Anti-Human SLC1A5 Recombinant Antibody (KM4018) (CAT#: TAB-1008CLV)
The anti-ASCT2 antibody KM4018 specifically binds system asc amino acid transporter 2, and can be used for treating the disease and disorders disease relating to system ASC amino acid transporter 2, such as cancer.
Specific Inquiry
FC
Figure 1 The reactivity of anti-ASCT2 monoclonal antibodies KM4000, KM4001, KM4008, KM4012 and KM4018 to human ASCT2-myc/His gene-introduced CHO cells (ASCT2/CHO), vector-introduced CHO cells (Vector/CHO) and KMS-11 by means of fluorescent cell staining (flow cytometer).
The abscissa represents an antibody concentration ( μg/ml), and the ordinate represents a mean fluorescence intensity. The mean fluorescence intensity is indicated by □ and solid line for KM511, by ■ and thick solid line for KM4000, by ▲ and dotted line for KM4001, by ◯ and dotted line for KM4008, by □ and dotted line for KM4012, by the symbol □ and solid line for rat IgG2a-UNLB, and by ▲ and thick solid line for KM4018.
Inhib
Figure 2 The inhibitory activities of anti-ASCT2 monoclonal antibodies KM4000, KM4001, KM4008, KM4012 and KM4018 on glutamine-dependent proliferation of the human colorectal cancer cell line WiDr.
The abscissa represents a final concentration ( μg/ml) of individual antibodies, and the ordinate represents a relative value (%) obtained by taking proliferation of non-antibody treated cells to be 100%. The relative proliferation rate is indicated by ♦ and solid line for KM4000, by ■ and solid line for KM4001, by Δ and solid line for KM4008, by ◯ and solid line for KM4012, by x and solid line for KM511, by ■ and solid line for KM4018, by × and solid line for rat IgG2a-UNLB, and by dotted line for AST mixture.
Inhib
Figure 3 The inhibitory activity of anti-ASCT2 human chimeric antibodies on glutamine-dependent proliferation of the human colorectal cancer cell line WiDr.
The abscissa represents a final concentration ( μg/ml) of individual antibodies, and the ordinate represents a relative value (%) obtained by taking proliferation of non-antibody treated cells to be 100%. The relative proliferation rate is indicated by ◯ and solid line for cKM4008, by ∆ and solid line for KM4012, by ■ and solid line for KM4018, by + and solid line for KM511 and by dotted line for AST mixture.
Specifications
- Immunogen
- Human ASCT2-myc/His (Extracellular Region of ASCT2)
- Host Species
- Mouse
- Specificity
- Human
- Clone
- KM4018
- Applications
- FC, Inhib
- Related Disease
- Cancer
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry and Inhibition.
Target
- Alternative Names
- SLC1A5; solute carrier family 1 (neutral amino acid transporter), member 5; R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1; neutral amino acid transporter B(0); ATB(0); RD114 virus receptor; baboon M7 virus receptor; neutral amino acid transporter B; solute carrier family 1 member 5; RD114/simian type D retrovirus receptor; sodium-dependent neutral amino acid transporter type 2
- Gene ID
- 6510
- UniProt ID
- Q15758
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1002CLV | Anti-Human SLC1A5 Recombinant Antibody (KM3842) | ELISA | |
| TAB-1003CLV | Anti-Human SLC1A5 Recombinant Antibody (KM3998) | FC, Inhib | |
| TAB-1004CLV | Anti-Human SLC1A5 Recombinant Antibody (KM4000) | FC, Inhib | |
| TAB-1005CLV | Anti-Human SLC1A5 Recombinant Antibody (KM4001) | FC, Inhib | |
| TAB-1006CLV | Anti-Human SLC1A5 Recombinant Antibody (KM4008) | FC, Inhib |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1009CLV | Anti-Human SLC1A5 Recombinant Antibody (cKM4008) | FC, ADCC, CDC, Inhib | Chimeric antibody (mouse/human) |
| TAB-1010CLV | Anti-Human SLC1A5 Recombinant Antibody (cKM4012) | FC, ADCC, CDC | Chimeric antibody (mouse/human) |
| TAB-1011CLV | Anti-Human SLC1A5 Recombinant Antibody (cKM4018) | FC, ADCC, CDC | Chimeric antibody (mouse/human) |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0245-YC | Human Anti-SLC1A5 Recombinant Antibody (HPAB-N0245-YC) | Cyt, FC, FuncS | Humanized IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0245-YC-S(P) | Human Anti-SLC1A5 Recombinant Antibody; scFv Fragment (HPAB-N0245-YC-S(P)) | Cyt, FC, FuncS | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0245-YC-F(E) | Human Anti-SLC1A5 Recombinant Antibody; Fab Fragment (HPAB-N0245-YC-F(E)) | Cyt, FC, FuncS | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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