Anti-Nectin-4 (Enfortumab)-mc-val-cit-PABC-MMAE ADC (AGS-22ME) (CAT#: ADC-L004)
This ADC product is composed of an anti-Nectin-4 antibody (Enfortumab) conjuagated via a mc-val-cit-PABC linker to MMAE (Enfortumab-mc-val-cit-PABC-MMAE). It has demonstrated a response in solid tumor treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression

Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/1671_G1_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/1671_G1_2_selected.jpg

Figure 2 Skin 1
(High expression in skin 1)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_B_9_1_val_selected.jpg
(High expression in skin 1)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_B_9_1_val_selected.jpg

Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_9_3.jpg

Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_9_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_9_5.jpg

Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_6_6.jpg

Figure 6 Skin
(Epidermal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_B_5_8.jpg
(Epidermal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_B_5_8.jpg

Figure 7 RNA cell line category: Cell line enhanced (BEWO, HaCaT, MCF7, OE19, SK-BR-3, T-47d)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000143217-NECTIN4
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000143217-NECTIN4
Specifications
- Antibody Overview
- Fully human IgG1k monoclonal antibody that binds to Nectin-4
- Clone
- Enfortumab
- Antibody Conjugation
- Human
- Linker
- mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
- Alternative Names
- LNIR; PRR4; EDSS1; PVRL4; nectin-4
- Gene ID
- 81607
- UniProt ID
- Q96NY8
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Extracellular Vesicle (EV) Antibody Products
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H25 | Human Anti-NECTIN4 Recombinant Antibody (TAB-H25) | ELISA, Neut, IF, IP, FC, FuncS | Human IgG1, κ |
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