Anti-Human NRP1 Recombinant Antibody (Vesencumab)
CAT#: TAB-264
Recombinant monoclonal antibody to NRP1. Vesencumab is an immunomodulator designed for the treatment of solid malignancies. It binds to neuropilin 1.
Tested Data
Gene Expression
DB
Figure 1 Anti-Human NRP1 Therapeutic Antibody (TAB-264) in DB
Dot Blot analysis of TAB-264 was performed by coating with human NRP1 protein (His tag).
TAB-264 incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-Human IgG was used as a secondary antibody (1: 6000)
WB
Figure 2 Anti-Human NRP1 Therapeutic Antibody (TAB-264) in WB
Western blot analysis of TAB-264 was performed with human NRP1 protein onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-264 and HRP goat anti-Human IgG was used as a secondary antibody (1: 6000). Chemiluminescent detection was performed.
Lane 1: Reduced antigen (0.1 μg)
Lane 2: Reduced antigen (0.3 μg)
Lane 3: Reduced antigen (0.6 μg)
ELISA
Figure 3 Anti-Human NRP1 Therapeutic Antibody (TAB-264) in ELISA
ELISA analysis of TAB-264 was performed by coating with human NRP1 protein (His tag). Then blocked with BSA and incubated with TAB-264. The HRP-conjugated goat anti-Human IgG was used as a secondary antibody (1: 6000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
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Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows moderate granular positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099250-NRP1
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Suitable for use in WB, FuncS, IF, Neut, ELISA, FC, IP and most other immunological methods.
- CAS
- 1205533-60-3
- Generic Name
- Vesencumab
- MW
- 145.0 kDa
- Related Disease
- Solid tumors
Product Property
- Purity
- Purity >95% by SDS-PAGE.
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
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(Creative Biolabs Cat# TAB-264, RRID: AB_3111901)
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Vesencumab"
Afuco™ Anti-NRP1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-264)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to NRP1. It is an immunomodulator designed for the treatment of solid malignancies. It binds to neuropilin 1.
See other products for "NRP1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-589MZ-S(P) | Rabbit Anti-NRP1 Recombinant Antibody; scFv Fragment (TAB-589MZ-S(P)) | IHC | Rabbit scFv |
| TAB-590MZ-S(P) | Anti-Human NRP1 Recombinant Antibody scFv Fragment (1.004.012) | WB, IHC | |
| TAB-589MZ-F(E) | Rabbit Anti-NRP1 Recombinant Antibody; Fab Fragment (TAB-589MZ-F(E)) | IHC | Rabbit Fab |
| TAB-590MZ-F(E) | Anti-Human NRP1 Recombinant Antibody Fab Fragment (1.004.012) | WB, IHC | |
| TAB-591MZ-F(E) | Anti-Human NRP1 Recombinant Antibody Fab Fragment | FC, IP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1791CQ | Recombinant Rat Anti-Nrp1 Antibody (CBL881) | FC, Neut | IgG2 |
| NEUT-1793CQ | Recombinant Rat Anti-Nrp1 Antibody (CBL384) | CyTOF, FC, Neut | IgG2a |
| NEUT-1794CQ | Recombinant Mouse Anti-Nrp1 Antibody (CBL326) | BL, FC, CyTOF | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2501 | Hi-Affi™ Recombinant Rabbit Anti-NRP1 Monoclonal Antibody (DS2501AB) | WB, IHC-P, IP, FC, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0514-CN-S(P) | Human Anti-NRP1 Recombinant Antibody; scFv Fragment (HPAB-0514-CN-S(P)) | ELISA, FC, Block | Human scFv |
| NS-055CN-S(P) | Human Anti-NRP1 Recombinant Antibody; scFv Fragment (NS-055CN-S(P)) | ELISA, IP, IF | Human scFv |
| NS-056CN-S(P) | Human Anti-NRP1 Recombinant Antibody; scFv Fragment (NS-056CN-S(P)) | ELISA, IP, IF | Human scFv |
| NS-057CN-S(P) | Human Anti-NRP1 Recombinant Antibody; scFv Fragment (NS-057CN-S(P)) | ELISA, IP, IF | Human scFv |
| HPAB-1797-FY-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-1797-FY-F(E)) | FC, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-055CN | Human Anti-NRP1 Recombinant Antibody (NS-055CN) | ELISA, IP, IF, SPR | Human IgG |
| NS-056CN | Human Anti-NRP1 Recombinant Antibody (NS-056CN) | ELISA, IP, IF, SPR | Human IgG |
| NS-057CN | Human Anti-NRP1 Recombinant Antibody (NS-057CN) | ELISA, IP, IF, SPR | Human IgG |
| NS-055CN-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (NS-055CN-F(E)) | ELISA, IP, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-056CN-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (NS-056CN-F(E)) | ELISA, IP, IF | Human Fab |
| NS-057CN-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (NS-057CN-F(E)) | ELISA, IP, IF | Human Fab |
| HPAB-0717-FY-S(P) | Mouse Anti-NRP1 Recombinant Antibody (clone AB016); Fab Fragment | FC | Mouse Fab |
| HPAB-0721-FY-S(P) | Mouse Anti-NRP1 Recombinant Antibody (clone AB035); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1357-FY-S(P) | Human Anti-NRP1 Recombinant Antibody; scFv Fragment (HPAB-1357-FY-S(P)) | Block, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0370-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0370-YC) | ELISA, Inhib | Human IgG4 (S228P) |
| HPAB-N0371-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0371-YC) | ELISA, Inhib | Human IgG4 (S228P) |
| HPAB-N0372-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0372-YC) | ELISA, Inhib | Human IgG4 (S228P) |
| HPAB-N0373-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0373-YC) | ELISA, Inhib | Human IgG |
| HPAB-0717-FY | Mouse Anti-NRP1 Recombinant Antibody (clone AB016) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1080-CN | Recombinant Mouse Anti-NRP1 Monoclonal Antibody (A3-D1) | WB, IF, IHC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-264 | Afuco™ Anti-NRP1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-264) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1093 | PE-A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC | |
| MHC-CN1094 | APC-A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC | |
| MHC-CN1095 | FITC-A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC | |
| MHC-CN1096 | A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY206 | AbPlus™ Anti-NRP1 Magnetic Beads (VS-0424-XY206) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY87 | Human Anti-NRP1 (clone Vesencumab) scFv-Fc Chimera | IP, IF, FC, Neut, ELISA, ICC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC189 | Recombinant Anti-NRP1 Vesicular Antibody, EV Displayed (VS-0425-YC189) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4987 | Anti-NRP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4988 | Anti-Rat NRP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4989 | Anti-Human NRP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4990 | Anti-Mouse NRP1 Immunohistochemistry Kit | IHC |
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