Recombinant Anti-MPL Vesicular Antibody, EV Displayed (VS-0425-YC552)
CAT#: VS-0425-YC552
The Recombinant Anti-MPL Vesicular Antibody, EV Displayed (VS-0425-YC552) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MPL-expressed cells or tissues. MPL relates to the thrombopoietin receptor, regulating megakaryocyte and platelet formation. It influences hematopoietic cell survival and is linked to TPO-R deficiencies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7619/1825_E1_28_cr5abb7d728bca3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (HEL)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117400-MPL
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Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MPL
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- MPL proto-oncogene, thrombopoietin receptor
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Nuclear membrane
- Introduction
- In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
- Alternative Names
- CD110, THPOR, TPOR
- Gene ID
- 4352
- UniProt ID
- P40238
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2377z | Mouse Anti-MPL Recombinant Antibody (clone 42A11) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| HPAB-0566-CN | Mouse Anti-MPL Recombinant Antibody (HPAB-0566-CN) | ELISA, FC, Block | Mouse IgG2b, κ |
| HPAB-0567-CN | Mouse Anti-MPL Recombinant Antibody (HPAB-0567-CN) | ELISA, FC, Block | Mouse IgG2b, κ |
| VS-0224-XY88 | Rat Anti-Mouse Mpl Recombinant Antibody (clone AMM2) | WB, FC, IP, Neut | Rat IgG1 |
| VS-0224-XY94 | Rabbit Anti-MPL Recombinant Antibody (VS-0224-XY94) | WB, IP, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-155CQ | Human Anti-MPL Recombinant Antibody (TAB-155CQ) | ELISA, FC, FuncS | Human IgG1 |
| TAB-155CQ-S(P) | Human Anti-MPL Recombinant Antibody; scFv Fragment (TAB-155CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-155CQ-F(E) | Human Anti-MPL Recombinant Antibody; Fab Fragment (TAB-155CQ-F(E)) | ELISA, FC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-156CQ | Anti-Human MPL Recombinant Antibody (TA136) | ELISA, FC | |
| TAB-156CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (TA136) | ELISA, FC | |
| TAB-157CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (VB22B) | ELISA, FC | |
| TAB-156CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (TA136) | ELISA, FC | |
| TAB-157CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (VB22B) | ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2272 | Hi-Affi™ Recombinant Rabbit Anti-MPL Monoclonal Antibody (DS2272AB) | FC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-108LC | Recombinant Human Anti-Human MPL Agonist Antibody (12B5) | FC, FunS, ELISA | Human antibody |
| MOB-109LC | Recombinant Human Anti-Human MPL Agonist Antibody (12D5) | FC, FunS, ELISA | Human antibody |
| MOB-110LC | Recombinant Human Anti-Human MPL Agonist Antibody (12E10) | FC, FunS, ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0566-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0566-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
| HPAB-0567-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0567-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
| HPAB-1580-FY-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-1580-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-1581-FY-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-1581-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-1582-FY-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-1582-FY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0566-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0566-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-0567-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0567-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-1580-FY-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-1580-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-1581-FY-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-1581-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-1582-FY-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-1582-FY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY143 | Human Anti-MPL (clone 5E5) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC127 | Recombinant Anti-MPL (Bin I x Bin II) Biparatopic Antibody, Tandem scFv | Block, ELISA, FC | Tandem scFv |
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