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Anti-Nectin-4 (Enfortumab)-mc-val-cit-PABC-MMAE ADC (AGS-22ME) (CAT#: ADC-L004)

This ADC product is composed of an anti-Nectin-4 antibody (Enfortumab) conjuagated via a mc-val-cit-PABC linker to MMAE (Enfortumab-mc-val-cit-PABC-MMAE). It has demonstrated a response in solid tumor treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/1671_G1_2_selected.jpg
Normal Tissue
Figure 2 Skin 1
Figure 2 Skin 1
(High expression in skin 1)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_B_9_1_val_selected.jpg
Figure 3 Colon
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_9_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_9_5.jpg
Figure 5 Testis
Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_6_6.jpg
Figure 6 Skin
Figure 6 Skin
(Epidermal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_B_5_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (BEWO, HaCaT, MCF7, OE19, SK-BR-3, T-47d)
Figure 7 RNA cell line category: Cell line enhanced (BEWO, HaCaT, MCF7, OE19, SK-BR-3, T-47d)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000143217-NECTIN4

Specifications

  • Antibody Overview
  • Fully human IgG1k monoclonal antibody that binds to Nectin-4
  • Clone
  • Enfortumab
  • Antibody Conjugation
  • Human
  • Linker
  • mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl)
  • Linker Class/Description
  • Class: Enzymatically cleavable linkers-Peptide linkers
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
  • Alternative Names
  • LNIR; PRR4; EDSS1; PVRL4; nectin-4

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Human Antibody

CAT Product Name Application Type
TAB-H25 Human Anti-NECTIN4 Recombinant Antibody (clone Enfortumab) ELISA, Neut, IF, IP, FC, FuncS Human IgG1, κ

Recombinant Antibody

CAT Product Name Application Type
HPAB-0034-DJB Mouse Anti-NECTIN4 Recombinant Antibody (clone N41) ELISA, IHC, FC Mouse IgG
VS4-CJ51 Recombinant Human Anti-NECTIN4 Antibody (clone 6D3) ELISA Human IgG1
VS-0723-WK124 Human Anti-NECTIN4 Recombinant Antibody (VS-0723-WK124) FC Chimeric (rabbit/human) IgG1

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0034-DJB-S(P) Mouse Anti-NECTIN4 Recombinant Antibody (clone N41); scFv Fragment ELISA, IHC, FC Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0034-DJB-F(E) Mouse Anti-NECTIN4 Recombinant Antibody (clone N41); Fab Fragment ELISA, IHC, FC Mouse Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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