Anti-Human RSPO3 Recombinant Antibody (Rosmantuzumab)
CAT#: TAB-449CQ
Recombinant monoclonal antibody to RSPO3. Rosmantuzumab is a humanized monoclonal antibody that can be potentially used in the treatment of Advanced Relapsed Tumor, Refractory Solid Tumors.
Tested Data
Gene Expression
SDS-PAGE
Figure 1 Anti-Human RSPO3 Recombinant Antibody (TAB-449CQ) in SDS-PAGE
Lane 1: 2 μg, Non-Reducing mAb Lane 2: 2 μg, Reducing mAb
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Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_A_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29957/64165_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A549, BJ hTERT+, hTERT-RPE1, U-138 MG, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000146374-RSPO3
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- IgG1, κ
- Specificity
- Human RSPO3
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- CAS
- 1684393-04-1
- Generic Name
- Rosmantuzumab
- UNII
- VD026R6TCI
- Related Disease
- Advanced Relapsed Tumor, Refractory Solid Tumors
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The RSPO3 antibody has been reported in applications of Neut.
Target
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Highly Consistent Quality
In our research experiments, Rosmantuzumab has delivered highly consistent quality across various assay formats. The antibody's high purity and repeatability enable us to obtain reproducible results every time. We successfully used it in immunofluorescence and ELISA to track antigen expression, and its superior performance has contributed significantly to understanding cellular processes. The product's batch-to-batch consistency is outstanding, providing dependable support for our complex research projects.
Robust and Sensitive
Rosmantuzumab is a robust reagent with remarkable sensitivity that has transformed our experimental design. We used it extensively in ELISA and immunofluorescence studies to investigate protein expression patterns in cancer cell models, and it consistently provided clear and quantifiable signals. The high repeatability and specificity have helped us generate reliable data that advance our understanding of cellular interactions and matrix remodeling in the tumor microenvironment.
Q&As
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What is the main purpose of Rosmantuzumab?
A: Rosmantuzumab is a recombinant antibody developed for research purposes. It is designed to bind specifically to Human RSPO3 and is used to study expression patterns and signaling events in experimental models. As part of a high-quality recombinant portfolio, it exhibits high sensitivity, confirmed specificity, and excellent repeatability. Researchers employ this antibody in techniques such as immunoblotting, immunohistochemistry, ELISA, and immunofluorescence to elucidate underlying cellular mechanisms in disease models.
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What applications are recommended for using Rosmantuzumab in research?
A: Rosmantuzumab is versatile in research and can be used in multiple assay formats including immunohistochemistry (IHC), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). It is also suitable for IP analysis and quantitative receptor binding studies. These applications enable researchers to detect, quantify, and image its specific target in various experimental models, making it an invaluable tool for studying protein expression and cellular localization in systems such as cancer models and tissue remodeling studies.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-449CQ, RRID: AB_3111950)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Rosmantuzumab"
Afuco™ Anti-RSPO3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-449CQ)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to RSPO3. It is a humanized monoclonal antibody that can be potentially used in the treatment of Advanced Relapsed Tumor, Refractory Solid Tumors.
See other products for "RSPO3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2146-VHH | Recombinant Anti-Human RSPO3 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-351CT | Humanized Anti-RSPO3 Recombinant Antibody (TAB-351CT) | WB, ELISA, Neut, FC, IHC, IP | Humanized IgG |
| TAB-351CT-S(P) | Humanized Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-351CT-S(P)) | WB, ELISA, Neut, FC, IHC, IP | Humanized scFv |
| TAB-351CT-F(E) | Humanized Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-351CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-350CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-350CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
| TAB-353CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-353CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
| TAB-354CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-354CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
| TAB-355CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-355CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
| TAB-356CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-356CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0036CQ | Human Anti-RSPO3 Recombinant Antibody (HPAB-0036CQ) | ELISA, Inhib | Humanized IgG1, κ |
| HPAB-0037CQ | Human Anti-RSPO3 Recombinant Antibody (HPAB-0037CQ) | ELISA, Inhib, FC | Humanized IgG2, κ |
| HPAB-0038CQ | Mouse Anti-RSPO3 Recombinant Antibody (HPAB-0038CQ) | ELISA, Inhib | Mouse IgG2, κ |
| HPAB-M0618-YC | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6) | ELISA | Rat IgG2a |
| HPAB-M0619-YC | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10) | ELISA | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038CQ-F(E) | Mouse Anti-RSPO3 Recombinant Antibody Fab Fragment (HPAB-0038CQ-F(E)) | ELISA, Inhib | Mouse Fab, κ |
| HPAB-M0618-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); Fab Fragment | ELISA | Rat Fab |
| HPAB-M0619-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10); Fab Fragment | ELISA | Rat Fab |
| HPAB-M0620-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 15F3); Fab Fragment | ELISA | Rat Fab |
| HPAB-M0621-YC-F(E) | Human Anti-RSPO3 Recombinant Antibody (clone hu4A6.L4H2); Fab Fragment | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0618-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); scFv Fragment | ELISA | Rat scFv |
| HPAB-M0619-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10); scFv Fragment | ELISA | Rat scFv |
| HPAB-M0620-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 15F3); scFv Fragment | ELISA | Rat scFv |
| HPAB-M0621-YC-S(P) | Human Anti-RSPO3 Recombinant Antibody (clone hu4A6.L4H2); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-M0622-YC-S(P) | Human Anti-RSPO3 Recombinant Antibody (clone hu11C10.L5H2); scFv Fragment | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-449CQ | Afuco™ Anti-RSPO3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-449CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY176 | Human Anti-RSPO3 (clone Rosmantuzumab) scFv-Fc Chimera | ELISA, WB, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6253 | Anti-RSPO3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6254 | Anti-Mouse RSPO3 Immunohistochemistry Kit | IHC |
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