Herein provided is an agonist antibody to a human thrombopoietin receptor (human c-Mpl), and may be useful for treatment of thrombocytopenia.
Figure 1 shows binding activities of agonist antibodies.
Figure 2 represents activities of 7-10G4344uhm and 4-49G4344uhm as determined by UT7/TPO cell proliferation assay.
Figure 3 shows changes in platelet counts after administration of agonist antibodies to cynomolgus monkeys.
The agonist antibodies were administered to cynomolgus monkeys, and then platelet counts were monitored. Arrows indicate the dates of the first administration (PEG-rHuMGDF) and the second administration (agonist antibody).
Figure 4 shows daily changes in platelet counts after the administration of agonist antibodies to human Mpl Tg mice.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-155CQ | Human Anti-MPL Recombinant Antibody (TAB-155CQ) | ELISA, FC, FuncS | Human IgG1 |
TAB-155CQ-S(P) | Human Anti-MPL Recombinant Antibody; scFv Fragment (TAB-155CQ-S(P)) | ELISA, FC, WB | Human scFv |
TAB-155CQ-F(E) | Human Anti-MPL Recombinant Antibody; Fab Fragment (TAB-155CQ-F(E)) | ELISA, FC, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-156CQ | Anti-Human MPL Recombinant Antibody (TA136) | ELISA, FC | |
TAB-157CQ | Anti-Human MPL Recombinant Antibody (VB22B) | ELISA, FC | |
TAB-156CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (TA136) | ELISA, FC | |
TAB-157CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (VB22B) | ELISA, FC | |
TAB-156CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (TA136) | ELISA, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2272 | Hi-Affi™ Recombinant Rabbit Anti-MPL Monoclonal Antibody (DS2272AB) | FC, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-108LC | Recombinant Human Anti-Human MPL Agonist Antibody (12B5) | FC, FunS, ELISA | Human antibody |
MOB-109LC | Recombinant Human Anti-Human MPL Agonist Antibody (12D5) | FC, FunS, ELISA | Human antibody |
MOB-110LC | Recombinant Human Anti-Human MPL Agonist Antibody (12E10) | FC, FunS, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0566-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0566-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
HPAB-0567-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0567-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
HPAB-1580-FY-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-1580-FY-F(E)) | ELISA | Mouse Fab |
HPAB-1581-FY-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-1581-FY-F(E)) | ELISA | Mouse Fab |
HPAB-S0097-YC-S(P) | Human Anti-MPL Recombinant Antibody (clone 5E5); scFv Fragment | ELISA, Agonist | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0566-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0566-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
HPAB-0567-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0567-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
HPAB-0568-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0568-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
HPAB-0411-YC-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0411-YC-F(E)) | FC, ELISA | Mouse Fab |
HPAB-0412-YC-F(E) | Human Anti-MPL Recombinant Antibody (clone 7-10G4344uhm); Fab Fragment | FC, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0411-YC | Mouse Anti-MPL Recombinant Antibody (HPAB-0411-YC) | FC, ELISA | Mouse IgG1, κ |
HPAB-1580-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1580-FY) | WB, FC, ELISA | Mouse IgG |
HPAB-1581-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1581-FY) | FC | Mouse IgG |
HPAB-1582-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1582-FY) | ELISA | Mouse IgG |
VS3-XY1093 | Mouse Anti-MPL Recombinant Antibody (clone 1H2) | ELISA, WB, FC | Mouse IgG2b |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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