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Human Anti-NRP1 Recombinant Antibody (CAT#: PABZ-095)

Recombinant Human Antibody is capable of binding to NRP1 b1b2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-NRP1 b1b2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-NRP1 b1b2 mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody inhibits VEGF165 binding to Nrp1.

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Normal Tissue
Figure 1 IHC staining of human duodenum
Figure 1 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows moderate granular positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/ihc_selected.jpg
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_B_9_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_3.jpg
Figure 4 Liver
Figure 4 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_7_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_8_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_6_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)
Figure 8 RNA cell line category: Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099250-NRP1

Specifications

  • Immunogen
  • Human neuropilin 1
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • Human IgG
  • Specificity
  • Tested positive against NRP1 b1b2
  • Species Reactivity
  • Human
  • Applications
  • Block

Product Property

  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Target

  • Alternative Names
  • NRP1; neuropilin 1; NP1; NRP; BDCA4; CD304; VEGF165R; neuropilin-1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT Product Name Application Type
MOB-1428z Mouse Anti-NRP1 Recombinant Antibody (clone 25G6) WB, ELISA, FC, ICC, IHC Mouse IgG1
MOR-2483 Hi-Affi™ Recombinant Rabbit Anti-NRP1 Monoclonal Antibody (DS2483AB) WB, FC, IP, IHC IgG
HPAB-1797-FY Human Anti-NRP1 Recombinant Antibody (HPAB-1797-FY) FC, ELISA Human IgG
VS3-CJ129 Rabbit Anti-NRP1 Recombinant Antibody (VS3-CJ129) WB, ELISA Rabbit IgG
VS3-XY1185 Mouse Anti-NRP1 Recombinant Antibody (clone 5D8) ELISA, WB, FC Mouse IgG1

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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