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    NRP1

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    For Research Use Only. Not For Clinical Use.


    This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
    NRP1
    Protein class

    Cancer-related genes, CD markers, Plasma proteins, Transporters

    Predicted location

    Intracellular, Membrane, Secreted (different isoforms)

    Single cell type specificity

    Cell type enhanced (Adipocytes, Sertoli cells, Hepatic stellate cells, Endothelial cells)

    Immune cell specificity

    Immune cell enriched (plasmacytoid DC)

    Cell line specificity

    Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)

    Interaction

    Homodimer, and heterodimer with NRP2 (PubMed:17989695). Interacts with FER (By similarity). Interacts with PLXNB1 (PubMed:10520995). Interacts with VEGFA (PubMed:26503042, PubMed:19805273). Interacts with ABCB8/MITOSUR in mitochondria (PubMed:30623799). (Microbial infection) Interacts with SARS coronavirus-2/SARS-CoV-2 spike protein S1 (via the CendR motif RRAR).

    Molecular function

    Developmental protein, Heparin-binding, Receptor

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