Human Anti-RSPO3 (clone Rosmantuzumab) scFv-Fc Chimera (CAT#: VS-0425-FY176)

• Immunogen
• Human RSPO3 as an immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human RSPO3

• Species Reactivity
• Human

• Clone
• Rosmantuzumab

• Applications
• ELISA, Western Blot, Flow Cytometry

• Related Disease
• Fibrotic disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• R-Spondin 3; Thrombospondin Type-1 Domain-Containing Protein 2; Thrombospondin, Type I, Domain Containing 2; Protein With TSP Type-1 Repeat; Roof Plate-Specific Spondin-3; THSD2; PWTSR

• Gene ID
• 84870

• UniProt ID
• Q9BXY4

• Long Name
• R-Spondin 3

• Sequence Similarities
• Belongs to the R-spondin family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Asn36
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 4 sites

• Protein Refseq
• XP_016866867.1; XP_054212572.1; NP_116173.2

• Function
• Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis.
  Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.
  Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.
  Acts as a ligand for frizzled FZD8 and LRP6.
  May negatively regulate the TGF-beta pathway.
  Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells.
  Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3.

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