncS scFv

Rabbit Monoclonal Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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