Humanized Anti-TFRC Recombinant Antibody (TAB-611CT) (CAT#: TAB-611CT)
This product is a recombinant humanized antibody that specifically binds to human transferrin receptor (TfR) and primate TfR. The antibody was purified by affinity chromatography.
Specific Inquiry
ELISA
Figure 1 Anti-Human TfR Antibody (TAB-611CT) in ELISA
ELISA analysis of TAB-611CT was performed by coating with Cynomolgus Transferrin Receptor Protein and Human Transferrin Receptor Protein.
Red line: Recombinant Cynomolgus Transferrin Receptor Protein (His Tag)
Blue line: Recombinant Human Transferrin Receptor Protein (His Tag)
WB
Figure 2 Anti-Human TfR Antibody (TAB-611CT) in WB
Western blot analysis of TAB-611CT was performed with Recombinant Human Transferrin Receptor Protein.
Lane 1: Blank
Lane 2: Blank
Lane 3: 40ng Recombinant Cynomolgus Transferrin Receptor Protein
Lane 4: 40ng Recombinant Cynomolgus Transferrin Receptor Protein
Lane 5: Marker
Lane 6: 40ng Recombinant Human Transferrin Receptor Protein
Lane 7: 80ng Recombinant Human Transferrin Receptor Protein
Lane 8: 160ng Recombinant Human Transferrin Receptor Protein
Lane 9: 320ng Recombinant Human Transferrin Receptor Protein
Lane 10: Blank
Specifications
- Host Species
- Humanized
- Type
- Humanized IgG
- Specificity
- Human
- Species Reactivity
- Human, Cynomolgus monkey
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90; CD71); anti-CD71
- Gene ID
- 7037
- UniProt ID
- P02786
Related Resources
Desjardins, Cody A., et al. "Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice." Nucleic acids research 50.20 (2022): 11401-11414.
This study focuses on developing an enhanced delivery mechanism for phosphorodiamidate morpholino oligomers (PMO) to treat Duchenne muscular dystrophy (DMD). Traditional therapies aim to induce exon skipping in the dystrophin pre-mRNA to produce a functional dystrophin protein. However, these therapies often face challenges in effectively delivering PMO to cardiac and skeletal muscles. To address this, the researchers developed the FORCE™ platform, which utilizes a Fab fragment targeting the transferrin receptor 1 (TfR1) conjugated to the PMO. This approach demonstrated significantly improved muscle delivery, achieving dose-dependent and robust exon skipping and sustained dystrophin restoration in mdx mice, a model for DMD.
Creative Biolabs provided several key products for this study, significantly contributing to its success. They supplied the human monoclonal antibody targeting human TfR1 (15G11, Cat# TAB-611CT), which was essential for validating the specificity and efficacy of the FORCE™ conjugate. Additionally, Creative Biolabs provided other critical reagents and antibodies that facilitated the extensive biochemical and molecular analyses conducted in the study. These contributions were crucial in enabling the detailed examination of the FORCE™ platform's ability to enhance PMO delivery and restore dystrophin expression, thereby demonstrating its potential as an effective treatment approach for DMD.
More Infomation
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G067E | Anti-TFRC immunotoxin HB21 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G067D | Anti-TFRC immunotoxin HB21 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G067G | Anti-TFRC immunotoxin HB21 (scFv)-Gel | Cytotoxicity assay, Function study | |
| AGTO-G067R | Anti-TFRC immunotoxin HB21 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G067S | Anti-TFRC immunotoxin HB21 (scFv)-Sap | Cytotoxicity assay, Function study |
Customer Reviews and Q&As
Customer Review
Q&As
-
Great for TFRC Detection
The Anti-TFRC Recombinant Antibody has been excellent for our TFRC detection assays. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time. -
Effective in Immunoassays
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for TFRC is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab. -
Consistent and Reliable
This antibody has proven to be consistent and reliable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for TFRC have been particularly beneficial.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-611CT, RRID: AB_3111977)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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