Afuco™ Anti-Human SHH ADCC Recombinant Antibody (MEDI-5304), ADCC Enhanced
CAT#: AFC-544CL
Anti-SHH ADCC Enhanced Antibody (MEDI-5304) is an ADCC enhanced antibody produced by our Afuco™ platform. MEDI-5304 is the first fully human hedgehog antibody which inhibited transcription of hedgehog target genes and osteoblast differentiation of C3H10T1/2 cells. MEDI-5304 represents a potent dual hedgehog inhibitor suitable for continued development to evaluate efficacy and safety in human patients with tumors harboring elevated levels of SHH or IHH.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (EFO-21, GAMG, OE19, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164690-SHH/subcellular
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Tumors
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- 4 °C, -20°C if preferred
Target
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Related Signaling Pathways
JAK-STAT Signaling Pathway
Related Diseases
Pancreatic Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
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| HPAB-N0236-YC-S(P) | Mouse Anti-SHH Recombinant Antibody; scFv Fragment (HPAB-N0236-YC-S(P)) | ELISA, FC, WB, FuncS | Mouse scFv |
| HPAB-AP788-YC-S(P) | Human Anti-SHH Recombinant Antibody (clone 1A12); scFv Fragment | ELISA, Inhib | Human scFv |
| HPAB-AP789-YC-S(P) | Human Anti-SHH Recombinant Antibody (clone 1G12); scFv Fragment | ELISA, Inhib | Human scFv |
| HPAB-AP790-YC-S(P) | Human Anti-SHH Recombinant Antibody (clone 1H10); scFv Fragment | ELISA, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-566CL | Anti-Human SHH Recombinant Antibody (MEDI-5304) | Inhib | Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| NS-082CN | Human Anti-SHH Recombinant Antibody (clone 6D7) | ELISA, FC | Human IgG2 |
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| CAT | Product Name | Application | Type |
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| VS3-WK985 | Rabbit Anti-SHH Recombinant Antibody (VS3-WK985) | WB, ICC, IF, IHC, FC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP788-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 1A12); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-AP789-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 1G12); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-AP790-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 1H10); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-AP791-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 4B6); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-AP792-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 1G1); Fab Fragment | ELISA, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY476 | Mouse Anti-NHP SHH Recombinant Antibody (clone 5H4) | WB, IHC, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2063 | Anti-SHH Immunohistochemistry Kit | IHC | |
| VS-0525-XY6566 | Anti-Mouse SHH Immunohistochemistry Kit | IHC | |
| VS-0525-XY6567 | Anti-Monkey SHH Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC305 | SmartAb™ Recombinant Anti-SHH pH-dependent Antibody (VS-0825-YC305) | Inhibition | Human IgG |
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