Afuco™ Anti-Human SHH ADCC Recombinant Antibody (MEDI-5304), ADCC Enhanced
CAT#: AFC-544CL
Anti-SHH ADCC Enhanced Antibody (MEDI-5304) is an ADCC enhanced antibody produced by our Afuco™ platform. MEDI-5304 is the first fully human hedgehog antibody which inhibited transcription of hedgehog target genes and osteoblast differentiation of C3H10T1/2 cells. MEDI-5304 represents a potent dual hedgehog inhibitor suitable for continued development to evaluate efficacy and safety in human patients with tumors harboring elevated levels of SHH or IHH.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (EFO-21, GAMG, OE19, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164690-SHH/subcellular
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Tumors
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- 4 °C, -20°C if preferred
Target
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Related Signaling Pathways
JAK-STAT Signaling Pathway
Related Diseases
Pancreatic Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-0710-CN-F(E) | Human Anti-SHH Recombinant Antibody (clone 3H8); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0711-CN-F(E) | Human Anti-SHH Recombinant Antibody (clone 6D7OP); Fab Fragment | ELISA, FC, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-902 | Recombinant Human Anti-human SHH Antibody | WB, IHC, FuncS | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-566CL | Anti-Human SHH Recombinant Antibody (MEDI-5304) | Inhib | Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-696 | Mouse Anti-SHH Recombinant Antibody (clone 5E1); scFv Fragment | Neut | Mouse scFv |
| HPAB-0710-CN-S(P) | Human Anti-SHH Recombinant Antibody (clone 3H8); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0711-CN-S(P) | Human Anti-SHH Recombinant Antibody (clone 6D7OP); scFv Fragment | ELISA, FC, Neut | Human scFv |
| HPAB-0712-CN-S(P) | Human Anti-SHH Recombinant Antibody (clone 3H8OP); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-N0236-YC-S(P) | Mouse Anti-SHH Recombinant Antibody; scFv Fragment (HPAB-N0236-YC-S(P)) | ELISA, FC, WB, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1955CQ | Recombinant Rat Anti-Shh Antibody (6K12) | IHC, Neut, WB | IgG2 |
| NEUT-1956CQ | Recombinant Rat Anti-Shh Antibody (CBL167) | IHC, Neut, WB | IgG2 |
| NEUT-1957CQ | Recombinant Rat Anti-Shh Antibody (CBL886) | Neut, WB | IgG2a |
| NEUT-1958CQ | Recombinant Mouse Anti-SHH Antibody (171018) | IHC-FoFr, WB, IHC-Fr, Neut, ELISA, ICC, IF | IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3261 | Hi-Affi™ Recombinant Rabbit Anti-SHH Monoclonal Antibody (DS3261AB) | FC, IHC-P, IP, WB | IgG |
| MOR-4739 | Hi-Affi™ Recombinant Rabbit Anti-SHH Monoclonal Antibody (TH253DS) | WB, IF, ICC, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-082CN | Human Anti-SHH Recombinant Antibody (clone 6D7) | ELISA, FC | Human IgG2 |
| NS-082CN-F(E) | Human Anti-SHH Recombinant Antibody (clone 6D7); Fab Fragment | ELISA, FC | Human Fab |
| NS-082CN-S(P) | Human Anti-SHH Recombinant Antibody (clone 6D7); scFv Fragment | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY476 | Mouse Anti-NHP SHH Recombinant Antibody (clone 5H4) | WB, IHC, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2063 | Anti-SHH Immunohistochemistry Kit | IHC | |
| VS-0525-XY6566 | Anti-Mouse SHH Immunohistochemistry Kit | IHC | |
| VS-0525-XY6567 | Anti-Monkey SHH Immunohistochemistry Kit | IHC |
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