Human Anti-NRP1 (clone Vesencumab) scFv-Fc Chimera

CAT#: VS-0325-FY87

The anti-NRP1 scFv-Fc antibody targets neuropilin-1 (NRP1), a receptor involved in angiogenesis, axon guidance, and cancer progression. It can modulate NRP1 signaling, potentially affecting vascular and tumor biology. The scFv-Fc format provides high specificity and prolonged half-life, enhancing its utility in research and therapeutic applications.

Gene Expression
Figure 1 IHC staining of human duodenum Figure 2 Cerebral cortex Figure 3 Colon Figure 4 Liver Figure 5 Kidney Figure 6 Testis Figure 7 Lymph node Figure 8 RNA cell line category: Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • Human NRP1
  • Species Reactivity
  • Human
  • Clone
  • Vesencumab
  • Applications
  • Immunoprecipitation, Immunofluorescence, Flow Cytometry, Neutralization, ELISA, ICC
  • Related Disease
  • Cancer and neurodegenerative disease

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Target

  • Alternative Names
  • Neuropilin 1; Vascular Endothelial Cell Growth Factor 165 Receptor; VEGF165R; NRP; Transmembrane Receptor; CD304 Antigen
  • Long Name
  • Neuropilin 1
  • Sequence Similarities
  • Belongs to the neuropilin family.
  • Cellular Localization
  • Mitochondrion membrane; Cell membrane; Cytoplasm
  • Post Translation Modifications
  • Glycosylation at Asn150, Asn261, Asn300, Asn522, Ser612, Thr827, Ser829, Thr830, Asn842, Ser844, and Asn892
    Ubiquitination at Lys53 and Lys106
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyConnect NRP1_HUMAN (1557)
    Glycosylation from GlyGen 16 sites, 54 N-linked glycans (4 sites), 5 O-linked glycans (8 sites)
  • Function
  • NRP1 (Neuropilin 1) is a co-receptor for VEGF and other signaling molecules, playing a crucial role in angiogenesis, axon guidance, and immune responses. It modulates various signaling pathways and is implicated in cancer progression and other diseases.
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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Isotype Control

Secondary Antibody

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