Human Anti-RSPO3 Recombinant Antibody Fab Fragment (HPAB-0037CQ-F(E))

Name: Human Anti-RSPO3 Recombinant Antibody Fab Fragment (HPAB-0037CQ-F(E))
SKU: HPAB-0037CQ-F(E)
Rating: 5 (1 reviews)

CAT#: HPAB-0037CQ-F(E)

Recombinant Humanized Fab fragment to RSPO3. The antibody has stronger inhibitors of β-catenin activity. This antibody blocks binding of RSPO3 to LGR5.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_A_7_3.jpg

Normal Tissue Figure 3 Kidney

Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_A_7_5.jpg

Normal Tissue Figure 4 Testis

Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_A_4_6.jpg

Normal Tissue Figure 5 Lymph node

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_A_9_8.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (A549, BJ hTERT+, hTERT-RPE1, U-138 MG, U-87 MG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000146374-RSPO3

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Specifications

Host Species
Human

Derivation
Humanized

Type
Humanized Fab

Specificity
Human RSPO3

Species Reactivity
Human

Applications
ELISA, Inhib

Related Disease
Non-small cell lung tumor

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
RSPO3; R-spondin 3; PWTSR; THSD2; CRISTIN1; R-spondin-3; R-spondin 3 homolog; roof plate-specific spondin-3; protein with TSP type-1 repeat; thrombospondin, type I, domain containing 2; thrombospondin type-1 domain-containing protein 2

Gene ID
84870

UniProt ID
Q9BXY4

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0037CQ-F(E).pdf

MSDS

MSDS - HPAB-0037CQ-F(E).pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application	Type
NAB-2146-VHH	Recombinant Anti-Human RSPO3 VHH Single Domain Antibody	IHC, IP, FC, Neut, FUNC	Llama VHH

CAT	Product Name	Application	Type
TAB-350CT	Mouse Anti-RSPO3 Recombinant Antibody (TAB-350CT)	WB, ELISA, Neut, FC, IHC, IP	Mouse IgG
TAB-353CT	Mouse Anti-RSPO3 Recombinant Antibody (TAB-353CT)	WB, ELISA, Neut, FC, IHC, IP	Mouse IgG
TAB-354CT	Mouse Anti-RSPO3 Recombinant Antibody (TAB-354CT)	WB, ELISA, Neut, FC, IHC, IP	Mouse IgG
TAB-355CT	Mouse Anti-RSPO3 Recombinant Antibody (TAB-355CT)	WB, ELISA, Neut, FC, IHC, IP	Mouse IgG
TAB-356CT	Mouse Anti-RSPO3 Recombinant Antibody (TAB-356CT)	WB, ELISA, Neut, FC, IHC, IP	Mouse IgG

CAT	Product Name	Application	Type
TAB-351CT	Humanized Anti-RSPO3 Recombinant Antibody (TAB-351CT)	WB, ELISA, Neut, FC, IHC, IP	Humanized IgG
TAB-351CT-S(P)	Humanized Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-351CT-S(P))	WB, ELISA, Neut, FC, IHC, IP	Humanized scFv
TAB-351CT-F(E)	Humanized Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-351CT-F(E))	WB, ELISA, Neut, FC, IHC, IP	Humanized Fab
TAB-449CQ	Anti-Human RSPO3 Recombinant Antibody (Rosmantuzumab)	ELISA, IHC, FC, IP, IF, FuncS	IgG1, κ

CAT	Product Name	Application	Type
HPAB-0036CQ-S(P)	Human Anti-RSPO3 Recombinant Antibody scFv Fragment (HPAB-0036CQ-S(P))	ELISA, Inhib	Humanized scFv
HPAB-0037CQ-S(P)	Human Anti-RSPO3 Recombinant Antibody scFv Fragment (HPAB-0037CQ-S(P))	ELISA, Inhib	Humanized scFv
HPAB-0038CQ-S(P)	Mouse Anti-RSPO3 Recombinant Antibody scFv Fragment (HPAB-0038CQ-S(P))	ELISA, Inhib	Mouse scFv
HPAB-M0618-YC-S(P)	Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); scFv Fragment	ELISA	Rat scFv
HPAB-0539-FY-S(P)	Mouse Anti-RSPO3 Recombinant Antibody; scFv Fragment (HPAB-0539-FY-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0036CQ-F(E)	Human Anti-RSPO3 Recombinant Antibody Fab Fragment (HPAB-0036CQ-F(E))	ELISA, Inhib	Humanized Fab
HPAB-0038CQ-F(E)	Mouse Anti-RSPO3 Recombinant Antibody Fab Fragment (HPAB-0038CQ-F(E))	ELISA, Inhib	Mouse Fab, κ
HPAB-M0618-YC-F(E)	Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); Fab Fragment	ELISA	Rat Fab
HPAB-M0619-YC-F(E)	Rat Anti-RSPO3 Recombinant Antibody (clone 11C10); Fab Fragment	ELISA	Rat Fab
HPAB-M0620-YC-F(E)	Rat Anti-RSPO3 Recombinant Antibody (clone 15F3); Fab Fragment	ELISA	Rat Fab

CAT	Product Name	Application	Type
HPAB-M0618-YC	Rat Anti-RSPO3 Recombinant Antibody (clone 4A6)	ELISA	Rat IgG2a
HPAB-M0619-YC	Rat Anti-RSPO3 Recombinant Antibody (clone 11C10)	ELISA	Rat IgG2
HPAB-M0620-YC	Rat Anti-RSPO3 Recombinant Antibody (clone 15F3)	ELISA	Rat IgG2
HPAB-M0621-YC	Human Anti-RSPO3 Recombinant Antibody (clone hu4A6.L4H2)	ELISA, FuncS	Human IgG1
HPAB-M0622-YC	Human Anti-RSPO3 Recombinant Antibody (clone hu11C10.L5H2)	ELISA, FuncS	Human IgG

CAT	Product Name	Application	Type
AFC-TAB-449CQ	Afuco™ Anti-RSPO3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-449CQ)	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0425-FY176	Human Anti-RSPO3 (clone Rosmantuzumab) scFv-Fc Chimera	ELISA, WB, FC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0525-XY6253	Anti-RSPO3 Immunohistochemistry Kit	IHC
VS-0525-XY6254	Anti-Mouse RSPO3 Immunohistochemistry Kit	IHC

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