Afuco™ Anti-Human PSCA ADCC Recombinant Antibody (AGS-1C4D4), ADCC Enhanced (CAT#: AFC-701CL)

Anti-PSCA ADCC Enhanced Antibody (AGS-1C4D4) is an ADCC enhanced antibody produced by our Afuco™ platform. AGS-1C4D4 is a human monoclonal antibody against prostate stem cell antigen (PSCA), which is a cell-surface protein expressed by most prostate cancers. Preclinical studies demonstrated the pruduct has tumor inhibition function. A limited Phase I trial using AGS-1C4D4 was performed evaluating safety and PK.


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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Duration of (A) overall survival (OS) and (B) progression-free survival (PFS) by treatment arm. (A) OS. (B) PFS.

Figure 1 Duration of (A) overall survival (OS) and (B) progression-free survival (PFS) by treatment arm. (A) OS. (B) PFS.

Wolpin, B. M., O'reilly, E. M., Ko, Y. J., Blaszkowsky, L. S., Rarick, M., Rocha-Lima, C. M.,... & McWhirter, E. (2013). Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer. Annals of oncology,24(7), 1792-1801.

FuncS

Figure 2 Overall survival (OS) of patients receiving (A) gemcitabine and (B) gemcitabine versus gemcitabine plus AGS-1C4D4 by tumor PSCA staining.

Figure 2 Overall survival (OS) of patients receiving (A) gemcitabine and (B) gemcitabine versus gemcitabine plus AGS-1C4D4 by tumor PSCA staining.

(A) Gemcitabine arm only. (B) Gemcitabine arm and gemcitabine plus AGS-1C4D4 arm.

Wolpin, B. M., O'reilly, E. M., Ko, Y. J., Blaszkowsky, L. S., Rarick, M., Rocha-Lima, C. M.,... & McWhirter, E. (2013). Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer. Annals of oncology,24(7), 1792-1801.

Figure 3 Serum concentration-time curves after intravenous administration of AGS-1C4D4 at each dose level.

Figure 3 Serum concentration-time curves after intravenous administration of AGS-1C4D4 at each dose level.

Data are shown as means ± one standard error. The y-axis is in the log scale

Antonarakis, E. S., Carducci, M. A., Eisenberger, M. A., Denmeade, S. R., Slovin, S. F., Jelaca-Maxwell, K.,... & Morris, M. J. (2012). Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial. Cancer chemotherapy and pharmacology, 69(3), 763-771.

Figure 4 Waterfall plot showing best PSA response at any time compared to baseline.

Figure 4 Waterfall plot showing best PSA response at any time compared to baseline.

*24 mg/kg dose cohort, †48 mg/kg dose cohort

Antonarakis, E. S., Carducci, M. A., Eisenberger, M. A., Denmeade, S. R., Slovin, S. F., Jelaca-Maxwell, K.,... & Morris, M. J. (2012). Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial. Cancer chemotherapy and pharmacology, 69(3), 763-771.


Specifications

  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Applications
  • FuncS
  • Related Disease
  • Prostate Cancer

Product Property

  • Purity
  • >95% as determined by analysis by RP-HPLC
  • Storage
  • Store at -20°C. Open under aseptic conditions.

Applications

  • Application Notes
  • The antibody was validated for Function Assay. For details, refer to Published Data.

Target

  • Alternative Names
  • PSCA; prostate stem cell antigen; PRO232

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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