Recombinant Human Antibody (MAb 3.1) is capable of binding to IAV HA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IAV HA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IAV HA mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody potently neutralizes influenza viruses from the H1a clade (i.e., H1, H2, H5, H6) but has little neutralizing activity against the H1b clade.
Figure 1 Figure 1 Neutralizing activity of monomeric 3.1 isotypes. mAb 3.1 IgA1 (red-bordered circles), IgA2 (red circles), IgG1 (black circles), and IgG3 (gray circles) against rg-A/Chicken/Vietnam/C58/2004 (H5N3). Both IgA subtypes neutralized more potently than the IgG subtypes.
Maurer, M. A., Meyer, L., Bianchi, M., Turner, H. L., Le, N. P., Steck, M.,... & Hangartner, L. (2018). Glycosylation of Human IgA Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses. Cell reports, 23(1), 90.
Figure 2 Figure 2 Neutralizing activity of IgG1/IgA1 chimeric 3.1 antibodies.
The four-letter code refers to the isotype origin of the CH1, hinge, CH2, and CH3, respectively. As a control, 3.1 was included as a pure IgG1 molecule (black closed circles) and an IgA1 molecule (black-bordered open circles) and plotted in each panel. The titration curves of the indicated chimeric molecules are depicted in gray-bordered open circles, while those for IgG1 and IgA1 are depicted in black and white circles, respectively. On top of each panel, the chimerism of the molecule is depicted with IgG1-derived areas in black, IgA1-derived areas in red, and the variable region in white.
Maurer, M. A., Meyer, L., Bianchi, M., Turner, H. L., Le, N. P., Steck, M.,... & Hangartner, L. (2018). Glycosylation of Human IgA Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses. Cell reports, 23(1), 90.
Figure 3 Figure 3 Antiviral Effect of Non-specific IgA.
Left panels: the antiviral activities of HIV-1 gp120- specific mAb b12 and H5-receptor binding sitespecific mAb 65c6 were tested against the indicated viruses. As a control, IgG1, IgA1 expressed in S cells (IgA1 S, red-bordered circles), and samples in which all IgA immunoglobulin has been depleted were used (red triangles). Right panels: antiviral activities of IgG1 or IgA1 of mAbs 3.1, 1.12, and HIV-gp41-specific mAb 2F5 were tested against Newcastle disease virus.
Maurer, M. A., Meyer, L., Bianchi, M., Turner, H. L., Le, N. P., Steck, M.,... & Hangartner, L. (2018). Glycosylation of Human IgA Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses. Cell reports, 23(1), 90.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-203 | Recombinant Human Anti-IAV HA Antibody (3.1) | WB, ELISA, FuncS | IgG |
PABL-204 | Recombinant Human Anti-IAV HA Antibody (39.29) | Neut, FuncS | IgG |
PABL-205 | Recombinant Human Anti-IAV HA Antibody (1957) | WB, Neut, FuncS | IgG |
PABL-206 | Recombinant Human Anti-IAV HA Antibody (1F1) | WB, ELISA, FuncS | IgG |
PABL-207 | Recombinant Human Anti-IAV HA Antibody (5J8) | FuncS | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-203 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (3.1) | WB, ELISA, FuncS | Fab |
PFBL-204 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (39.29) | Neut, FuncS | Fab |
PFBL-205 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1957) | WB, Neut, FuncS | Fab |
PFBL-206 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1F1) | WB, ELISA, FuncS | Fab |
PFBL-207 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (5J8) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-302CT | Anti-IAV HA Recombinant Antibody (Al7) | WB, ELISA, S-ELISA, IHC | |
MRO-303CT | Anti-IAV HA Recombinant Antibody (2242) | WB, ELISA | |
MRO-307CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (8982) | WB, ELISA | |
MRO-308CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (8153) | WB, ELISA | |
PABX-068-S (P) | Recombinant Mouse Anti-Hemagglutinin (HA) Antibody scFv Fragment (1F1) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-262CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (D3-4) | WB, FC, IP | Human antibody |
MRO-263CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (D4-2) | WB, FC, IP | Human antibody |
MRO-264CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (D4-3) | WB, FC, IP | Human antibody |
MRO-265CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (D4-4) | WB, FC, IP | Human antibody |
MRO-266CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (D4-5) | WB, FC, IP | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-070-S (P) | Recombinant Mouse Anti-HA1 Antibody scFv Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4209 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI287DS) | ELISA, ICC/IF, IF, FC | IgG |
MOR-4210 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI288DS) | ELISA, ICC/IF, IF, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1169-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1169-FY) | Neut | Llama VHH |
HPAB-1170-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1170-FY) | Neut | Llama VHH |
HPAB-1171-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1171-FY) | Neut | Llama VHH |
HPAB-1172-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1172-FY) | Neut | Llama VHH |
HPAB-1173-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1173-FY) | Neut | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0928WJ-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (3C8) | ELISA | Mouse scFv |
HPAB-0929WJ-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (10F7) | ELISA | Mouse scFv |
HPAB-0930WJ-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (4D1) | ELISA | Mouse scFv |
HPAB-0933WJ-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (2F2) | ELISA | Mouse scFv |
HPAB-S0058-YC-S(P) | Mouse Anti-HA Recombinant Antibody (clone HC19); scFv Fragment | Neut | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YF096 | DRB1*01:01/Influenza A HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF182 | DRB1*01:01/Influenza HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF183 | DRB1*04:01/Influenza HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF1498 | BV421-DRB1*04:02/Human HA (PKYVKQNTLKLAT) MHC Tetramer | FCM | |
MHC-YF1499 | BV421-DRB1*07:01/Human HA (PKYVKQNTLKLAT) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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