Rat Anti-RSPO3 Recombinant Antibody (clone 4A6) (CAT#: HPAB-M0618-YC)

Provided herein is an antibody that binds to human RSPO3, cyno RSPO3 and murine RSPO3 with a Kd of less than 0.5 nM. The antibody has a half-life of at least 6 days and reduce tumor growth.

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FuncS

Figure 1 Pharmacokinetic studies of the humanized antibodies hu4A6.L4H2, hu11C10.L5H2, hu15F3.L4H2, antibody 5D6, and control anti-gD in Balb/c nude mice following a single 5 mg/kg IV dose.

Mean serum concentrations of serum antibodies are shown over time. The 4A6, 15F3, and 11C10 antibodies demonstrated biphasic disposition profiles typical of IgG1 antibodies and were indistinguishable from the control anti-gD antibody.

FuncS

Figure 2 Pharmacokinetic studies of the humanized antibodies hu4A6.L4H2, hu11C10.L5H2, hu15F3.L4H2 following a single bolus dose of 10 mg/kg.


Specifications

  • Immunogen
  • Human RSPO3 protein
  • Host Species
  • Rat
  • Type
  • Rat IgG2a
  • Specificity
  • Human RSPO3
  • Species Reactivity
  • Human, Cynomolgus, Mouse
  • Clone
  • 4A6
  • Applications
  • ELISA

Applications

  • Application Notes
  • The antibody was validated for ELISA, Functional Assay. For details, refer to Published Data.

Target

  • Alternative Names
  • R-Spondin 3; Thrombospondin Type-1 Domain-Containing Protein 2; Thrombospondin, Type I, Domain Containing 2; Protein With TSP Type-1 Repeat; Roof Plate-Specific Spondin-3; THSD2; PWTSR;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

See other products for "RSPO3"


For research use only. Not intended for any clinical use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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