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    Human Anti-NRP1 (clone Vesencumab) scFv-Fc Chimera (CAT#: VS-0325-FY87)

    The anti-NRP1 scFv-Fc antibody targets neuropilin-1 (NRP1), a receptor involved in angiogenesis, axon guidance, and cancer progression. It can modulate NRP1 signaling, potentially affecting vascular and tumor biology. The scFv-Fc format provides high specificity and prolonged half-life, enhancing its utility in research and therapeutic applications.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 IHC staining of human duodenum
    Figure 1 IHC staining of human duodenum
    (Immunohistochemical staining of human duodenum shows moderate granular positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/ihc_selected.jpg
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_B_9_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_7_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_8_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_6_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)
    Figure 8 RNA cell line category: Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099250-NRP1

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • Human NRP1
    • Species Reactivity
    • Human
    • Clone
    • Vesencumab
    • Applications
    • Immunoprecipitation, Immunofluorescence, Flow Cytometry, Neutralization, ELISA, ICC
    • Related Disease
    • Cancer and neurodegenerative disease

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Target

    • Alternative Names
    • Neuropilin 1; Vascular Endothelial Cell Growth Factor 165 Receptor; VEGF165R; NRP; Transmembrane Receptor; CD304 Antigen
    • Long Name
    • Neuropilin 1
    • Sequence Similarities
    • Belongs to the neuropilin family.
    • Cellular Localization
    • Mitochondrion membrane; Cell membrane; Cytoplasm
    • Post Translation Modifications
    • Glycosylation at Asn150, Asn261, Asn300, Asn522, Ser612, Thr827, Ser829, Thr830, Asn842, Ser844, and Asn892
      Ubiquitination at Lys53 and Lys106
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyConnect NRP1_HUMAN (1557)
      Glycosylation from GlyGen 16 sites, 54 N-linked glycans (4 sites), 5 O-linked glycans (8 sites)
    • Function
    • NRP1 (Neuropilin 1) is a co-receptor for VEGF and other signaling molecules, playing a crucial role in angiogenesis, axon guidance, and immune responses. It modulates various signaling pathways and is implicated in cancer progression and other diseases.

    Recommended Products

    Isotype Control

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "NRP1"

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    Human Antibody Products Fab Antibody Products Mouse Antibody Products Neutralizing Antibody Products Rabbit Monoclonal Antibody Products Neuroscience Antibody Products ScFv Antibody Products IgG Antibody Products IgM Antibody Products ADCC Enhanced Antibody Products MHC Tetramer Products for Cancer Antibody Magnetic Beads Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    TAB-264 Anti-Human NRP1 Recombinant Antibody (Vesencumab) IP, IF, FuncS, FC, Neut, ELISA, ICC IgG1 - kappa

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