Recombinant Anti-MPL (Bin I x Bin II) Biparatopic Antibody, Tandem scFv
CAT#: VS-0525-YC127
The Recombinant Anti-MPL (Bin I x Bin II) Biparatopic Antibody, Tandem scFv is a biparatopic antibody (bpAb) engineered to bind two distinct epitopes of the MPL protein. The bpAb's tandem scFv arms enable simultaneous, high-affinity binding to both Bin I and Bin II of MPL.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7619/1825_E1_28_cr5abb7d728bca3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (HEL)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117400-MPL
❮
❯
Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Mouse
- Specificity
- Human MPL
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Epitope 1
- Bin I
- Epitope 2
- Bin II
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- Block, ELISA, FC
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- MPL Proto-Oncogene, Thrombopoietin Receptor
Target
- Introduction
- In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
- Alternative Names
- MPLV; TPOR; C-MPL; CD110; THCYT2
- Gene ID
- 4352
- UniProt ID
- P40238
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-155CQ | Human Anti-MPL Recombinant Antibody (TAB-155CQ) | ELISA, FC, FuncS | Human IgG1 |
| TAB-155CQ-S(P) | Human Anti-MPL Recombinant Antibody; scFv Fragment (TAB-155CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-155CQ-F(E) | Human Anti-MPL Recombinant Antibody; Fab Fragment (TAB-155CQ-F(E)) | ELISA, FC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-156CQ | Anti-Human MPL Recombinant Antibody (TA136) | ELISA, FC | |
| TAB-157CQ | Anti-Human MPL Recombinant Antibody (VB22B) | ELISA, FC | |
| TAB-156CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (TA136) | ELISA, FC | |
| TAB-156CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (TA136) | ELISA, FC | |
| TAB-157CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (VB22B) | ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2272 | Hi-Affi™ Recombinant Rabbit Anti-MPL Monoclonal Antibody (DS2272AB) | FC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-108LC | Recombinant Human Anti-Human MPL Agonist Antibody (12B5) | FC, FunS, ELISA | Human antibody |
| MOB-109LC | Recombinant Human Anti-Human MPL Agonist Antibody (12D5) | FC, FunS, ELISA | Human antibody |
| MOB-110LC | Recombinant Human Anti-Human MPL Agonist Antibody (12E10) | FC, FunS, ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0566-CN | Mouse Anti-MPL Recombinant Antibody (HPAB-0566-CN) | ELISA, FC, Block | Mouse IgG2b, κ |
| HPAB-0567-CN | Mouse Anti-MPL Recombinant Antibody (HPAB-0567-CN) | ELISA, FC, Block | Mouse IgG2b, κ |
| HPAB-0568-CN | Mouse Anti-MPL Recombinant Antibody (HPAB-0568-CN) | ELISA, FC, Block | Mouse IgG1, κ |
| HPAB-0411-YC | Mouse Anti-MPL Recombinant Antibody (HPAB-0411-YC) | FC, ELISA | Mouse IgG1, κ |
| HPAB-0412-YC | Human Anti-MPL Recombinant Antibody (HPAB-0412-YC) | FC, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0566-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0566-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
| HPAB-0567-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0567-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
| HPAB-0568-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0568-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
| HPAB-0411-YC-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0411-YC-S(P)) | FC, ELISA | Mouse scFv |
| HPAB-0412-YC-S(P) | Human Anti-MPL Recombinant Antibody scFv Fragment (HPAB-0412-YC-S(P)) | FC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0566-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0566-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-0567-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0567-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-0568-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0568-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-0411-YC-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0411-YC-F(E)) | FC, ELISA | Mouse Fab |
| HPAB-0412-YC-F(E) | Human Anti-MPL Recombinant Antibody Fab Fragment (HPAB-0412-YC-F(E)) | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY143 | Human Anti-MPL (clone 5E5) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC552 | Recombinant Anti-MPL Vesicular Antibody, EV Displayed (VS-0425-YC552) | Block, ELISA, FC, Cell-uptake |
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