Afuco™ Anti-Human PSCA ADCC Recombinant Antibody (AGS-1C4D4), ADCC Enhanced
CAT#: AFC-701CL
Anti-PSCA ADCC Enhanced Antibody (AGS-1C4D4) is an ADCC enhanced antibody produced by our Afuco™ platform. AGS-1C4D4 is a human monoclonal antibody against prostate stem cell antigen (PSCA), which is a cell-surface protein expressed by most prostate cancers. Preclinical studies demonstrated the pruduct has tumor inhibition function. A limited Phase I trial using AGS-1C4D4 was performed evaluating safety and PK.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
Normal Tissue
Figure 3 Stomach
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CAPAN-2, HeLa, OE19, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- FuncS
- Related Disease
- Prostate Cancer
Product Property
- Purity
- >95% as determined by analysis by RP-HPLC
- Storage
- Store at -20°C. Open under aseptic conditions.
Applications
- Application Notes
- The antibody was validated for Function Assay. For details, refer to Published Data.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-256CT | Anti-Human PSCA Recombinant Antibody (6B8) | IHC, FC | |
| TAB-257CT | Anti-Human PSCA Recombinant Antibody (1D7) | IHC, FC | |
| TAB-256CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (6B8) | IHC, FC | |
| TAB-257CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (1D7) | IHC, FC | |
| TAB-258CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (2B3) | IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-259CT | Anti-Human PSCA Recombinant Antibody (10C5) | IHC, FC | Human antibody |
| TAB-260CT | Anti-Human PSCA Recombinant Antibody (6E4) | IHC, FC | Human antibody |
| TAB-259CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (10C5) | IHC, FC | Human antibody |
| TAB-260CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (6E4) | IHC, FC | Human antibody |
| TAB-261CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (6D1) | IHC, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-262CT | Humanized Anti-PSCA Recombinant Antibody (TAB-262CT) | FuncS | Humanized antibody |
| TAB-262CT-S(P) | Humanized Anti-PSCA Recombinant Antibody; scFv Fragment (TAB-262CT-S(P)) | ELISA, FC | Humanized scFv |
| TAB-262CT-F(E) | Humanized Anti-PSCA Recombinant Antibody; Fab Fragment (TAB-262CT-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN | Mouse Anti-PSCA Recombinant Antibody (HPAB-0074-CN) | FC | Mouse IgG1, κ |
| HPAB-0286CQ | Human Anti-PSCA Recombinant Antibody (clone mAb 5F2) | FC, IHC, FuncS | Human IgG1 |
| HPAB-0287CQ | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11) | FC, IHC, Cyt, FuncS | Mouse IgG2b |
| HPAB-0288CQ | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8) | FC, IHC, FuncS | Mouse IgG2b |
| HPAB-1900-FY | Human Anti-PSCA Recombinant Antibody (HPAB-1900-FY) | FC, Inhib, WB, ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-S(P) | Mouse Anti-PSCA Recombinant Antibody; scFv Fragment (HPAB-0074-CN-S(P)) | FC | Mouse scFv |
| HPAB-0287CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-0288CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-1309WJ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone 6B8); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-1900-FY-F(E) | Human Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-1900-FY-F(E)) | FC, Inhib, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-F(E) | Mouse Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-0074-CN-F(E)) | FC | Mouse Fab |
| HPAB-0286CQ-F(E) | Human Anti-PSCA Recombinant Antibody (clone mAb 5F2); Fab Fragment | FC, IHC | Chimeric (mouse/human) Fab |
| HPAB-0287CQ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); Fab Fragment | FC, IHC | Mouse Fab |
| HPAB-1309WJ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone 6B8); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-1900-FY-S(P) | Human Anti-PSCA Recombinant Antibody; scFv Fragment (HPAB-1900-FY-S(P)) | FC, Inhib, WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY152 | Mouse Anti-PSCA (clone 6B8) scFv-Fc Chimera | ELISA, Cyt, FC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC192 | Recombinant Anti-PSCA Vesicular Antibody, EV Displayed (VS-0425-YC192) | ELISA, FC, Cell-uptake |
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