Anti-Human RSPO3 Recombinant Antibody (Rosmantuzumab) (CAT#: TAB-449CQ)
Recombinant monoclonal antibody to RSPO3. Rosmantuzumab is a humanized monoclonal antibody that can be potentially used in the treatment of Advanced Relapsed Tumor, Refractory Solid Tumors.
Specific Inquiry
Figure 1 CRC with PTPRK-RSPO3 fusions respond to RSPO3-taxane treatment.
(A) VACO6 cell line is responsive to irinotecan and nab-paclitaxel when combined with RSPO3 neutralizing antibody anti-Rspo3. (B) SNU1411 is non-responsive to anti-Rspo3, irinotecan, or anti-Rspo3 + irinotecan. SNU1411 can be sensitized to nab-paclitaxel when combined with anti-Rspo3. Anti-Rspo3 was dosed at 25 mpk Q2W on day 1, irinotecan was dosed at 10 mpk Q1W on days 3 and 10, and nab-paclitaxel was dosed at 25 mpk Q2W on day 3, 7–10 mice per treatment group. *p < 0.01 vs. nab-paclitaxel, **p < 0.001 vs. nab-paclitaxel, ns = not significant.
Fischer, M. M., Yeung, V. P., Cattaruzza, F., Hussein, R., Yen, W. C., Murriel, C., ... & Cain, J. (2017). RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations. Scientific reports, 7(1), 15270.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- IgG1, κ
- Specificity
- Human RSPO3
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- CAS
- 1684393-04-1
- Generic Name
- Rosmantuzumab
- UNII
- VD026R6TCI
- Related Disease
- Advanced Relapsed Tumor, Refractory Solid Tumors
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The RSPO3 antibody has been reported in applications of Neut.
Target
- Alternative Names
- RSPO3; R-spondin 3; PWTSR; THSD2; CRISTIN1; R-spondin-3; R-spondin 3 homolog; roof plate-specific spondin-3; protein with TSP type-1 repeat; thrombospondin, type I, domain containing 2; thrombospondin type-1 domain-containing protein 2
- Gene ID
- 84870
- UniProt ID
- Q9BXY4
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Rosmantuzumab"
Afuco™ Anti-RSPO3 ADCC Recombinant Antibody (Rosmantuzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to RSPO3. Rosmantuzumab is a humanized monoclonal antibody that can be potentially used in the treatment of Advanced Relapsed Tumor, Refractory Solid Tumors.
See other products for "RSPO3"
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Single Domain Antibody Products
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ADCC Enhanced Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2146-VHH | Recombinant Anti-Human RSPO3 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-449CQ, RRID: AB_3111950)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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